NO941675L - Peptid-ketoner som inhibitorer av interleukin-1beta-omdannede enzym - Google Patents

Peptid-ketoner som inhibitorer av interleukin-1beta-omdannede enzym

Info

Publication number
NO941675L
NO941675L NO941675A NO941675A NO941675L NO 941675 L NO941675 L NO 941675L NO 941675 A NO941675 A NO 941675A NO 941675 A NO941675 A NO 941675A NO 941675 L NO941675 L NO 941675L
Authority
NO
Norway
Prior art keywords
cr5r6
aryl
heteroaryl
compounds
interleukin
Prior art date
Application number
NO941675A
Other languages
English (en)
Other versions
NO941675D0 (no
Inventor
Roland E Dolle
Todd L Graybill
Gary J Speir
Catherine P Prouty
Stanley J Schmidt
Original Assignee
Sterling Winthrop Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Winthrop Inc filed Critical Sterling Winthrop Inc
Publication of NO941675D0 publication Critical patent/NO941675D0/no
Publication of NO941675L publication Critical patent/NO941675L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Furan Compounds (AREA)

Abstract

Forbindelse med formel (I) og farmasøytiske akseptable salter derav: co. (D hvor R! er (CR5R6)n, (CR5R6)n-aryl, (CR5R6)n-heteroaryl, X-(CR5R6)n, X-(CR5R6)n-aryl eller X-(CR5R6)n- heteroaryl hvor aryl og heteroaryl kan eventult være sub- stituert; X er O eller NR5; R5 og Rf, er uavhengig H eller lavere alkyl; R2 er H, halo, lavere alkyl eller (CR5R(, )n-aryl; R3 og R4 er uavhengig H eller alkyl; A er en D eller L isomer av en aminosyre valgt fra gruppen bestående av alanin, valln, leucin, isoleucin, prolin, fenylalanin, glycin, tyrosin, methionin, asparagin, glutamin, asparaginsyre, glutamlnsyre, lysin, arginin, histldin og a- thienylalanln; Z er CH eller O og n er 0-4; farmasøytisk sammensetninger inneholdende for- bindelsene; og en fremgangsmåte for inhibering av interleukin-ie proteaseaktlviteten i et pattedyr som anvender forbindelsene og sammensetningene, er beskrevet.
NO941675A 1993-05-07 1994-05-06 Peptid-ketoner som inhibitorer av interleukin-1beta-omdannede enzym NO941675L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/060,197 US5462939A (en) 1993-05-07 1993-05-07 Peptidic ketones as interleukin-1β-converting enzyme inhibitors

Publications (2)

Publication Number Publication Date
NO941675D0 NO941675D0 (no) 1994-05-06
NO941675L true NO941675L (no) 1994-11-08

Family

ID=22027975

Family Applications (1)

Application Number Title Priority Date Filing Date
NO941675A NO941675L (no) 1993-05-07 1994-05-06 Peptid-ketoner som inhibitorer av interleukin-1beta-omdannede enzym

Country Status (21)

