DE3856330T2 - Verfahren zur selektiven Isolierung von beta-2'-desoxy-2'2'-difluorocytidin oder seiner Salze - Google Patents
Verfahren zur selektiven Isolierung von beta-2'-desoxy-2'2'-difluorocytidin oder seiner SalzeInfo
- Publication number
- DE3856330T2 DE3856330T2 DE3856330T DE3856330T DE3856330T2 DE 3856330 T2 DE3856330 T2 DE 3856330T2 DE 3856330 T DE3856330 T DE 3856330T DE 3856330 T DE3856330 T DE 3856330T DE 3856330 T2 DE3856330 T2 DE 3856330T2
- Authority
- DE
- Germany
- Prior art keywords
- deoxy
- difluorocytidine
- beta
- salts
- difluoronucleosides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9072587A | 1987-08-28 | 1987-08-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3856330D1 DE3856330D1 (de) | 1999-06-10 |
DE3856330T2 true DE3856330T2 (de) | 1999-09-30 |
Family
ID=22224017
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3856477T Expired - Fee Related DE3856477T2 (de) | 1987-08-28 | 1988-08-22 | Verfahren zur Herstellung von 2'-deoxy-2',2'-difluornukleosiden |
DE3856527T Expired - Lifetime DE3856527T2 (de) | 1987-08-28 | 1988-08-22 | Stereoselektives Verfahren zur Herstellung von geschützten 2',2'-difluorlactonen |
DE3856158T Expired - Lifetime DE3856158T2 (de) | 1987-08-28 | 1988-08-22 | Verfahren zur Herstellung von Zwischenverbindungen verwendbar in der Herstellung von 2',2'-Difluoronucleosiden |
DE3856330T Expired - Lifetime DE3856330T2 (de) | 1987-08-28 | 1988-08-22 | Verfahren zur selektiven Isolierung von beta-2'-desoxy-2'2'-difluorocytidin oder seiner Salze |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3856477T Expired - Fee Related DE3856477T2 (de) | 1987-08-28 | 1988-08-22 | Verfahren zur Herstellung von 2'-deoxy-2',2'-difluornukleosiden |
DE3856527T Expired - Lifetime DE3856527T2 (de) | 1987-08-28 | 1988-08-22 | Stereoselektives Verfahren zur Herstellung von geschützten 2',2'-difluorlactonen |
DE3856158T Expired - Lifetime DE3856158T2 (de) | 1987-08-28 | 1988-08-22 | Verfahren zur Herstellung von Zwischenverbindungen verwendbar in der Herstellung von 2',2'-Difluoronucleosiden |
Country Status (11)
Country | Link |
---|---|
EP (4) | EP0306190B1 (de) |
JP (5) | JP2738540B2 (de) |
KR (1) | KR970002659B1 (de) |
AT (4) | ATE217009T1 (de) |
CA (1) | CA1324128C (de) |
DE (4) | DE3856477T2 (de) |
ES (4) | ES2157289T3 (de) |
GR (1) | GR3026611T3 (de) |
HU (3) | HU206886B (de) |
IE (1) | IE81131B1 (de) |
IL (1) | IL87517A (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2012129A1 (en) * | 1989-03-20 | 1990-09-20 | Ramakrishnan Nagarajan | Recovery of difluoro sugar |
US5401861A (en) * | 1992-06-22 | 1995-03-28 | Eli Lilly And Company | Low temperature process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates |
UA41261C2 (uk) * | 1992-06-22 | 2001-09-17 | Елі Ліллі Енд Компані | Спосіб одержання збагачених бета-аномером нуклеозидів |
US5252756A (en) * | 1992-06-22 | 1993-10-12 | Eli Lilly And Company | Process for preparing beta-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl-arylsulfonates |
US5256798A (en) * | 1992-06-22 | 1993-10-26 | Eli Lilly And Company | Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates |
