PH30734A - Substituted pipecolinic acid derivatives as hiv protease inhibitors. - Google Patents

Substituted pipecolinic acid derivatives as hiv protease inhibitors.

Info

Publication number
PH30734A
PH30734A PH45862A PH45862A PH30734A PH 30734 A PH30734 A PH 30734A PH 45862 A PH45862 A PH 45862A PH 45862 A PH45862 A PH 45862A PH 30734 A PH30734 A PH 30734A
Authority
PH
Philippines
Prior art keywords
acid derivatives
protease inhibitors
hiv protease
pipecolinic acid
substituted
Prior art date
Application number
PH45862A
Other languages
English (en)
Inventor
Paul C Anderson
Soucy Francis
Yoakim Christiane
Lavallee Pierre
Pierre L Beaulieu
Original Assignee
Bio Mega Bohringer Ingelheim R
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Mega Bohringer Ingelheim R filed Critical Bio Mega Bohringer Ingelheim R
Publication of PH30734A publication Critical patent/PH30734A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PH45862A 1992-03-13 1993-03-11 Substituted pipecolinic acid derivatives as hiv protease inhibitors. PH30734A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85071692A 1992-03-13 1992-03-13

Publications (1)

Publication Number Publication Date
PH30734A true PH30734A (en) 1997-10-17

Family

ID=25308925

Family Applications (1)

Application Number Title Priority Date Filing Date
PH45862A PH30734A (en) 1992-03-13 1993-03-11 Substituted pipecolinic acid derivatives as hiv protease inhibitors.

Country Status (25)

Country Link
US (1) US5807870A (cs)
EP (1) EP0560268B1 (cs)
JP (1) JP3258422B2 (cs)
KR (1) KR950700253A (cs)
AP (1) AP393A (cs)
AT (1) ATE116640T1 (cs)
AU (1) AU670582B2 (cs)
CA (1) CA2131185C (cs)
CZ (1) CZ285589B6 (cs)
DE (1) DE69300043T2 (cs)
DK (1) DK0560268T3 (cs)
ES (1) ES2066623T3 (cs)
FI (1) FI944217A (cs)
GR (1) GR3015622T3 (cs)
HU (2) HUT70617A (cs)
IL (1) IL105035A (cs)
NO (1) NO302570B1 (cs)
NZ (1) NZ251267A (cs)
OA (1) OA10092A (cs)
PH (1) PH30734A (cs)
PL (1) PL176362B1 (cs)
RU (1) RU2140911C1 (cs)
SK (1) SK280161B6 (cs)
WO (1) WO1993018003A1 (cs)
ZA (1) ZA931776B (cs)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2130754C (en) 1992-03-11 2005-02-08 Damian W. Grobelny Amine derivatives of oxo- and hydroxy-substituted hydrocarbons
ATE253050T1 (de) 1992-03-11 2003-11-15 Narhex Ltd Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen
US6071895A (en) 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
US5888992A (en) 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
KR100336699B1 (ko) 1992-08-25 2002-05-13 윌리암스 로저 에이 레트로바이러스 프로테아제 저해제로서 유용한히드록시에틸아미노 술폰아미드
US5484926A (en) * 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
US5846993A (en) * 1992-12-22 1998-12-08 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
EP0610745A3 (en) * 1993-02-09 1994-09-28 Miles Inc Novel aminomethylene derivatives as immunosuppressants.
IL110898A0 (en) * 1993-09-10 1994-11-28 Narhex Australia Pty Ltd Polar-substituted hydrocarbons
US5527829A (en) * 1994-05-23 1996-06-18 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
CA2137406C (en) * 1994-12-06 2005-09-13 Pierre Louis Beaulieu Process for key intermediates for hiv protease inhibitors
US6037157A (en) 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
US5914332A (en) 1995-12-13 1999-06-22 Abbott Laboratories Retroviral protease inhibiting compounds
US5883252A (en) * 1996-01-26 1999-03-16 Vertex Pharmaceuticals Incorporated Aspartyl protease inhibitors
US5705647A (en) * 1996-09-05 1998-01-06 Agouron Pharmaceuticals, Inc. Intermediates for making HIV-protease inhibitors
US5925759A (en) 1996-09-05 1999-07-20 Agouron Pharmaceuticals, Inc. Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors
US5962725A (en) 1996-09-05 1999-10-05 Agouron Pharmaceuticals, Inc. Intermediate compounds useful for making HIV protease inhibitors such as nelfinavir
US6232333B1 (en) 1996-11-21 2001-05-15 Abbott Laboratories Pharmaceutical composition
US6001851A (en) * 1997-03-13 1999-12-14 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
US6084107A (en) * 1997-09-05 2000-07-04 Agouron Pharmaceuticals, Inc. Intermediates for making HIV-protease inhibitors
US6251906B1 (en) 1998-05-15 2001-06-26 Abbott Laboratories Retroviral protease inhibiting compounds
SI1248600T1 (sl) 2000-01-19 2008-08-31 Abbott Lab Izboljšane farmacevtske formulacije inhibitorjev proteaze HIV
US7119085B2 (en) 2000-03-23 2006-10-10 Elan Pharmaceuticals, Inc. Methods to treat alzheimer's disease
US6992081B2 (en) 2000-03-23 2006-01-31 Elan Pharmaceuticals, Inc. Compounds to treat Alzheimer's disease
US6846813B2 (en) * 2000-06-30 2005-01-25 Pharmacia & Upjohn Company Compounds to treat alzheimer's disease
US7034182B2 (en) * 2000-06-30 2006-04-25 Elan Pharmaceuticals, Inc. Compounds to treat Alzheimer's disease
US20030096864A1 (en) * 2000-06-30 2003-05-22 Fang Lawrence Y. Compounds to treat alzheimer's disease
EP1666452A2 (en) 2000-06-30 2006-06-07 Elan Pharmaceuticals, Inc. Compounds to treat Alzheimer's disease
PE20020276A1 (es) 2000-06-30 2002-04-06 Elan Pharm Inc COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
US6982264B2 (en) * 2001-06-27 2006-01-03 Elan Pharmaceuticals, Inc. Substituted alcohols useful in treatment of Alzheimer's disease
US20070213407A1 (en) * 2001-06-29 2007-09-13 Elan Pharmaceuticals And Pharmacia & Upjohn Company Llc Compounds to treat Alzheimer's disease
JP4482883B2 (ja) 2003-05-22 2010-06-16 リードケミカル株式会社 抗ウイルス作用を有する化合物およびその配合剤
BRPI0510746A (pt) 2004-06-10 2007-11-20 Univ Michigan State sìntese de caprolactama a partir de lisina
US8106090B2 (en) * 2005-07-20 2012-01-31 Eli Lilly And Company 1-amino linked compounds
BRPI0804506A2 (pt) * 2007-02-20 2011-08-30 Univ Michigan State processos para preparar caprolactama ou um derivado da mesma e ácido pipecolìnico, caprolactama ou um derivado da mesma, e, ácido pipecolìnico ou um derivado do mesmo
EP2131865B1 (en) 2007-03-12 2014-12-17 Nektar Therapeutics Oligomer-protease inhibitor conjugates
EP2262538B1 (en) 2008-03-12 2014-12-10 Nektar Therapeutics Oligomer-amino acid conjugate
JP2011529087A (ja) * 2008-07-24 2011-12-01 ドラス コーポレイション 環状アミドモノマーを作製する方法、ならびに関連する誘導体および方法
US20120108501A1 (en) 2009-06-12 2012-05-03 Nektar Therapeutics Protease Inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0264106B1 (en) * 1986-10-14 1994-03-16 Banyu Pharmaceutical Co., Ltd. 5-Substituted amino-4-hydroxy-pentanoic acid derivatives and their use
CA1340588C (en) * 1988-06-13 1999-06-08 Balraj Krishan Handa Amino acid derivatives
GB8927915D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Novel alcohols
GB8927913D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Amino acid derivatives
MY110227A (en) * 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
ZA931777B (en) * 1992-03-13 1993-09-23 Bio Mega Boehringer Ingelheim Substituted pyrrolidine derivatives as HIV protease inhibitors.
IL110255A (en) * 1993-07-16 1998-12-06 Merck & Co Inc Creation and resolution of 2 tert-butylcarboxamidopiprazine
US5480887A (en) * 1994-02-02 1996-01-02 Eli Lilly And Company Protease inhibitors
GB2292146A (en) * 1994-08-11 1996-02-14 Merck & Co Inc HIV protease inhibitors useful for the treatment of AIDS

