PH23172A - Improvements in the treatment of tumors in mammals - Google Patents

Improvements in the treatment of tumors in mammals

Info

Publication number
PH23172A
PH23172A PH33109A PH33109A PH23172A PH 23172 A PH23172 A PH 23172A PH 33109 A PH33109 A PH 33109A PH 33109 A PH33109 A PH 33109A PH 23172 A PH23172 A PH 23172A
Authority
PH
Philippines
Prior art keywords
mammals
tumors
treatment
difluoronucleosides
useful
Prior art date
Application number
PH33109A
Other languages
English (en)
Inventor
Gerald Burr Grindey
Larry Wayne Hertel
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27101898&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PH23172(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PH23172A publication Critical patent/PH23172A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PH33109A 1984-12-04 1985-11-28 Improvements in the treatment of tumors in mammals PH23172A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67778384A 1984-12-04 1984-12-04
US78641985A 1985-10-10 1985-10-10

Publications (1)

Publication Number Publication Date
PH23172A true PH23172A (en) 1989-05-19

Family

ID=27101898

Family Applications (1)

Application Number Title Priority Date Filing Date
PH33109A PH23172A (en) 1984-12-04 1985-11-28 Improvements in the treatment of tumors in mammals

Country Status (21)

Country Link
US (1) US5464826A (fr)
EP (1) EP0184365B1 (fr)
JP (1) JPH0637394B2 (fr)
KR (2) KR890003439B1 (fr)
CN (1) CN1020194C (fr)
AT (1) ATE92499T1 (fr)
AU (1) AU581269B2 (fr)
CA (1) CA1264738A (fr)
CY (1) CY1806A (fr)
DE (1) DE3587500T2 (fr)
DK (1) DK162965C (fr)
EG (1) EG17765A (fr)
ES (1) ES8801546A1 (fr)
GR (1) GR852858B (fr)
HK (1) HK113693A (fr)
HU (1) HU194273B (fr)
IE (1) IE60328B1 (fr)
IL (1) IL77133A (fr)
NZ (1) NZ214364A (fr)
PH (1) PH23172A (fr)
PT (1) PT81559B (fr)