US5256797A (en) * | 1992-06-22 | 1993-10-26 | Eli Lilly And Company | Process for separating 2-deoxy-2,2-difluoro-D-ribofuranosyl alkylsulfonate anomers |
YU43193A (sh) * | 1992-06-22 | 1997-01-08 | Eli Lilly And Company | 2'-deoksi-2',2'-difluoro(4-supstituisani)pirimidinski nukleozidi antivirusnog i antikancerogenog dejstva i međuproizvodi |
US5559222A (en) * | 1995-02-03 | 1996-09-24 | Eli Lilly And Company | Preparation of 1-(2'-deoxy-2',2'-difluoro-D-ribo-pentofuranosyl)-cytosine from 2-deoxy-2,2-difluoro-β-D-ribo-pentopyranose |
WO1997021719A1 (en) | 1995-12-13 | 1997-06-19 | Eli Lilly And Company | α, α-DIFLUORO-β-HYDROXY THIOL ESTERS AND THEIR SYNTHESIS |
KR100578616B1 (ko) * | 2004-07-23 | 2006-05-10 | 한미약품 주식회사 | D-에리트로-2,2-다이플루오로-2-데옥시-1-옥소라이보스화합물의 제조방법 |
EP1940859A1 (de) * | 2005-10-28 | 2008-07-09 | Arch Pharmalabs Limited | Verbessertes verfahren zur zubereitung von gemcitabinhydrochlorid |
BRPI0619928A2 (pt) * | 2005-12-14 | 2011-10-25 | Dong A Pharm Co Ltd | processo de produção de 2', 2'-difluornucleosìdeo e intermediário |
KR100741310B1 (ko) * | 2006-08-01 | 2007-08-01 | (주) 유일팜테크 | 젬시타빈의 합성에 유용한 신규한나프탈렌-2-카르복실레이트 유도체와 그의 제조방법 |
WO2008117955A1 (en) * | 2007-03-23 | 2008-10-02 | Dongwoo Syntech Co., Ltd. | Process for preparing of 2'-deoxy-2'2'-difluorocytidine |
CN102216314A (zh) * | 2008-06-12 | 2011-10-12 | 台湾神隆股份有限公司 | 吉西他滨碱的结晶多晶型物 |
GB0812895D0 (en) * | 2008-07-15 | 2008-08-20 | Glycom As | Crystalline carbohydrate derivative |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4526988A (en) * | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
DE3587500T2 (de) * | 1984-12-04 | 1993-12-16 | Lilly Co Eli | Tumorbehandlung bei Säugetieren. |
CA1295998C (en) * | 1985-07-29 | 1992-02-18 | Sai P. Sunkara | Nucleosides and their use as antineoplastic agents |
-
1988
- 1988-08-22 CA CA000575329A patent/CA1324128C/en not_active Expired - Lifetime
- 1988-08-22 ES ES95201846T patent/ES2157289T3/es not_active Expired - Lifetime
- 1988-08-22 EP EP88307750A patent/EP0306190B1/de not_active Expired - Lifetime
- 1988-08-22 EP EP95201845A patent/EP0688782B1/de not_active Expired - Lifetime
- 1988-08-22 ES ES95201845T patent/ES2176279T3/es not_active Expired - Lifetime
- 1988-08-22 DE DE3856477T patent/DE3856477T2/de not_active Expired - Fee Related
- 1988-08-22 AT AT95201845T patent/ATE217009T1/de not_active IP Right Cessation
- 1988-08-22 DE DE3856527T patent/DE3856527T2/de not_active Expired - Lifetime
- 1988-08-22 IL IL87517A patent/IL87517A/xx not_active IP Right Cessation
- 1988-08-22 AT AT88307750T patent/ATE164847T1/de not_active IP Right Cessation
- 1988-08-22 ES ES94202041T patent/ES2131152T3/es not_active Expired - Lifetime
- 1988-08-22 EP EP95201846A patent/EP0688783B1/de not_active Expired - Lifetime
- 1988-08-22 AT AT94202041T patent/ATE179713T1/de not_active IP Right Cessation
- 1988-08-22 DE DE3856158T patent/DE3856158T2/de not_active Expired - Lifetime
- 1988-08-22 ES ES88307750T patent/ES2113845T3/es not_active Expired - Lifetime
- 1988-08-22 DE DE3856330T patent/DE3856330T2/de not_active Expired - Lifetime
- 1988-08-22 AT AT95201846T patent/ATE202113T1/de not_active IP Right Cessation
- 1988-08-22 EP EP94202041A patent/EP0630905B1/de not_active Expired - Lifetime
