ATE164847T1 - Verfahren zur herstellung von zwischenverbindungen verwendbar in der herstellung von 2',2'-difluoronucleosiden - Google Patents

Verfahren zur herstellung von zwischenverbindungen verwendbar in der herstellung von 2',2'-difluoronucleosiden

Info

Publication number
ATE164847T1
ATE164847T1 AT88307750T AT88307750T ATE164847T1 AT E164847 T1 ATE164847 T1 AT E164847T1 AT 88307750 T AT88307750 T AT 88307750T AT 88307750 T AT88307750 T AT 88307750T AT E164847 T1 ATE164847 T1 AT E164847T1
Authority
AT
Austria
Prior art keywords
difluoronucleosides
production
intermediate compounds
compounds usable
producing intermediate
Prior art date
Application number
AT88307750T
Other languages
English (en)
Inventor
Ta-Sen Chou
Perry Clark Heath
Lawrence Edward Patterson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE164847T1 publication Critical patent/ATE164847T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Epoxy Compounds (AREA)
AT88307750T 1987-08-28 1988-08-22 Verfahren zur herstellung von zwischenverbindungen verwendbar in der herstellung von 2',2'-difluoronucleosiden ATE164847T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9072587A 1987-08-28 1987-08-28

Publications (1)

Publication Number Publication Date
ATE164847T1 true ATE164847T1 (de) 1998-04-15

Family

ID=22224017

Family Applications (4)

Application Number Title Priority Date Filing Date
AT95201846T ATE202113T1 (de) 1987-08-28 1988-08-22 Verfahren zur herstellung von 2'-deoxy-2',2'- difluornukleosiden
AT94202041T ATE179713T1 (de) 1987-08-28 1988-08-22 Verfahren zur selektiven isolierung von beta-2'- desoxy-2'2'-difluorocytidin oder seiner salze
AT88307750T ATE164847T1 (de) 1987-08-28 1988-08-22 Verfahren zur herstellung von zwischenverbindungen verwendbar in der herstellung von 2',2'-difluoronucleosiden
AT95201845T ATE217009T1 (de) 1987-08-28 1988-08-22 Stereoselektives verfahren zur herstellung von geschützten 2',2'-difluorlactonen

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT95201846T ATE202113T1 (de) 1987-08-28 1988-08-22 Verfahren zur herstellung von 2'-deoxy-2',2'- difluornukleosiden
AT94202041T ATE179713T1 (de) 1987-08-28 1988-08-22 Verfahren zur selektiven isolierung von beta-2'- desoxy-2'2'-difluorocytidin oder seiner salze

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT95201845T ATE217009T1 (de) 1987-08-28 1988-08-22 Stereoselektives verfahren zur herstellung von geschützten 2',2'-difluorlactonen

Country Status (11)

Country Link
EP (4) EP0630905B1 (de)
JP (5) JP2738540B2 (de)
KR (1) KR970002659B1 (de)
AT (4) ATE202113T1 (de)
CA (1) CA1324128C (de)
DE (4) DE3856477T2 (de)
ES (4) ES2131152T3 (de)
GR (1) GR3026611T3 (de)
HU (3) HU206886B (de)
IE (1) IE81131B1 (de)
IL (1) IL87517A (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2012129A1 (en) * 1989-03-20 1990-09-20 Ramakrishnan Nagarajan Recovery of difluoro sugar
US5401861A (en) * 1992-06-22 1995-03-28 Eli Lilly And Company Low temperature process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
YU43193A (sh) * 1992-06-22 1997-01-08 Eli Lilly And Company 2'-deoksi-2',2'-difluoro(4-supstituisani)pirimidinski nukleozidi antivirusnog i antikancerogenog dejstva i međuproizvodi
US5256798A (en) * 1992-06-22 1993-10-26 Eli Lilly And Company Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
UA41261C2 (uk) * 1992-06-22 2001-09-17 Елі Ліллі Енд Компані Спосіб одержання збагачених бета-аномером нуклеозидів
US5252756A (en) * 1992-06-22 1993-10-12 Eli Lilly And Company Process for preparing beta-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl-arylsulfonates
US5256797A (en) * 1992-06-22 1993-10-26 Eli Lilly And Company Process for separating 2-deoxy-2,2-difluoro-D-ribofuranosyl alkylsulfonate anomers
US5559222A (en) * 1995-02-03 1996-09-24 Eli Lilly And Company Preparation of 1-(2'-deoxy-2',2'-difluoro-D-ribo-pentofuranosyl)-cytosine from 2-deoxy-2,2-difluoro-β-D-ribo-pentopyranose
JP2000501738A (ja) 1995-12-13 2000-02-15 イーライ・リリー・アンド・カンパニー α，α―ジフルオロ―β―ヒドロキシチオールエステル及びその合成
KR100578616B1 (ko) * 2004-07-23 2006-05-10 한미약품 주식회사 Ｄ-에리트로-2,2-다이플루오로-2-데옥시-1-옥소라이보스화합물의 제조방법
WO2007049294A1 (en) * 2005-10-28 2007-05-03 Arch Pharmalabs Limited An improved process for preparation of gemcitabine hydrochloride.
RU2008127984A (ru) * 2005-12-14 2010-01-20 Лонг-А Фарм.Ко., Лтд. (Kr) Способ получения 2,2,-дифторнуклеозида и его промежуточных соединений
KR100741310B1 (ko) * 2006-08-01 2007-08-01 (주) 유일팜테크 젬시타빈의 합성에 유용한 신규한나프탈렌-2-카르복실레이트 유도체와 그의 제조방법
US7994310B2 (en) * 2007-03-23 2011-08-09 Dongwoo Syntech Co., Ltd. Process for preparing 2′-deoxy-2′, 2′-difluorocytidine
CN102216314A (zh) * 2008-06-12 2011-10-12 台湾神隆股份有限公司 吉西他滨碱的结晶多晶型物
GB0812895D0 (en) * 2008-07-15 2008-08-20 Glycom As Crystalline carbohydrate derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
IL77133A (en) * 1984-12-04 1991-01-31 Lilly Co Eli Antineoplastic pharmaceutical compositions containing pentofuranoside derivatives,some new such compounds and their preparation
CA1295998C (en) * 1985-07-29 1992-02-18 Sai P. Sunkara Nucleosides and their use as antineoplastic agents