Families Citing this family (150)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1269659A (fr) * 1984-08-06 1990-05-29 Brigham Young University Preparation de composes a base de 2'-desoxyadenosine
CA1295998C (fr) * 1985-07-29 1992-02-18 Sai P. Sunkara Nucleosides et leur utilisation en tant qu'agents antineoplasiques
RU1787160C (ru) * 1986-12-24 1993-01-07 Эли Лилли Энд Компани Способ получени иммуноглобулинового конъюгата
US4814438A (en) * 1986-12-24 1989-03-21 Eli Lilly And Company Immunoglobulin conjugates of 2',2'-difluronucleosides
US4994558A (en) * 1986-12-24 1991-02-19 Eli Lilly And Company Immunoglobulin conjugates
US5223608A (en) * 1987-08-28 1993-06-29 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
DE3856330T2 (de) * 1987-08-28 1999-09-30 Lilly Co Eli Verfahren zur selektiven Isolierung von beta-2'-desoxy-2'2'-difluorocytidin oder seiner Salze
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US4914028A (en) * 1988-02-10 1990-04-03 Eli Lilly And Company Method of preparing beta-2',2'-difluoronucleosides
ES2075040T3 (es) * 1988-02-16 1995-10-01 Lilly Co Eli 2',3'-dideoxi-2',2'-difluoronucleosidos.
US5644043A (en) * 1988-02-16 1997-07-01 Eli Lilly And Company 2',3'-dideoxy-2',2'-difluoronucleosides and intermediates
US4996308A (en) * 1988-03-25 1991-02-26 Merrell Dow Pharmaceuticals Inc. Derivatives with unsaturated substitutions for the 5'-hydroxymethyl group
JPH0232093A (ja) * 1988-06-08 1990-02-01 Merrell Dow Pharmaceut Inc 抗レトロウィルスジフルオロ化ヌクレオシド類
CA2004695C (fr) * 1988-12-12 1999-08-10 Rosanne Bonjouklian Phospholipide nucleosides
YU43193A (sh) * 1992-06-22 1997-01-08 Eli Lilly And Company 2'-deoksi-2',2'-difluoro(4-supstituisani)pirimidinski nukleozidi antivirusnog i antikancerogenog dejstva i međuproizvodi
AU4134793A (en) * 1992-06-22 1993-12-23 Eli Lilly And Company 2'-deoxy-2',2'-difluoro(2,6,8-substituted) purine nucleosides having anti-viral and anti-cancer activity and intermediates
AU671491B2 (en) * 1992-12-18 1996-08-29 F. Hoffmann-La Roche Ag N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines
US5424416A (en) * 1993-08-25 1995-06-13 Eli Lilly And Company Process for preparation of 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonates and their use in preparation of 2',2'-difluoro-2'-deoxy nucleosides
US5480992A (en) * 1993-09-16 1996-01-02 Eli Lilly And Company Anomeric fluororibosyl amines
US5637688A (en) * 1994-12-13 1997-06-10 Eli Lilly And Company Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride
US5559222A (en) * 1995-02-03 1996-09-24 Eli Lilly And Company Preparation of 1-(2'-deoxy-2',2'-difluoro-D-ribo-pentofuranosyl)-cytosine from 2-deoxy-2,2-difluoro-β-D-ribo-pentopyranose
KR100483256B1 (ko) * 1997-01-24 2005-04-15 콘파마 아에스 젬시타빈 유도체
JP2001518931A (ja) * 1997-03-24 2001-10-16 イーライ・リリー・アンド・カンパニー ジフルオロヌクレオシドホスホン酸とその誘導体
TW466112B (en) * 1998-04-14 2001-12-01 Lilly Co Eli Novel use of 2'-deoxy-2',2'-difluorocytidine for immunosuppressive therapy and pharmaceutical composition comprising the same
US6326507B1 (en) * 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US20050281821A1 (en) * 1999-01-06 2005-12-22 Flavia Pernasetti Method and composition for angiogenesis inhibition
WO2000076497A1 (fr) * 1999-06-14 2000-12-21 Cancer Research Ventures Limited Therapie anticancereuse
AU2001282717A1 (en) * 2000-07-28 2002-02-13 Cancer Research Technology Limited Cancer treatment by combination therapy
GB0019124D0 (en) * 2000-08-03 2000-09-27 Pfizer Novel process
EP1415987B1 (fr) * 2000-10-20 2007-02-28 Eisai R&D Management Co., Ltd. Composes heteroaromatiques azotes pour le traitement des maladies de cancer
US6822001B2 (en) * 2000-11-03 2004-11-23 Tularik Inc. Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
US20050250854A1 (en) * 2000-11-03 2005-11-10 Amgen Inc. Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
