PH30362A - Peptidic ketones as interleukin-1beta-converting enzyme inhibitors - Google Patents

Peptidic ketones as interleukin-1beta-converting enzyme inhibitors

Info

Publication number
PH30362A
PH30362A PH48226A PH48226A PH30362A PH 30362 A PH30362 A PH 30362A PH 48226 A PH48226 A PH 48226A PH 48226 A PH48226 A PH 48226A PH 30362 A PH30362 A PH 30362A
Authority
PH
Philippines
Prior art keywords
cr5r6
aryl
heteroaryl
compounds
interleukin
Prior art date
Application number
PH48226A
Other languages
English (en)
Inventor
Roland E Dolle
Todd L Graybill
Gary J Speier
Catherine P Prouty
Stanley J Schmidt
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of PH30362A publication Critical patent/PH30362A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PH48226A 1993-05-07 1994-05-06 Peptidic ketones as interleukin-1beta-converting enzyme inhibitors PH30362A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/060,197 US5462939A (en) 1993-05-07 1993-05-07 Peptidic ketones as interleukin-1β-converting enzyme inhibitors

Publications (1)

Publication Number Publication Date
PH30362A true PH30362A (en) 1997-04-02

Family

ID=22027975

Family Applications (1)

Application Number Title Priority Date Filing Date
PH48226A PH30362A (en) 1993-05-07 1994-05-06 Peptidic ketones as interleukin-1beta-converting enzyme inhibitors

Country Status (21)