Also Published As

Publication number Publication date
IL87517A0 (en) 1989-01-31
IE81131B1 (en) 2000-03-22
EP0306190A2 (de) 1989-03-08
DE3856477T2 (de) 2001-11-08
JPS6471894A (en) 1989-03-16
DE3856158T2 (de) 1998-08-20
ES2131152T3 (es) 1999-07-16
KR890003794A (ko) 1989-04-18
CA1324128C (en) 1993-11-09
EP0688783A1 (de) 1995-12-27
GR3026611T3 (en) 1998-07-31
KR970002659B1 (ko) 1997-03-07
ATE179713T1 (de) 1999-05-15
JPH1072457A (ja) 1998-03-17
EP0306190A3 (de) 1991-11-21
EP0630905B1 (de) 1999-05-06
HU906268D0 (en) 1991-03-28
HUT47590A (en) 1989-03-28
EP0688782B1 (de) 2002-05-02
DE3856158D1 (de) 1998-05-14
DE3856527T2 (de) 2002-10-31
ATE217009T1 (de) 2002-05-15
JPH1072483A (ja) 1998-03-17
EP0306190B1 (de) 1998-04-08
JP2899577B2 (ja) 1999-06-02
EP0630905A1 (de) 1994-12-28
ES2176279T3 (es) 2002-12-01
IL87517A (en) 1993-05-13
DE3856527D1 (de) 2002-06-06
IE882608L (en) 1989-02-28
JPH1072484A (ja) 1998-03-17
ES2157289T3 (es) 2001-08-16
JP2810034B2 (ja) 1998-10-15
DE3856330T2 (de) 1999-09-30
JP2899576B2 (ja) 1999-06-02
HU9201768D0 (en) 1992-08-28
JPH1081696A (ja) 1998-03-31
DE3856477D1 (de) 2001-07-19
EP0688782A1 (de) 1995-12-27
HU206886B (en) 1993-01-28
ATE202113T1 (de) 2001-06-15
DE3856330D1 (de) 1999-06-10
JP2777359B2 (ja) 1998-07-16
HU202249B (en) 1991-02-28
ES2113845T3 (es) 1998-05-16
JP2738540B2 (ja) 1998-04-08
EP0688783B1 (de) 2001-06-13

Similar Documents

Publication Publication Date Title
ATE164847T1 (de) Verfahren zur herstellung von zwischenverbindungen verwendbar in der herstellung von 2',2'-difluoronucleosiden
AT369017B (de) Verfahren zur herstellung von neuen derivaten der hydroxycarbonylphosphonsaeure, sowie von deren salzen und optischen antipoden
ATE126223T1 (de) Verfahren zur herstellung von ascorbinsäure.
DE3883408D1 (de) Verfahren zur Herstellung von Avermectinen und die verwendeten Kulturen.
DE3586017D1 (de) Stabiles glukose-isomerase-konzentrat und verfahren zu dessen herstellung.
ATE49193T1 (de) Verfahren zur herstellung von (+)s-2-hydroxy-2methyl-hexans|ure.
DE3784988D1 (de) Methode fuer selektiven zuwachs des anteils der gewoenlichen hauptkomponente des antibiotischen komplexes a/16686.
DE3767993D1 (de) Verfahren zur herstellung von thienylaethylaminen, und mittels des verfahrens hergestellte dithienylaethylamine.
DE3581994D1 (de) Verfahren zur herstellung der stereoisomeren von 1-amino-alkylphosphonsaeuren oder 1-amino-alkylphosphinsaeuren.
ATE150003T1 (de) Verfahren zur herstellung von l-(-)-carnitin aus abfallprodukten mit entgegengesetzter konfiguration
DE3855002D1 (de) Verfahren zur Herstellung von Dodecahydro-3a,6,6,9a-tetramethylnaphto(2,1-b)furan
DE3785266T2 (de) Stamm zur massenproduktion von epsilon-poly-l-lysin, methode, um diesen stamm zu gebrauchen, und methode zur herstellung von epsilon-poly-l-lysin.
DE3883466T2 (de) Verfahren zur Herstellung kristalliner (Metallo)silikate.
HUT49892A (en) Process for production of new organic compositions
ATA739479A (de) Verfahren zur herstellung von neuen beta-lacton- derivaten der 2-hydroxycyclopentancarbonsaeure
ATE107631T1 (de) Verfahren zur herstellung von indolinon-2- derivaten.
ATE133409T1 (de) Verfahren zur herstellung von 2-oxindol-1- carboxamiden
ATE118551T1 (de) Verfahren zur herstellung von s-2,2-r1,r2-1,3- dioxolan-4-methanol.
ATA102287A (de) Verfahren zur herstellung von neuen 8- bzw. 1,8- substituierten ergolenderivaten
DE3583794D1 (de) Verfahren zur herstellung von bestaendigen pharmazeutischen zusammensetzungen von prostaglandin-e-derivaten und/oder ihren 15r-formen.
ATE58140T1 (de) Verfahren zur herstellung eines lactons.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time