US7435755B2 (en) 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
GB0121285D0 (en) * 2001-09-03 2001-10-24 Cancer Res Ventures Ltd Anti-cancer combinations
US20030139373A1 (en) * 2001-11-20 2003-07-24 Breimer Lars Holger Method for cancer therapy
US7390885B2 (en) * 2001-11-26 2008-06-24 Cell Matrix, Inc. Humanized collagen antibodies and related methods
US7365167B2 (en) * 2001-11-26 2008-04-29 Cell Matrix, Inc. Humanized collagen antibodies and related methods
EP1469847A1 (fr) * 2002-01-14 2004-10-27 Novartis AG Combinaisons comprenant des epothilones et des antimetabolites
WO2003059339A1 (fr) * 2002-01-15 2003-07-24 Trustees Of Dartmouth College Derives de bis- enone tricyclique et methodes d'utilisation
MXPA04007876A (es) * 2002-02-14 2005-06-20 Pharmasset Ltd Analogos de nucleosido fluorado modificados.
GB2386836B (en) * 2002-03-22 2006-07-26 Cancer Res Ventures Ltd Anti-cancer combinations
GB0223380D0 (en) * 2002-10-09 2002-11-13 Astrazeneca Ab Combination therapy
GB2394658A (en) * 2002-11-01 2004-05-05 Cancer Rec Tech Ltd Oral anti-cancer composition
US7994159B2 (en) * 2003-03-10 2011-08-09 Eisai R&D Management Co., Ltd. c-Kit kinase inhibitor
WO2004105732A1 (fr) * 2003-05-20 2004-12-09 Aronex Pharmaceuticals, Inc. Chimiotherapie combinee contenant gemcitabine et un complexe liposomique a base de platine
EP1631278A4 (fr) * 2003-05-20 2006-09-20 Aronex Pharmaceuticals Inc Chimiotherapie combinee comprenant capecitabine et un complexe a base de platine liposomique
DE10323279A1 (de) * 2003-05-21 2004-12-16 Stada Arzneimittel Ag Gebrauchsfertige Gemcitabin-Lösungen
GB0321999D0 (en) * 2003-09-19 2003-10-22 Cancer Rec Tech Ltd Anti-cancer combinations
JP4303726B2 (ja) * 2003-11-11 2009-07-29 エーザイ・アール・アンド・ディー・マネジメント株式会社 ウレア誘導体およびその製造方法
US8318683B2 (en) * 2004-02-06 2012-11-27 Threshold Pharmaceuticals, Inc. Anti-cancer therapies
ES2308488T3 (es) * 2004-04-22 2008-12-01 Eli Lilly And Company Composicion que comprende un oligonucleotido antisentido de survivina y gemcitabina para el tratamiento de cancer.
JP4834553B2 (ja) * 2004-09-17 2011-12-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 医薬組成物
US20060089328A1 (en) * 2004-10-22 2006-04-27 Edgar Schridde Ready-to-use gemcitabine solutions
US20060089329A1 (en) * 2004-10-22 2006-04-27 Edgar Schridde Ready-to-use gemcitabine solution concentrates
US7563570B2 (en) * 2004-10-29 2009-07-21 Pangaea Biotech Method of determining a chemotherapeutic regimen for non small cell lung cancer based on BRCA1 expression
WO2006063105A1 (fr) * 2004-12-08 2006-06-15 Sicor Inc. Difluoronucleosides et procede de preparation de ceux-ci
DE102004063347A1 (de) * 2004-12-23 2006-07-13 Stada Arzneimittel Ag Gebrauchsfertige Gemcitabinlösungen und Gemcitabinlösungskonzentrate
MY142304A (en) 2005-01-31 2010-11-15 Taiho Pharmaceutical Co Ltd Novel pyrimidine nucleoside compound or salt thereof
DE602005019626D1 (de) * 2005-03-04 2010-04-08 Fresenius Kabi Oncology Ltd Zwischenprodukt und verfahren zur herstellung von an beta-anomeren angereicherten 2'-desoxy,2',2'-difluor-d-ribufuranosylnukleosiden
US7485716B2 (en) 2005-05-02 2009-02-03 Pharmaessentia Corp. Stereoselective synthesis of β-nucleosides
US20100105031A1 (en) * 2005-08-01 2010-04-29 Esai R & D Management Co., Ltd. Method for prediction of the efficacy of vascularization inhibitor
JP4989476B2 (ja) 2005-08-02 2012-08-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 血管新生阻害物質の効果を検定する方法
WO2007024921A2 (fr) * 2005-08-24 2007-03-01 Cell Matrix Therapies combinees visant a inhiber les interactions integrine-matrice extracellulaire
JP2009506019A (ja) * 2005-08-26 2009-02-12 アンティソーマ・ピーエルシー 癌治療のための組み合わせ
CA2627598C (fr) * 2005-11-07 2013-06-25 Eisai R & D Management Co., Ltd. Utilisation d'une combinaison de substance anti-angiogenique et d'inhibiteur de kinase c-kit