Country Link
US (2) US5462939A (de)
EP (1) EP0623606B1 (de)
JP (1) JPH0725839A (de)
AT (1) ATE161849T1 (de)
AU (1) AU668465B2 (de)
CA (1) CA2123055A1 (de)
CZ (1) CZ108394A3 (de)
DE (1) DE69407654T2 (de)
DK (1) DK0623606T3 (de)
ES (1) ES2113606T3 (de)
FI (1) FI942107A (de)
GR (1) GR3026556T3 (de)
HK (1) HK1008146A1 (de)
HU (1) HU217070B (de)
IL (1) IL109585A0 (de)
NO (1) NO941675L (de)
NZ (1) NZ260477A (de)
PH (1) PH30362A (de)
RU (1) RU2133251C1 (de)
SK (1) SK282270B6 (de)
TW (1) TW377350B (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) * 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5874424A (en) * 1995-12-20 1999-02-23 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US6008217A (en) * 1995-12-20 1999-12-28 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US5462939A (en) * 1993-05-07 1995-10-31 Sterling Winthrop Inc. Peptidic ketones as interleukin-1β-converting enzyme inhibitors
US5843905A (en) * 1993-06-04 1998-12-01 Vertex Pharmaceuticals, Incorporated Peptidic phosphinyloxymethyl ketones as interleukin-1β-converting enzyme inhibitors
US5486623A (en) 1993-12-08 1996-01-23 Prototek, Inc. Cysteine protease inhibitors containing heterocyclic leaving groups
US5714484A (en) * 1993-12-08 1998-02-03 Prototek, Inc. α-(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors
US5798247A (en) * 1994-05-06 1998-08-25 Basf Aktiengesellschaft Organic-chemical compound with ice-inhibitory action
US5847135A (en) * 1994-06-17 1998-12-08 Vertex Pharmaceuticals, Incorporated Inhibitors of interleukin-1β converting enzyme
US5756466A (en) * 1994-06-17 1998-05-26 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US6420522B1 (en) * 1995-06-05 2002-07-16 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US5716929A (en) * 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US5585504A (en) * 1994-09-16 1996-12-17 Merck & Co., Inc. Process of making cox-2 inhibitors having a lactone bridge
WO1996029088A1 (en) * 1995-03-23 1996-09-26 Affymax Technologies N.V. Novel piperazine derivatives as type il-1 receptor antagonists
WO1996030395A2 (en) * 1995-03-31 1996-10-03 Takeda Chemical Industries, Ltd. Cysteine protease inhibitor
BR9608229A (pt) * 1995-05-09 1998-12-29 Bayer Ag Cetoenóis alquil-dihalogenofenil-substituídos
DE19534016A1 (de) * 1995-09-14 1997-03-20 Merck Patent Gmbh Biotinderivate
US5843904A (en) * 1995-12-20 1998-12-01 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1βconverting enzyme
US5869519A (en) * 1996-12-16 1999-02-09 Idun Pharmaceuticals, Inc. C-terminal modified (n-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US5968927A (en) * 1996-09-20 1999-10-19 Idun Pharmaceuticals, Inc. Tricyclic compounds for the inhibition of the ICE/ced-3 protease family of enzymes
US5877197A (en) * 1996-12-16 1999-03-02 Karanewsky; Donald S. C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US6184244B1 (en) 1996-12-16 2001-02-06 Idun Pharmaceuticals, Inc. C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
CA2306692C (en) * 1997-10-10 2010-09-21 Cytovia, Inc. Dipeptide apoptosis inhibitors and the use thereof
US6184210B1 (en) * 1997-10-10 2001-02-06 Cytovia, Inc. Dipeptide apoptosis inhibitors and the use thereof
WO1999046248A1 (en) 1998-03-09 1999-09-16 Vertex Pharmaceuticals Incorporated 1,2-diazepane derivatives as interleukin-1beta converting enzyme inhibitors
CA2323439A1 (en) * 1998-03-16 1999-09-23 Cytovia, Inc. Dipeptide caspase inhibitors and the use thereof
BR9909660A (pt) 1998-03-19 2000-11-21 Vertex Pharma Inibidores de caspases
US6242422B1 (en) 1998-10-22 2001-06-05 Idun Pharmacueticals, Inc. (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases
US7157430B2 (en) 1998-10-22 2007-01-02 Idun Pharmaceuticals, Inc. (Substituted)acyl dipeptidyl inhibitors of the ICE/CED-3 family of cysteine proteases
JP2002539183A (ja) * 1999-03-16 2002-11-19 サイトビア インコーポレイテッド 置換２−アミノベンズアミドカスパーゼインヒビターおよびその使用
ATE363465T1 (de) 1999-04-09 2007-06-15 Cytovia Inc Caspase inhibitoren und ihre verwendung
DE60040397D1 (de) 1999-08-27 2008-11-13 Cytovia Inc Substituierte alpha-hydroxy-säuren als caspase-hemmer und ihre verwendung
US6566338B1 (en) 1999-10-12 2003-05-20 Cytovia, Inc. Caspase inhibitors for the treatment and prevention of chemotherapy and radiation therapy induced cell death
US6525024B1 (en) 2000-04-17 2003-02-25 Idun Pharmaceuticals, Inc. Inhibitors of the ICE/ced-3 family of cysteine proteases
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
WO2002020465A2 (en) 2000-09-08 2002-03-14 Merck Frosst Canada & Co. Gamma-ketoacid dipeptides as inhibitors of caspase-3
AU2002314744A1 (en) * 2001-04-17 2002-10-28 Sepracor, Inc. Thiazole and other heterocyclic ligands and use thereof
DE10150203A1 (de) * 2001-10-12 2003-04-17 Probiodrug Ag Peptidylketone als Inhibitoren der DPIV
WO2003068242A1 (en) * 2002-02-11 2003-08-21 Vertex Pharmaceuticals Incorporated Phospholipids as caspase inhibitor prodrugs
EP1750689A1 (de) * 2004-05-15 2007-02-14 Vertex Pharmaceuticals Incorporated Behandlung von krampfanfällen mit ice-hemmern
US7531570B2 (en) * 2004-05-27 2009-05-12 Vertex Pharmaceuticals Incorporated Treatment of diseases using ICE inhibitors
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055451A (en) * 1986-12-22 1991-10-08 Syntex Inc. Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors
DE3737399A1 (de) * 1987-11-04 1989-05-18 Schwabe Willmar Gmbh & Co Aminosaeureester, verfahren zu ihrer herstellung und ihre verwendung
WO1991015577A1 (en) * 1990-04-04 1991-10-17 Black, Roy, A. INTERLEUKIN 1'beta' PROTEASE
DE69226820T2 (de) * 1991-06-21 1999-05-12 Merck & Co., Inc., Rahway, N.J. Peptidylderivate als Inhibitoren von Interleukin-1B-konvertierenden Enzymen
ATE257517T1 (de) * 1991-08-30 2004-01-15 Vertex Pharma Interleukin 1-beta protease und ihre inhibitoren
GB9123326D0 (en) * 1991-11-04 1991-12-18 Sandoz Ltd Improvements in or relating to organic compounds
EP0627926B1 (de) * 1992-02-21 1998-08-05 Merck & Co., Inc. (a New Jersey corp.) Peptidylderivate und inhibitoren des interleukin-1-g(b)-konvertierenden enzyms
US5462939A (en) * 1993-05-07 1995-10-31 Sterling Winthrop Inc. Peptidic ketones as interleukin-1β-converting enzyme inhibitors