Country Link
US (2) US5462939A (no)
EP (1) EP0623606B1 (no)
JP (1) JPH0725839A (no)
AT (1) ATE161849T1 (no)
AU (1) AU668465B2 (no)
CA (1) CA2123055A1 (no)
CZ (1) CZ108394A3 (no)
DE (1) DE69407654T2 (no)
DK (1) DK0623606T3 (no)
ES (1) ES2113606T3 (no)
FI (1) FI942107A (no)
GR (1) GR3026556T3 (no)
HK (1) HK1008146A1 (no)
HU (1) HU217070B (no)
IL (1) IL109585A0 (no)
NO (1) NO941675L (no)
NZ (1) NZ260477A (no)
PH (1) PH30362A (no)
RU (1) RU2133251C1 (no)
SK (1) SK282270B6 (no)
TW (1) TW377350B (no)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) * 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5874424A (en) * 1995-12-20 1999-02-23 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US6008217A (en) * 1995-12-20 1999-12-28 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US5462939A (en) * 1993-05-07 1995-10-31 Sterling Winthrop Inc. Peptidic ketones as interleukin-1β-converting enzyme inhibitors
US5843905A (en) * 1993-06-04 1998-12-01 Vertex Pharmaceuticals, Incorporated Peptidic phosphinyloxymethyl ketones as interleukin-1β-converting enzyme inhibitors
US5714484A (en) * 1993-12-08 1998-02-03 Prototek, Inc. α-(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors
US5486623A (en) * 1993-12-08 1996-01-23 Prototek, Inc. Cysteine protease inhibitors containing heterocyclic leaving groups
US5798247A (en) * 1994-05-06 1998-08-25 Basf Aktiengesellschaft Organic-chemical compound with ice-inhibitory action
US5847135A (en) * 1994-06-17 1998-12-08 Vertex Pharmaceuticals, Incorporated Inhibitors of interleukin-1β converting enzyme
US5716929A (en) * 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US5756466A (en) * 1994-06-17 1998-05-26 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US6420522B1 (en) * 1995-06-05 2002-07-16 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US5585504A (en) * 1994-09-16 1996-12-17 Merck & Co., Inc. Process of making cox-2 inhibitors having a lactone bridge
WO1996029088A1 (en) * 1995-03-23 1996-09-26 Affymax Technologies N.V. Novel piperazine derivatives as type il-1 receptor antagonists
US6162828A (en) * 1995-03-31 2000-12-19 Takeda Chemical Industries, Ltd. Cysteine protease inhibitor
US6316486B1 (en) * 1995-05-09 2001-11-13 Bayer Aktiengesellschaft Alkyl dihalogenated phenyl-substituted ketoenols useful as pesticides and herbicides
DE19534016A1 (de) * 1995-09-14 1997-03-20 Merck Patent Gmbh Biotinderivate
US5843904A (en) * 1995-12-20 1998-12-01 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1βconverting enzyme
US5869519A (en) * 1996-12-16 1999-02-09 Idun Pharmaceuticals, Inc. C-terminal modified (n-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US5968927A (en) 1996-09-20 1999-10-19 Idun Pharmaceuticals, Inc. Tricyclic compounds for the inhibition of the ICE/ced-3 protease family of enzymes
US6184244B1 (en) 1996-12-16 2001-02-06 Idun Pharmaceuticals, Inc. C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US5877197A (en) * 1996-12-16 1999-03-02 Karanewsky; Donald S. C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
JP4439111B2 (ja) * 1997-10-10 2010-03-24 サイトビア インコーポレイテッド ジペプチドのアポトーシスインヒビターおよびそれらの使用
US6184210B1 (en) 1997-10-10 2001-02-06 Cytovia, Inc. Dipeptide apoptosis inhibitors and the use thereof
DE69925581T2 (de) 1998-03-09 2006-04-27 Vertex Pharmaceuticals Inc., Cambridge 1,2-diazepanderivate als inhibitoren des interleukin-1beta umwandelnden enzyms
ATE295177T1 (de) * 1998-03-16 2005-05-15 Cytovia Inc Dipeptid kaspase inhibitoren und deren verwendung
KR100928878B1 (ko) 1998-03-19 2009-11-30 버텍스 파마슈티칼스 인코포레이티드 카스파제의 억제제
US6242422B1 (en) 1998-10-22 2001-06-05 Idun Pharmacueticals, Inc. (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases
US7157430B2 (en) 1998-10-22 2007-01-02 Idun Pharmaceuticals, Inc. (Substituted)acyl dipeptidyl inhibitors of the ICE/CED-3 family of cysteine proteases
DE60030097T2 (de) 1999-03-16 2007-03-08 Cytovia, Inc., San Diego Substituierte 2-aminobenzamin caspase inhibitoren und ihre verwendung
BR0009610A (pt) 1999-04-09 2002-02-13 Cytovia Inc Inibidores de caspase e uso dos mesmos
EP1212295B1 (en) 1999-08-27 2008-10-01 Cytovia, Inc. Substituted alpha-hydroxy acid caspase inhibitors and the use thereof
US6566338B1 (en) 1999-10-12 2003-05-20 Cytovia, Inc. Caspase inhibitors for the treatment and prevention of chemotherapy and radiation therapy induced cell death
US6525024B1 (en) 2000-04-17 2003-02-25 Idun Pharmaceuticals, Inc. Inhibitors of the ICE/ced-3 family of cysteine proteases
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
JP2004521080A (ja) 2000-09-08 2004-07-15 メルク フロスト カナダ アンド カンパニー カスパーゼ−３阻害薬としてのγ−ケト酸ジペプチド類
AU2002314744A1 (en) * 2001-04-17 2002-10-28 Sepracor, Inc. Thiazole and other heterocyclic ligands and use thereof
DE10150203A1 (de) * 2001-10-12 2003-04-17 Probiodrug Ag Peptidylketone als Inhibitoren der DPIV
US7410956B2 (en) * 2002-02-11 2008-08-12 Vertex Pharmaceuticals Incorporated Caspase inhibitor prodrugs
AU2005247409B2 (en) * 2004-05-15 2011-11-10 Vertex Pharmaceuticals Incorporated Treating seizures using ICE inhibitors
EP1778221A2 (en) * 2004-05-27 2007-05-02 Vertex Pharmaceuticals Incorporated Ice inhibitors for the treatment of autoinflammatory diseases
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055451A (en) * 1986-12-22 1991-10-08 Syntex Inc. Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors
DE3737399A1 (de) * 1987-11-04 1989-05-18 Schwabe Willmar Gmbh & Co Aminosaeureester, verfahren zu ihrer herstellung und ihre verwendung
WO1991015577A1 (en) * 1990-04-04 1991-10-17 Black, Roy, A. INTERLEUKIN 1'beta' PROTEASE
DE69226820T2 (de) * 1991-06-21 1999-05-12 Merck & Co., Inc., Rahway, N.J. Peptidylderivate als Inhibitoren von Interleukin-1B-konvertierenden Enzymen
CA2111100C (en) * 1991-08-30 2004-11-02 Roy A. Black Interleukin-1 beta protease and interleukin-1 beta protease inhibitors
GB9123326D0 (en) * 1991-11-04 1991-12-18 Sandoz Ltd Improvements in or relating to organic compounds
AU3666893A (en) * 1992-02-21 1993-09-13 Merck & Co., Inc. Peptidyl derivatives as inhibitors of interleukin-1beta converting enzyme
US5462939A (en) * 1993-05-07 1995-10-31 Sterling Winthrop Inc. Peptidic ketones as interleukin-1β-converting enzyme inhibitors