WO2007061130A1 (fr) * 2005-11-22 2007-05-31 Eisai R & D Management Co., Ltd. Agent antitumeur pour myelomes multiples
JP5190361B2 (ja) 2006-05-18 2013-04-24 エーザイ・アール・アンド・ディー・マネジメント株式会社 甲状腺癌に対する抗腫瘍剤
US20090203693A1 (en) * 2006-06-29 2009-08-13 Eisai R & D Management Co., Ltd. Therapeutic agent for liver fibrosis
WO2008010571A1 (fr) 2006-07-21 2008-01-24 Taiho Pharmaceutical Co., Ltd. Composé nucléosidique de 2'cyanopyrimidine
MX2009001003A (es) 2006-07-24 2009-02-06 Taiho Pharmaceutical Co Ltd Derivado de 3'-etinilcitidina.
US8865737B2 (en) * 2006-08-28 2014-10-21 Eisai R&D Management Co., Ltd. Antitumor agent for undifferentiated gastric cancer
US8299046B2 (en) * 2006-11-17 2012-10-30 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
WO2008064133A1 (fr) * 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthèse et activités biologiques de nouveaux composés tricycliques-bis-énones (tbe)
US20100048503A1 (en) 2007-01-19 2010-02-25 Eisai R & D Management Co., Ltd. Composition for treatment of pancreatic cancer
AU2008211952B2 (en) * 2007-01-29 2012-07-19 Eisai R & D Management Co., Ltd. Composition for treatment of undifferentiated-type of gastric cancer
WO2008124691A1 (fr) * 2007-04-05 2008-10-16 Threshold Pharmaceuticals, Inc. Traitement combiné au glufosfamide
US20090048205A1 (en) * 2007-08-15 2009-02-19 Colin Meyer Combination therapy with synthetic triterpenoids and gemcitabine
JO2778B1 (en) 2007-10-16 2014-03-15 ايساي انك Certain vehicles, installations and methods
EP2217247A4 (fr) 2007-11-06 2011-12-28 Pharmaessentia Corp Nouveau procédé de synthèse de nucléosides bêta
CA2705092A1 (fr) * 2007-11-07 2009-05-14 Schering Corporation Nouveaux modulateurs de points de controle du cycle cellulaire et leur utilisation en combinaison avec des inhibiteurs de kinase de point de controle
KR101513326B1 (ko) 2007-11-09 2015-04-17 에자이 알앤드디 매니지먼트 가부시키가이샤 혈관 신생 저해 물질과 항종양성 백금 착물의 병용
WO2009089545A1 (fr) * 2008-01-11 2009-07-16 Reata Pharmaceuticals, Inc. Triterpénoïdes synthétiques et procédés d'utilisation dans le traitement de maladies
KR101506062B1 (ko) * 2008-01-29 2015-03-25 에자이 알앤드디 매니지먼트 가부시키가이샤 혈관 저해 물질과 탁산의 병용
WO2009146216A2 (fr) 2008-04-18 2009-12-03 Reata Pharmaceuticals. Inc. Modulateurs d’inflammation antioxydant : nouveaux dérivés d’acide oléanolique
MX2010011435A (es) 2008-04-18 2011-01-25 Reata Pharmaceuticals Inc Compuestos que incluyen un nucleo farmaceutico antiinflamatorio y sus metodos de uso.
BRPI0911422B8 (pt) 2008-04-18 2021-05-25 Reata Pharmaceuticals Inc compostos moduladores inflamatórios antioxidantes, composição farmacêutica e usos dos mesmos
CA2721838C (fr) 2008-04-18 2017-05-23 Reata Pharmaceuticals, Inc. Modulateurs d'inflammation antioxydants: derives d'acide oleanolique presentant une modification du groupe amino et d'autres modifications en c-17
CN102164941B (zh) 2008-04-18 2015-05-27 里亚塔医药公司 抗氧化剂炎症调节剂:具有饱和c环的齐墩果酸衍生物
EP2859916B1 (fr) 2008-05-22 2017-11-29 Galera Labs, LLC Combinaison d'un agent antimitotique et d'un mimétique de superoxyde-dismutase pour la thérapie antitumorale
JP5758801B2 (ja) * 2008-07-22 2015-08-05 トラスティーズ・オブ・ダートマス・カレッジTrustees of Dartmouth College 単環式シアノエノンおよびその使用方法説明
US20110207680A1 (en) * 2008-08-13 2011-08-25 Curd John G Administration of Glufosfamide For The Treatment of Cancer
ES2628580T3 (es) * 2009-04-06 2017-08-03 Otsuka Pharmaceutical Co., Ltd. Combinación de decitabina con inhibidor de citidina deaminasa y uso del mismo en el tratamiento de cáncer el tratamiento de cáncer
ES2593088T3 (es) * 2009-04-06 2016-12-05 Otsuka Pharmaceutical Co., Ltd. Derivados de (2'-Desoxi-Ribofuranosil)-1,3,4,7-Tetrahidro-(1,3)Diazepin-2-ona para Tratamiento de Cáncer
US8609631B2 (en) 2009-04-06 2013-12-17 Eisai Inc. Compositions and methods for treating cancer
