PH27365A - Di-and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase - Google Patents

Di-and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase

Info

Publication number
PH27365A
PH27365A PH27365A PH27365A PH27365A PH 27365 A PH27365 A PH 27365A PH 27365 A PH27365 A PH 27365A PH 27365 A PH27365 A PH 27365A PH 27365 A PH27365 A PH 27365A
Authority
PH
Philippines
Prior art keywords
squalene
tetra
inhibitors
fluoro analogs
epoxidase
Prior art date
Application number
PH27365A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of PH27365A publication Critical patent/PH27365A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C21/00—Acyclic unsaturated compounds containing halogen atoms
    • C07C21/02—Acyclic unsaturated compounds containing halogen atoms containing carbon-to-carbon double bonds
    • C07C21/215—Halogenated polyenes with more than two carbon-to-carbon double bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Steroid Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
PH27365A 1990-03-30 1993-06-21 Di-and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase PH27365A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/502,203 US5011859A (en) 1990-03-30 1990-03-30 Di- and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase

Publications (1)

Publication Number Publication Date
PH27365A true PH27365A (en) 1993-06-21

Family

ID=23996803

Family Applications (1)

Application Number Title Priority Date Filing Date
PH27365A PH27365A (en) 1990-03-30 1993-06-21 Di-and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase

Country Status (19)

Country Link
US (1) US5011859A (no)
EP (1) EP0448934B1 (no)
JP (1) JP2911239B2 (no)
KR (1) KR0162659B1 (no)
CN (1) CN1055172A (no)
AT (1) ATE118756T1 (no)
AU (1) AU629726B2 (no)
CA (1) CA2034612C (no)
DE (1) DE69107488T2 (no)
ES (1) ES2071131T3 (no)
FI (1) FI910425A (no)
HU (1) HU208103B (no)
IE (1) IE910181A1 (no)
IL (1) IL97356A0 (no)
NO (1) NO910263L (no)
NZ (1) NZ236800A (no)
PH (1) PH27365A (no)
PT (1) PT96654A (no)
ZA (1) ZA91392B (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995004025A1 (fr) * 1993-07-29 1995-02-09 Chugai Seiyaku Kabushiki Kaisha Derive d'acide tricarboxylique a activite d'inhibition de la squalene-synthetase
DE19754795A1 (de) * 1997-12-10 1999-06-17 Boehringer Ingelheim Pharma Neue Urethane, ihre Thio- und Dithioanaloga, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung
US6103733A (en) * 1998-09-09 2000-08-15 Bachmann; Kenneth A. Method for increasing HDL cholesterol levels using heteroaromatic phenylmethanes
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
TW200831497A (en) * 2006-10-12 2008-08-01 Epix Delaware Inc Carboxamide compounds and their use
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
US20100331298A1 (en) * 2007-12-10 2010-12-30 Cytopathfinder, Inc. Carboxamide Compounds and Their Use
KR20100102646A (ko) 2007-12-11 2010-09-24 가부시키가이샤 사이토파스파인더 카르복스아미드 화합물 및 케모카인 수용체 길항제로서의 이의 용도
EP2571860A1 (en) 2010-05-21 2013-03-27 Pfizer Inc 2-phenyl benzoylamides
US20130345392A1 (en) 2011-03-04 2013-12-26 Pfizer Inc Edn3-like peptides and uses thereof
EP2986599A1 (en) 2013-04-17 2016-02-24 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
CA3125765A1 (en) 2019-01-18 2020-07-23 Astrazeneca Ab Pcsk9 inhibitors and methods of use thereof
CN112678833B (zh) * 2020-11-17 2023-08-04 广西中烟工业有限责任公司 纳米二氧化硅改性角鲨烯有机硅颗粒及其制备和使用方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3876672A (en) * 1972-02-21 1975-04-08 Du Pont Hydroformylation of olefins
DE2913677C2 (de) * 1979-04-05 1983-03-03 Union Rheinische Braunkohlen Kraftstoff AG, 5000 Köln Verfahren zur Herstellung von Acetaldehyddimethylacetal
US4455441A (en) * 1982-09-24 1984-06-19 Research Foundation Of State University Of New York Attractant termiticidal compounds, compositions and methods of use therefor
DE3618115A1 (de) * 1986-05-30 1987-12-03 Bayer Ag Halogenolefine
US4876295A (en) * 1987-03-11 1989-10-24 The Dow Chemical Company Flexible thermoplastic epoxy resin and coatings prepared therefrom

Also Published As

Publication number Publication date
DE69107488T2 (de) 1995-06-14
EP0448934A3 (en) 1991-11-27
CN1055172A (zh) 1991-10-09
AU629726B2 (en) 1992-10-08
PT96654A (pt) 1991-10-31
EP0448934A2 (en) 1991-10-02
IL97356A0 (en) 1992-05-25
FI910425A0 (fi) 1991-01-29
ATE118756T1 (de) 1995-03-15
IE910181A1 (en) 1991-10-09
ES2071131T3 (es) 1995-06-16
NZ236800A (en) 1993-05-26
NO910263L (no) 1991-10-01
KR910016660A (ko) 1991-11-05
NO910263D0 (no) 1991-01-23
KR0162659B1 (ko) 1999-01-15
CA2034612C (en) 2001-05-15
CA2034612A1 (en) 1991-10-01
HUT56533A (en) 1991-09-30
ZA91392B (en) 1991-10-30
HU910174D0 (en) 1991-08-28
FI910425A (fi) 1991-10-01
JP2911239B2 (ja) 1999-06-23
DE69107488D1 (de) 1995-03-30
JPH04221327A (ja) 1992-08-11
HU208103B (en) 1993-08-30
AU6946891A (en) 1991-10-03
EP0448934B1 (en) 1995-02-22
US5011859A (en) 1991-04-30

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