Also Published As

Publication number Publication date
HK1008146A1 (en) 1999-04-30
RU2133251C1 (ru) 1999-07-20
GR3026556T3 (en) 1998-07-31
NO941675D0 (no) 1994-05-06
EP0623606A3 (de) 1994-12-07
HU217070B (hu) 1999-11-29
ATE161849T1 (de) 1998-01-15
SK282270B6 (sk) 2001-12-03
EP0623606A2 (de) 1994-11-09
DE69407654D1 (de) 1998-02-12
SK50994A3 (en) 1995-02-08
US5462939A (en) 1995-10-31
DE69407654T2 (de) 1999-01-21
US5585486A (en) 1996-12-17
CA2123055A1 (en) 1994-11-08
AU668465B2 (en) 1996-05-02
IL109585A0 (en) 1994-08-26
FI942107A (fi) 1994-11-08
DK0623606T3 (da) 1998-09-07
TW377350B (en) 1999-12-21
JPH0725839A (ja) 1995-01-27
EP0623606B1 (de) 1998-01-07
NZ260477A (en) 1995-12-21
FI942107A0 (fi) 1994-05-06
AU6190694A (en) 1994-11-10
HU9401423D0 (en) 1994-08-29
HUT68791A (en) 1995-07-28
ES2113606T3 (es) 1998-05-01
CZ108394A3 (en) 1994-12-15
NO941675L (no) 1994-11-08

Similar Documents

Publication Publication Date Title
PH30362A (en) Peptidic ketones as interleukin-1beta-converting enzyme inhibitors
RU94015842A (ru) Пептидные кетоны, фармацевтическая композиция и способ ингибирования интерлейкин-1 протеазы
FI942005A0 (fi) Peptidianalogeja irreversiibeleinä interleukiini-1beta-proteaasi-inhibiittoreina
NZ296479A (en) Amino acid or peptide derivatives which are inhibitors of multicatalytic protease (mcp)
NZ501346A (en) Valinyl aromatic beta amino acid dipeptide compounds having fungicidal activity and their agronomic use
GB2382346A (en) Method of synthesizing diketopiperazines
NZ336046A (en) Serine protease inhibitors containing substituted oxadiazole, thiadiazole and triazole peptide derivatives
KR910020031A (ko) 펩티드 아미드, 이의 제조방법 및 피브린/트롬빈 응괴 억제제로서 이를 함유하는 약제
DK0930883T3 (da) Neurotrofinantagonister til behandling af epilepsi, Alzheimers sygdom og smerte
NO924915D0 (no) Sakkarinderivater med inhiberende virkning paa protolytiske enzymer
NZ334906A (en) A sulphonamido pentanoic acid derivative useful as an interleukin-1-beta converting enzyme inhibitor
DE3784743D1 (en) Hydroxamsaeuren.
Dolle et al. Peptidic ketones as interleukin-1 beta-converting enzyme inhibitors
FR2669339B1 (fr) Nouveaux derives peptidiques, procede de preparation et application a titre de medicaments de ces nouveaux derives.
MX9700828A (es) Analogos del acido aspartico como inhibidores de la enzima que convierte a la interleucina-1 beta.
DK0955310T3 (da) Hidtil ukendte (3,4,7,8,9,10)-hexahydro-6,10-dioxo-6H-pyridazino[1,2-a][1,2]diazepin-1-carboxylsyrederivater, fremgangsmåde til fremstilling af disse og anvendelse af disse til fremstilling af lægemidler
DK680888D0 (da) Fremgangsmaade til fremstilling af dipeptider
DK1155138T3 (da) Fremgangsmåde til fremstilling af optisk aktive 3,3,3-trifluormethyl-2-alkylpropionsyrederivater
TH13640A (th) Hemoregulatory peptides เปปไทด์ที่ควบคุม
DK0912751T3 (da) Fremgangsmåde til fremstilling af D-prolinderivater ved hjælp mikroorganismer