PH26978A - Method of using (2-imidazolin-2-ylamino)quinozalines to reduce or maintain intraocular pressure - Google Patents
Method of using (2-imidazolin-2-ylamino)quinozalines to reduce or maintain intraocular pressure Download PDFInfo
- Publication number
- PH26978A PH26978A PH41224A PH41224A PH26978A PH 26978 A PH26978 A PH 26978A PH 41224 A PH41224 A PH 41224A PH 41224 A PH41224 A PH 41224A PH 26978 A PH26978 A PH 26978A
- Authority
- PH
- Philippines
- Prior art keywords
- compound
- group
- mammalian eye
- intraocular pressure
- imidazolin
- Prior art date
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- -1 2-imidazolin-2-ylamino Chemical group 0.000 title claims abstract description 30
- 230000004410 intraocular pressure Effects 0.000 title claims abstract description 30
- 238000000034 method Methods 0.000 title claims description 42
- 150000001875 compounds Chemical class 0.000 claims abstract description 47
- 239000000203 mixture Substances 0.000 claims abstract description 25
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 22
- 208000010412 Glaucoma Diseases 0.000 claims abstract description 17
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims abstract description 16
- 150000003839 salts Chemical class 0.000 claims abstract description 11
- 239000002253 acid Substances 0.000 claims abstract description 10
- 229910052794 bromium Inorganic materials 0.000 claims abstract description 8
- 229910052801 chlorine Inorganic materials 0.000 claims abstract description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 14
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical group [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 3
- 125000004429 atom Chemical group 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 abstract description 10
- 239000003814 drug Substances 0.000 abstract description 7
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- 230000000699 topical effect Effects 0.000 abstract description 5
- 150000002431 hydrogen Chemical group 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
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- QZUXRMOPAGPTIY-UHFFFAOYSA-N n-(4,5-dihydro-1h-imidazol-2-yl)-5-methylquinoxalin-6-amine Chemical compound C1=CC2=NC=CN=C2C(C)=C1NC1=NCCN1 QZUXRMOPAGPTIY-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/429,835 US5021416A (en) | 1989-10-31 | 1989-10-31 | Method for using (2-imidazolin-2-ylamino) quinoxalines to reduce or maintain intraocular pressure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH26978A true PH26978A (en) | 1992-12-28 |
Family
ID=23704912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH41224A PH26978A (en) | 1989-10-31 | 1990-09-19 | Method of using (2-imidazolin-2-ylamino)quinozalines to reduce or maintain intraocular pressure |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5021416A (ja) |
| EP (1) | EP0426390B1 (ja) |
| JP (1) | JP2999240B2 (ja) |
| KR (1) | KR910007530A (ja) |
| AT (1) | ATE122233T1 (ja) |
| AU (1) | AU627626B2 (ja) |
| CA (1) | CA2025189A1 (ja) |
| DE (1) | DE69019297T2 (ja) |
| ES (1) | ES2074138T3 (ja) |
| FI (1) | FI905369A0 (ja) |
| HU (1) | HU207946B (ja) |
| IE (1) | IE68413B1 (ja) |
| IL (1) | IL96083A (ja) |
| NZ (1) | NZ235884A (ja) |