ES2628609T3 (es) * 2009-04-06 2017-08-03 Otsuka Pharmaceutical Co., Ltd. Combinación de fármacos antineoplásicos a base de citidina con inhibidor de citidina deaminasa y uso del mismo en el tratamiento de cáncer
GB0907551D0 (en) 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
EP2473041B1 (fr) 2009-09-04 2018-03-07 Merck Sharp & Dohme Corp. Modulateurs de points de contrôle du cycle cellulaire et leur utilisation en combinaison avec des inhibiteurs de kinase de point de contrôle
CA2790176A1 (fr) 2010-02-18 2011-08-25 Centro Nacional De Investigaciones Oncologicas (Cnio) Composes bicycliques destines a etre utilises en tant qu'inhibiteurs de kinases
ES2575160T3 (es) 2010-03-15 2016-06-24 The Board Of Trustees Of The University Of Illinois Inhibidores de las interacciones que unen la subunidad alfa de la beta integrina-proteína G
WO2011143590A1 (fr) 2010-05-14 2011-11-17 Cornerstone Pharmaceuticals, Inc. Compositions et méthodes de polythérapie utilisant dérivés d'acide lipoïque et agent antiprolifératif
WO2011143593A1 (fr) 2010-05-14 2011-11-17 Cornerstone Pharmaceuticals, Inc. Conjugués de dérivé d'acide lipoïque et d'agent antiprolifératif et leurs utilisations médicales
US8530444B2 (en) * 2010-06-01 2013-09-10 Aposense Ltd. Pharmaceutical compounds
US9192680B2 (en) 2010-06-01 2015-11-24 Aposense Ltd. Pharmaceutical compounds
CA2802644C (fr) 2010-06-25 2017-02-21 Eisai R & D Management Co., Ltd. Agent anticancereux utilisant des composes ayant un effet inhibiteur de kinase en combinaison
WO2012069972A1 (fr) 2010-11-19 2012-05-31 Piramal Life Sciences Limited Combinaison pharmaceutique pour le traitement du cancer du sein
WO2012087943A2 (fr) 2010-12-20 2012-06-28 The Regents Of The University Of Michigan Inhibiteurs de l'interaction de liaison entre le récepteur du facteur de croissance épidermique et la protéine de choc thermique 90
WO2012123889A1 (fr) 2011-03-14 2012-09-20 Piramal Healthcare Limited Combinaison pharmaceutique synergique pour le traitement du cancer du pancréas
CN103635192B (zh) 2011-04-01 2017-07-04 基因泰克公司 Akt抑制剂化合物和化疗剂的组合以及使用方法
CA2828946C (fr) 2011-04-18 2016-06-21 Eisai R&D Management Co., Ltd. Agent therapeutique pour les tumeurs
US9945862B2 (en) 2011-06-03 2018-04-17 Eisai R&D Management Co., Ltd. Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
DK2833905T3 (en) 2012-04-04 2018-07-30 Halozyme Inc Combination therapy with hyaluronidase and a tumor-targeted taxane
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
EP3545968A1 (fr) 2012-06-08 2019-10-02 F. Hoffmann-La Roche AG Sélectivité mutante et combinaisons d'un composé inhibiteur de phosphoinositide kinase 3 et d'agents chimiothérapeutiques pour le traitement du cancer
CN107973856B (zh) 2012-07-04 2021-11-23 弗·哈夫曼-拉罗切有限公司 共价连接的抗原-抗体缀合物
EP2711009A1 (fr) 2012-09-19 2014-03-26 Institut Univ. de Ciència i Tecnologia, S.A. Composés destinés à être utilisés dans le traitement ou la prévention du cancer primitif et métastatique du sein et de la prostate
EP2711007A1 (fr) 2012-09-19 2014-03-26 Institut Univ. de Ciència i Tecnologia, S.A. 4-Aminopyrazolo[3,4-d]pyrimidine destiné à être utilisé dans le traitement ou la prévention du cancer du sein et de la prostate primitif et métastatique
EP2711008A1 (fr) 2012-09-19 2014-03-26 Institut Univ. de Ciència i Tecnologia, S.A. N6,N6-dimethyladenosine destiné à être utilisé dans le traitement ou la prévention du cancer du sein primitif et métastatique
EP2919759A4 (fr) 2012-11-14 2016-07-20 Ohio State Innovation Foundation Matières et procédés utiles pour le traitement du glioblastome
WO2014098176A1 (fr) 2012-12-21 2014-06-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 Forme amorphe de dérivé de quinoline et son procédé de production