Also Published As

Publication number Publication date
DK0623606T3 (da) 1998-09-07
DE69407654T2 (de) 1999-01-21
AU668465B2 (en) 1996-05-02
SK282270B6 (sk) 2001-12-03
ES2113606T3 (es) 1998-05-01
EP0623606B1 (en) 1998-01-07
CA2123055A1 (en) 1994-11-08
NZ260477A (en) 1995-12-21
ATE161849T1 (de) 1998-01-15
EP0623606A2 (en) 1994-11-09
NO941675D0 (no) 1994-05-06
TW377350B (en) 1999-12-21
US5585486A (en) 1996-12-17
GR3026556T3 (en) 1998-07-31
DE69407654D1 (de) 1998-02-12
SK50994A3 (en) 1995-02-08
RU2133251C1 (ru) 1999-07-20
PH30362A (en) 1997-04-02
EP0623606A3 (en) 1994-12-07
CZ108394A3 (en) 1994-12-15
FI942107A0 (fi) 1994-05-06
HU9401423D0 (en) 1994-08-29
HU217070B (hu) 1999-11-29
US5462939A (en) 1995-10-31
JPH0725839A (ja) 1995-01-27
AU6190694A (en) 1994-11-10
FI942107A (fi) 1994-11-08
HK1008146A1 (en) 1999-04-30
IL109585A0 (en) 1994-08-26
HUT68791A (en) 1995-07-28

Similar Documents

Publication Publication Date Title
NO941675D0 (no) Peptid-ketoner som inhibitorer av interleukin-1beta-omdannede enzym
RU94015842A (ru) Пептидные кетоны, фармацевтическая композиция и способ ингибирования интерлейкин-1 протеазы
FI942005A0 (fi) Peptidianalogeja irreversiibeleinä interleukiini-1beta-proteaasi-inhibiittoreina
NZ501346A (en) Valinyl aromatic beta amino acid dipeptide compounds having fungicidal activity and their agronomic use
NZ296479A (en) Amino acid or peptide derivatives which are inhibitors of multicatalytic protease (mcp)
KR910020031A (ko) 펩티드 아미드, 이의 제조방법 및 피브린/트롬빈 응괴 억제제로서 이를 함유하는 약제
NZ336046A (en) Serine protease inhibitors containing substituted oxadiazole, thiadiazole and triazole peptide derivatives
NZ334906A (en) A sulphonamido pentanoic acid derivative useful as an interleukin-1-beta converting enzyme inhibitor
DK0930883T3 (da) Neurotrofinantagonister til behandling af epilepsi, Alzheimers sygdom og smerte
ES2053525T3 (es) Acidos hidroxamicos.
EP1374863A4 (en) AMINO ACID COMPOSITIONS USED TO IMPROVE HEPATIC INSUFFICIENCY
CA2215827A1 (en) O-malonyltyrosyl compounds, o-malonyltyrosyl compound-containing peptides, and uses thereof
DK0655056T3 (da) N-(Dihydroxyalkyl) -ethynylalanin-amider med azacyclyl-endegruppe til behandling af hypertension
DK0431520T3 (da) Heterocycliske acylaminodiol-beta-aminosyrederivater
Dolle et al. Peptidic ketones as interleukin-1 beta-converting enzyme inhibitors
Dolle et al. Peptidic ketones as interleukin-1 beta-converting enzyme inhibitors
FR2669339B1 (fr) Nouveaux derives peptidiques, procede de preparation et application a titre de medicaments de ces nouveaux derives.
DK0854862T3 (da) Fremgangsmåde til fremstillingen af en aktiveret aminosyre
DK0955310T3 (da) Hidtil ukendte (3,4,7,8,9,10)-hexahydro-6,10-dioxo-6H-pyridazino[1,2-a][1,2]diazepin-1-carboxylsyrederivater, fremgangsmåde til fremstilling af disse og anvendelse af disse til fremstilling af lægemidler
DK0655063T3 (da) Ethynyl-alanin-aminodiolforbindelser med piperazinyl-endegruppe eller piperazinylamino-endegruppe til behandling af hyperte
MX9700828A (es) Analogos del acido aspartico como inhibidores de la enzima que convierte a la interleucina-1 beta.
DK1155138T3 (da) Fremgangsmåde til fremstilling af optisk aktive 3,3,3-trifluormethyl-2-alkylpropionsyrederivater
TH13640A (th) Hemoregulatory peptides เปปไทด์ที่ควบคุม