| PH (1) | PH26978A (ja) |
| RU (1) | RU1829937C (ja) |
| TW (1) | TW218352B (ja) |
| ZA (1) | ZA908731B (ja) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5077292A (en) * | 1989-10-12 | 1991-12-31 | Allergan, Inc. | (2-imidazolin-2-ylamino) tetrahydroquinoxalines and methods for using same |
| US5112822A (en) * | 1989-10-12 | 1992-05-12 | Allergan, Inc. | (2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same |
| US5231096A (en) * | 1989-10-12 | 1993-07-27 | Allergan, Inc. | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives |
| US5326763A (en) * | 1989-10-12 | 1994-07-05 | Allergan, Inc. | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives |
| US6323204B1 (en) | 1993-10-13 | 2001-11-27 | Allergan | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives |
| EP1285657A3 (en) * | 1993-10-13 | 2003-08-20 | Allergan, Inc. | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives |
| US5478858A (en) * | 1993-12-17 | 1995-12-26 | The Procter & Gamble Company | 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists |
| CN1046718C (zh) * | 1993-12-17 | 1999-11-24 | 普罗克特和甘保尔公司 | 用作α－2肾上腺素能受体兴奋剂的6－(2－亚咪唑烷基氨基)喹啉化合物 |
| CA2179006A1 (en) * | 1993-12-17 | 1995-06-22 | Peter Julian Maurer | 6-(2-imidazolinylamino)quinoxaline compounds useful as alpha-2 adrenoceptor agonists |
| US5576437A (en) * | 1993-12-17 | 1996-11-19 | The Procter & Gamble Company | 7-(2-imidazolnylamino) quinoline compounds useful as alpha-2 adrenoceptor agonists |
| US5578607A (en) * | 1993-12-17 | 1996-11-26 | The Procter & Gamble Company | 6-(2-imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists |
| US6294563B1 (en) | 1994-10-27 | 2001-09-25 | Allergan Sales, Inc. | Combinations of prostaglandins and brimonidine or derivatives thereof |
| US5856329A (en) * | 1995-06-28 | 1999-01-05 | Allergan | Method of using (2-imidazolin-2-ylamino) quinoxalines in treating ocular neural injury |
| US6194415B1 (en) | 1995-06-28 | 2001-02-27 | Allergan Sales, Inc. | Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury |
| US5916900A (en) * | 1995-06-29 | 1999-06-29 | The Procter & Gamble Company | 7-(2-imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists |
| JP2001524478A (ja) | 1997-11-24 | 2001-12-04 | ザ プロクター アンド ギャンブル カンパニー | ５−（２−イミダゾリニルアミノ）−ベンゾイミダゾール誘導体類、それらの調製および改良された代謝安定性を有するアルファアドレナリン受容体作動薬としてのそれらの使用 |
| US6329369B1 (en) | 1997-12-04 | 2001-12-11 | Allergan Sales, Inc. | Methods of treating pain and other conditions |
| US6841684B2 (en) | 1997-12-04 | 2005-01-11 | Allergan, Inc. | Imidiazoles having reduced side effects |
| US20040214829A1 (en) * | 2000-07-14 | 2004-10-28 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
| US8858961B2 (en) * | 2000-07-14 | 2014-10-14 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
| DK2153819T3 (da) * | 2000-07-14 | 2012-12-03 | Allergan Inc | Anvendelse af en opløselighedsforbedrende bestanddel i en vandig sammensætning omfattende brimonidintartrat |
| US20050026924A1 (en) * | 2000-07-14 | 2005-02-03 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
| HUP0303197A3 (en) | 2000-07-14 | 2008-03-28 | Allergan Inc | Compositions containing alpha-2 adrenergic agonist components |