KR102204279B1 (ko) 2013-05-14 2021-01-15 에자이 알앤드디 매니지먼트 가부시키가이샤 자궁내막암 대상의 렌바티닙 화합물에 대한 반응성을 예측 및 평가하기 위한 생체표지
EP3151864B1 (fr) 2014-06-09 2020-08-05 Lipomedix Pharmaceuticals Ltd. Traitement combiné comprenant un promédicament liposomal de la mitomycine c et une radiothérapie
WO2015197736A1 (fr) 2014-06-26 2015-12-30 F. Hoffmann-La Roche Ag Anticorps anti-brdu et méthodes d'utilisation
MX2017001980A (es) 2014-08-28 2017-05-04 Eisai R&D Man Co Ltd Derivado de quinolina muy puro y metodo para su produccion.
WO2016078160A1 (fr) * 2014-11-17 2016-05-26 常州方圆制药有限公司 Dérivé de cytidine et application de celui-ci
WO2016123143A1 (fr) 2015-01-26 2016-08-04 The University Of Chicago Lymphocytes t à récepteur d'antigène chimérique (car) reconnaissant le récepteur il 13rα2 spécifique au cancer
US10308719B2 (en) 2015-01-26 2019-06-04 The University Of Chicago IL13Rα2 binding agents and use thereof in cancer treatment
BR112017017428A2 (pt) 2015-02-25 2018-04-03 Eisai R&D Management Co., Ltd. ?método para supressão do amargor de derivado de quinolina?
KR102662228B1 (ko) 2015-03-04 2024-05-02 머크 샤프 앤드 돔 코포레이션 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
JP6757959B2 (ja) 2015-06-16 2020-09-23 株式会社 PRISM BioLab 抗がん剤
CN106317147B (zh) * 2015-07-06 2018-11-27 扬州硒瑞恩生物医药科技有限公司 核苷类化合物及其制备方法
JP2019523778A (ja) 2016-06-29 2019-08-29 イーライ リリー アンド カンパニー 膵癌の治療に使用するための、erk1/2阻害剤化合物と、ゲムシタビン、またはゲムシタビンおよびnab−パクリタキセルとの併用
WO2018094406A1 (fr) 2016-11-21 2018-05-24 Bexion Pharmaceuticals, Inc. Traitements combinés comprenant sapc-dops pour le traitement du cancer du pancréas
US11584733B2 (en) 2017-01-09 2023-02-21 Shuttle Pharmaceuticals, Inc. Selective histone deacetylase inhibitors for the treatment of human disease
WO2018129533A1 (fr) 2017-01-09 2018-07-12 Shuttle Pharmaceuticals, Llc Inhibiteurs sélectifs d'histone déacétylase pour le traitement d'une maladie humaine
EP3664844A1 (fr) 2017-08-07 2020-06-17 Amgen Inc. Traitement du cancer du sein triple négatif ou du cancer colorectal comportant des métastases hépatiques par un anticorps anti-pd-l1 et un virus oncolytique
GB202103867D0 (en) 2017-09-18 2021-05-05 Univ California Claudin6 antibodies and methods of treating cancer
US11407723B2 (en) 2018-01-09 2022-08-09 Shuttle Pharmaceuticals, Inc. Selective histone deacetylase inhibitors for the treatment of human disease
BR112020015745A2 (pt) 2018-02-02 2020-12-08 Maverix Oncology, Inc. Conjugados de fármacos de moléculas pequenas de monofosfato de gemcitabina
WO2019222435A1 (fr) 2018-05-16 2019-11-21 Halozyme, Inc. Procédés de sélection de sujets pour une polythérapie anticancéreuse avec un ph20 soluble conjugué à un polymère
MA53140A (fr) 2018-06-29 2021-05-19 Shanghai Changchengyiyaokeji Company Ltd Promédicaments contenant du phosphore de gemcitabine
WO2020058405A1 (fr) 2018-09-20 2020-03-26 Basilea Pharmaceutica International AG Associations pharmaceutiques destinées à être utilisées dans le traitement du cancer
AU2020207026A1 (en) 2019-01-11 2021-07-29 Lipomedix Pharmaceuticals Ltd. Liposome composition comprising liposomal prodrug of mitomycin C and method of manufacture
EP3941944A4 (fr) 2019-03-20 2022-11-30 The Regents of the University of California Anticorps de claudin-6 bispécifiques
MX2021011330A (es) 2019-03-20 2021-12-10 Univ California Anticuerpos de claudina-6 y conjugados de fármacos.
US20220195059A1 (en) 2019-04-30 2022-06-23 Instituto de Medicina Molecular João Lobo Antunes Rank Pathway Inhibitors in Combination with CDK Inhibitors
EP3980541A1 (fr) 2019-06-04 2022-04-13 Apterna Limited Aptamères d'arn dirigés contre le récepteur de transferrine (tfr)
AU2020303986A1 (en) 2019-06-24 2021-12-09 Amgen Inc. Inhibition of SIRP-gamma for cancer treatment
CN110684062B (zh) * 2019-10-18 2022-12-13 大连大学 一种治疗非小细胞肺癌的药物及其制备方法
GB202019692D0 (en) 2020-12-14 2021-01-27 Apterna Ltd Aptamer-sirna fusions

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE147774C (fr) *
US3705147A (en) * 1969-08-22 1972-12-05 Univ Utah 3-deazapyrimidine nucleosides and method of preparation thereof
US3870700A (en) * 1973-05-29 1975-03-11 Miles Lab 2-halogeno-2-deoxy-5-(substituted)uridines
JPS5136467A (en) * 1974-09-20 1976-03-27 Tanabe Seiyaku Co 11 beetaa dd2** harogeno 2** deokishiribofuranoshirurashirujudotai no seiho
DE2628202A1 (de) * 1976-06-23 1977-12-29 Max Planck Gesellschaft Verfahren zur herstellung von 2'-substituierten-d-ribofuranosylpurinderivaten
US4058602A (en) * 1976-08-09 1977-11-15 The United States Of America As Represented By The Department Of Health, Education And Welfare Synthesis, structure, and antitumor activity of 5,6-dihydro-5-azacytidine
US4211773A (en) * 1978-10-02 1980-07-08 Sloan Kettering Institute For Cancer Research 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
ZA859008B (en) * 1984-12-04 1987-07-29 Lilly Co Eli The treatment of tumors in mammals
CA1295998C (fr) * 1985-07-29 1992-02-18 Sai P. Sunkara Nucleosides et leur utilisation en tant qu'agents antineoplasiques
US4914028A (en) * 1988-02-10 1990-04-03 Eli Lilly And Company Method of preparing beta-2',2'-difluoronucleosides
US4983724A (en) * 1988-02-16 1991-01-08 Eli Lilly And Company Inversion of 2,2-difluororibose to a 2,2-difluoroxylose and intermediates therefor
JPH0232093A (ja) * 1988-06-08 1990-02-01 Merrell Dow Pharmaceut Inc 抗レトロウィルスジフルオロ化ヌクレオシド類