Also Published As

Publication number Publication date
PL176362B1 (pl) 1999-05-31
HU9402613D0 (en) 1994-11-28
JPH0673004A (ja) 1994-03-15
EP0560268A1 (en) 1993-09-15
FI944217A0 (fi) 1994-09-13
GR3015622T3 (en) 1995-06-30
RU2140911C1 (ru) 1999-11-10
KR950700253A (ko) 1995-01-16
DE69300043T2 (de) 1995-05-24
SK280161B6 (sk) 1999-09-10
DE69300043D1 (de) 1995-02-16
WO1993018003A1 (en) 1993-09-16
NZ251267A (en) 1996-09-25
NO943383L (no) 1994-09-12
DK0560268T3 (da) 1995-06-12
EP0560268B1 (en) 1995-01-04
CA2131185A1 (en) 1993-09-16
IL105035A (en) 1997-07-13
CZ223294A3 (en) 1995-11-15
CZ285589B6 (cs) 1999-09-15
AP393A (en) 1995-08-07
RU94040841A (ru) 1996-07-20
JP3258422B2 (ja) 2002-02-18
HU211854A9 (en) 1995-12-28
AP9300495A0 (en) 1993-04-30
CA2131185C (en) 1997-05-27
IL105035A0 (en) 1993-07-08
ATE116640T1 (de) 1995-01-15
NO943383D0 (no) 1994-09-12
ES2066623T3 (es) 1995-03-01
ZA931776B (en) 1993-09-24
FI944217A (fi) 1994-09-13
HUT70617A (en) 1995-10-30
NO302570B1 (no) 1998-03-23
SK109094A3 (en) 1995-05-10
US5807870A (en) 1998-09-15
AU3880893A (en) 1993-10-05
AU670582B2 (en) 1996-07-25
OA10092A (en) 1996-12-18

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