| US20020198209A1 (en) * | 2001-05-03 | 2002-12-26 | Allergan Sales Inc. | Compositions having enhanced pharmacokinetic characteristics |
| US20020198210A1 (en) * | 2001-05-03 | 2002-12-26 | Allergan Sales Inc. | Alpha-2-adrenergic agonist/fatty acid compositions |
| AU2002256471B2 (en) * | 2001-05-03 | 2007-05-24 | Allergan, Inc. | Compositions having enhanced pharmacokinetic characteristics |
| US7030149B2 (en) | 2002-04-19 | 2006-04-18 | Allergan, Inc. | Combination of brimonidine timolol for topical ophthalmic use |
| US20040191332A1 (en) * | 2003-03-27 | 2004-09-30 | Allergan, Inc. | Preserved ophthalmic compositions |
| US8410102B2 (en) | 2003-05-27 | 2013-04-02 | Galderma Laboratories Inc. | Methods and compositions for treating or preventing erythema |
| US7439241B2 (en) | 2003-05-27 | 2008-10-21 | Galderma Laboratories, Inc. | Compounds, formulations, and methods for treating or preventing rosacea |
| DK1654002T4 (da) | 2003-08-07 | 2014-02-17 | Allergan Inc | Sammensætninger til fremføring af terapeutiske midler til øjnene |
| WO2008144399A1 (en) * | 2007-05-18 | 2008-11-27 | Bausch & Lomb Incorporated | COMPLEXES COMPRISING α2-ADRENERGIC RECEPTOR AGONISTS AND COMPOSITIONS |
| US7842714B2 (en) | 2008-03-03 | 2010-11-30 | Allergan, Inc. | Ketorolac tromethamine compositions for treating ocular pain |
| US9192571B2 (en) * | 2008-03-03 | 2015-11-24 | Allergan, Inc. | Ketorolac tromethamine compositions for treating or preventing ocular pain |
| US20110003823A1 (en) * | 2008-08-01 | 2011-01-06 | Alpha Synergy Development, Inc. | Compositions and methods for treatment of diseases and conditions associated with vasodilation and/or vascular leakage |
| US20100203165A1 (en) * | 2008-08-01 | 2010-08-12 | Gerald Horn | Compositions and methods for treatment of disorders or conditions of the eye |
| US20100197694A1 (en) * | 2008-08-01 | 2010-08-05 | Gerald Horn | Compositions and methods for treatment of diseases and conditions with increased vascular permeability |
| EP2320911B1 (en) * | 2008-08-01 | 2014-10-08 | Eye Therapies LLC | Vasoconstriction compositions and methods of use |
| US20180369240A1 (en) * | 2008-08-01 | 2018-12-27 | Eye Therapies Llc | Preferential Vasoconstriction Compositions and Methods of Use |
| US8952011B2 (en) | 2008-08-01 | 2015-02-10 | Eye Therapies Llc | Compositions and methods for the treatment of nasal conditions |
| US20100202979A1 (en) * | 2008-08-01 | 2010-08-12 | Gerald Horn | Compositions and methods for treatment of pulmonary diseases and conditions |
| US8987270B2 (en) | 2009-07-27 | 2015-03-24 | Eye Therapies Llc | Formulations of selective alpha-2 agonists and methods of use thereof |
| EP2329849B1 (en) | 2009-11-18 | 2015-04-29 | Galderma Research & Development | Combination of alpha-2 adrenergic receptor agonist and non-steroidal anti-inflammatory agent for treating or preventing an inflammatory skin disorder |
| US8394800B2 (en) * | 2009-11-19 | 2013-03-12 | Galderma Laboratories, L.P. | Method for treating psoriasis |
| US9522153B2 (en) | 2009-12-22 | 2016-12-20 | Allergan, Inc. | Compositions and methods for lowering intraocular pressure |
| CN103096894A (zh) | 2010-03-26 | 2013-05-08 | 盖尔德马研究及发展公司 | 用于治疗红斑的包含溴莫尼定的组合物 |
| KR20170018974A (ko) | 2010-03-26 | 2017-02-20 | 갈데르마 리써어치 앤드 디벨로프먼트 | 홍반의 유효하고 안전한 치료를 위한 개선된 방법 및 조성물 |
| KR20130092957A (ko) | 2010-04-07 | 2013-08-21 | 알러간, 인코포레이티드 | 안과용 처방용 보존제 조성물의 조합 |
| CN102883708A (zh) | 2010-04-07 | 2013-01-16 | 阿勒根公司 | 用于眼用组合物的防腐剂联合 |
| EP2598119B1 (en) | 2010-07-29 | 2018-09-19 | Allergan, Inc. | Preservative free brimonidine and timolol solutions |
| US8053427B1 (en) | 2010-10-21 | 2011-11-08 | Galderma R&D SNC | Brimonidine gel composition |
| AR083651A1 (es) | 2010-10-21 | 2013-03-13 | Galderma Sa | Composiciones de brimonidina en gel y metodos de uso |
| JP6339364B2 (ja) * | 2013-12-27 | 2018-06-06 | カズマパートナーズ株式会社 | 無定形ブリモニジン酒石酸塩及びその製造方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE795970A (fr) * | 1972-02-29 | 1973-08-27 | Pfizer | Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant |
| GB1463520A (en) * | 1974-09-06 | 1977-02-02 | Pfizer Ltd | Process for the production of imidazolines |
| US5077292A (en) * | 1989-10-12 | 1991-12-31 | Allergan, Inc. | (2-imidazolin-2-ylamino) tetrahydroquinoxalines and methods for using same |
-
1989
- 1989-10-31 US US07/429,835 patent/US5021416A/en not_active Expired - Lifetime
-
1990
- 1990-09-12 CA CA002025189A patent/CA2025189A1/en not_active Abandoned
- 1990-09-19 PH PH41224A patent/PH26978A/en unknown
- 1990-10-05 TW TW079108344A patent/TW218352B/zh active
- 1990-10-10 AU AU63966/90A patent/AU627626B2/en not_active Ceased
- 1990-10-15 ZA ZA908731A patent/ZA908731B/xx unknown
- 1990-10-22 IL IL96083A patent/IL96083A/xx not_active IP Right Cessation
- 1990-10-26 EP EP90311755A patent/EP0426390B1/en not_active Expired - Lifetime
- 1990-10-26 ES ES90311755T patent/ES2074138T3/es not_active Expired - Lifetime
- 1990-10-26 DE DE69019297T patent/DE69019297T2/de not_active Expired - Fee Related
- 1990-10-26 AT AT90311755T patent/ATE122233T1/de not_active IP Right Cessation
- 1990-10-30 IE IE389690A patent/IE68413B1/en not_active IP Right Cessation
- 1990-10-30 FI FI905369A patent/FI905369A0/fi not_active Application Discontinuation
- 1990-10-30 NZ NZ235884A patent/NZ235884A/xx unknown
- 1990-10-30 HU HU906934A patent/HU207946B/hu not_active IP Right Cessation
- 1990-10-31 RU SU904831722A patent/RU1829937C/ru active
- 1990-10-31 KR KR1019900017735A patent/KR910007530A/ko not_active Application Discontinuation
- 1990-10-31 JP JP2297019A patent/JP2999240B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU6396690A (en) | 1991-05-09 |
| NZ235884A (en) | 1997-08-22 |
| HU906934D0 (en) | 1991-05-28 |
| US5021416A (en) | 1991-06-04 |
| RU1829937C (ru) | 1993-07-23 |
| TW218352B (ja) | 1994-01-01 |
| DE69019297D1 (de) | 1995-06-14 |
| IL96083A (en) | 1997-06-10 |
| CA2025189A1 (en) | 1991-05-01 |
| ATE122233T1 (de) | 1995-05-15 |
| JPH03153626A (ja) | 1991-07-01 |
| EP0426390A2 (en) | 1991-05-08 |
| IL96083A0 (en) | 1991-07-18 |
| EP0426390A3 (en) | 1992-03-04 |
| EP0426390B1 (en) | 1995-05-10 |
| HUT57045A (en) | 1991-11-28 |
| FI905369A0 (fi) | 1990-10-30 |
| KR910007530A (ko) | 1991-05-30 |
| ES2074138T3 (es) | 1995-09-01 |
| JP2999240B2 (ja) | 2000-01-17 |
| DE69019297T2 (de) | 1995-10-12 |
| ZA908731B (en) | 1991-07-31 |
| IE903896A1 (en) | 1991-05-08 |
| AU627626B2 (en) | 1992-08-27 |
| IE68413B1 (en) | 1996-06-12 |
| HU207946B (en) | 1993-07-28 |
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