Also Published As

Publication number Publication date
JPH0637394B2 (ja) 1994-05-18
DK162965C (da) 1992-06-01
CN1020194C (zh) 1993-03-31
CA1264738A (fr) 1990-01-23
DK549685A (da) 1986-06-05
KR890003439B1 (ko) 1989-09-21
ES549547A0 (es) 1987-08-01
JPS61148193A (ja) 1986-07-05
IE60328B1 (en) 1994-06-29
GR852858B (fr) 1986-03-28
ATE92499T1 (de) 1993-08-15
NZ214364A (en) 1988-11-29
PT81559A (en) 1985-12-01
DK162965B (da) 1992-01-06
EP0184365A2 (fr) 1986-06-11
KR890003426B1 (ko) 1989-09-20
CN85109409A (zh) 1986-08-27
KR860004920A (ko) 1986-07-16
ES8801546A1 (es) 1987-08-01
DE3587500T2 (de) 1993-12-16
EG17765A (en) 1990-08-30
HUT39188A (en) 1986-08-28
PT81559B (pt) 1988-03-03
US5464826A (en) 1995-11-07
EP0184365B1 (fr) 1993-08-04
CY1806A (en) 1995-09-08
DK549685D0 (da) 1985-11-28
IL77133A (en) 1991-01-31
DE3587500D1 (de) 1993-09-09
AU5055585A (en) 1986-06-12
HK113693A (en) 1993-10-29
HU194273B (en) 1988-01-28
AU581269B2 (en) 1989-02-16
IE853038L (en) 1986-06-04
EP0184365A3 (en) 1988-01-27

Similar Documents

Publication Publication Date Title
PH23172A (en) Improvements in the treatment of tumors in mammals
EP0151910A3 (en) Radiotherapy treatment table
GR74609B (fr)
EP0189680A3 (en) Stabilizing power source apparatus
EP0236684A3 (en) Galanthamine or analogues thereof for treating alzheimer's disease
GB2081695B (en) Surface treatment for carbon
GB8414113D0 (en) Treating textiles
PH22351A (en) Novel method for the treatment of neoplasms
GB8717338D0 (en) Carbon containing compound treating apparatus
EP0294028A3 (en) Fluoxetine useful for the treatment of diabetes
ZA859008B (en) The treatment of tumors in mammals
GB8720901D0 (en) Treating leather
GB8525981D0 (en) Treating fabric for shrinkage
EP0230910A3 (en) Means for treating textiles
GB8519615D0 (en) Treating leather
GB2185017A (en) Seco-sterol compounds effective in inducing the differentiation of malignant cells
EP0157530A3 (en) Wood treatment
GB2205586B (en) Treating wood
GB9024861D0 (en) Bis-dioxopiperazines for treating liver tumors
DE3371040D1 (en) Air injection bath for balneo therapy or thalasso therapy
JPS5711260A (en) Homogenous dyeing treatment
BG38956A1 (en) Means for treating pneumoenterites on calves
GB8527485D0 (en) Treating wood
GB8405136D0 (en) Wood treatment
GB8410693D0 (en) Wood treatment