- 1988-08-26 IE IE260888A patent/IE81131B1/en not_active IP Right Cessation
- 1988-08-26 HU HU906268A patent/HU206886B/hu unknown
- 1988-08-26 JP JP63213482A patent/JP2738540B2/ja not_active Expired - Lifetime
- 1988-08-26 HU HU884471A patent/HU202249B/hu unknown
- 1988-08-27 KR KR1019880010908A patent/KR970002659B1/ko not_active IP Right Cessation
-
1992
- 1992-05-27 HU HU9201768A patent/HU9201768D0/hu unknown
-
1997
- 1997-08-25 JP JP9227948A patent/JP2810034B2/ja not_active Expired - Lifetime
- 1997-08-25 JP JP9227946A patent/JP2777359B2/ja not_active Expired - Lifetime
- 1997-08-25 JP JP9227952A patent/JP2899576B2/ja not_active Expired - Lifetime
- 1997-08-25 JP JP9227954A patent/JP2899577B2/ja not_active Expired - Lifetime
-
1998
- 1998-04-10 GR GR980400807T patent/GR3026611T3/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3856330D1 (de) | Verfahren zur selektiven Isolierung von beta-2'-desoxy-2'2'-difluorocytidin oder seiner Salze | |
ATE126223T1 (de) | Verfahren zur herstellung von ascorbinsäure. | |
DE3680800D1 (de) | Verfahren zur herstellung von (6r)-tetrahydro-l-biopterin. | |
MY102581A (en) | Process for production of avermectins and cultures therefor | |
EP0187680A3 (en) | Process for producing organic acids by use of microorganisms | |
DE3586017D1 (de) | Stabiles glukose-isomerase-konzentrat und verfahren zu dessen herstellung. | |
DE69839306D1 (de) | Verfahren zur herstellung und reinigung von 9-nitro-20-camptothecin | |
DE3784988D1 (de) | Methode fuer selektiven zuwachs des anteils der gewoenlichen hauptkomponente des antibiotischen komplexes a/16686. | |
DE3682247D1 (de) | Vorrichtung und verfahren zur herstellung von gelierten perlen von mikrobischen zellen oder enzymen. | |
BR8801895A (pt) | Processo de producao de uma composicao de polidiorganossiloxana,composicao polidiorganossilaxana e processo para preparar uma espuma | |
DE3587651D1 (de) | Verfahren zur Verbesserung des Wachstums bestimmter Pflanzen. | |
DE3785266D1 (de) | Stamm zur massenproduktion von epsilon-poly-l-lysin, methode, um diesen stamm zu gebrauchen, und methode zur herstellung von epsilon-poly-l-lysin. | |
DE3782169D1 (de) | Verfahren zur herstellung von antibiotica 10381b. | |
ATE89604T1 (de) | Verfahren zur herstellung von aglykonen von avermectin und sie enthaltende kulturen. | |
ATE118551T1 (de) | Verfahren zur herstellung von s-2,2-r1,r2-1,3- dioxolan-4-methanol. | |
DE3880072D1 (de) | N-phenyl-2,2,6,6-tetrahalogencyclohexanimin und verfahren zur herstellung von derivaten des 2,2,6,6-tetrahalogencyclohexanimins und von derivaten des 2,6-dihalogenanilins. | |
DE69225610T2 (de) | Verfahren zur herstellung von avermectin und kulturen dafür | |
ATE58140T1 (de) | Verfahren zur herstellung eines lactons. | |
DE3884922T2 (de) | Verfahren zur Herstellung von thermostabilen alpha-Amylasen durch Kultivierung von überproduzierenden Mikroorganismen. | |
JPS5284024A (en) | Method of producing animal or plant sample or decoration | |
KR920002773A (ko) | 고정화 균주를 이용한 인산화된 아미노클리코시드 항생물질의 제조방법 | |
IT1209488B (it) | Destrutturizzati. procedimento per la produzione di substrati cellulosici |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |