PH22377A - 5-aryl-2,4-diakyl-3h-1,2,4-triazole-3-thiones and their use as anti-depressant - Google Patents

5-aryl-2,4-diakyl-3h-1,2,4-triazole-3-thiones and their use as anti-depressant

Info

Publication number
PH22377A
PH22377A PH34414A PH34414A PH22377A PH 22377 A PH22377 A PH 22377A PH 34414 A PH34414 A PH 34414A PH 34414 A PH34414 A PH 34414A PH 22377 A PH22377 A PH 22377A
Authority
PH
Philippines
Prior art keywords
diakyl
thiones
depressant
triazole
aryl
Prior art date
Application number
PH34414A
Other languages
English (en)
Inventor
John M Kane
Francis P Miller
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of PH22377A publication Critical patent/PH22377A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PH34414A 1985-10-29 1986-10-24 5-aryl-2,4-diakyl-3h-1,2,4-triazole-3-thiones and their use as anti-depressant PH22377A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79235985A 1985-10-29 1985-10-29
US80761385A 1985-12-11 1985-12-11

Publications (1)

Publication Number Publication Date
PH22377A true PH22377A (en) 1988-08-12

Family

ID=27121269

Family Applications (2)

Application Number Title Priority Date Filing Date
PH34414A PH22377A (en) 1985-10-29 1986-10-24 5-aryl-2,4-diakyl-3h-1,2,4-triazole-3-thiones and their use as anti-depressant
PH35910A PH23275A (en) 1985-10-29 1987-10-08 5-aryl-2,4-diakyl-3h-1,2,4-triazole-3-thiones and their use as anti-depressant

Family Applications After (1)

Application Number Title Priority Date Filing Date
PH35910A PH23275A (en) 1985-10-29 1987-10-08 5-aryl-2,4-diakyl-3h-1,2,4-triazole-3-thiones and their use as anti-depressant

Country Status (19)

Country Link
EP (1) EP0221485B1 (no)
JP (1) JPH07116162B2 (no)
KR (1) KR900003879B1 (no)
CN (1) CN1014993B (no)
AR (1) AR243171A1 (no)
AU (1) AU587646B2 (no)
CA (2) CA1284997C (no)
DE (1) DE3676632D1 (no)
DK (1) DK164785C (no)
ES (1) ES2031449T3 (no)
FI (1) FI89047C (no)
GR (1) GR3001246T3 (no)
HU (1) HU196191B (no)
IE (1) IE58969B1 (no)
IL (1) IL80434A (no)
NO (1) NO165542C (no)
NZ (1) NZ218087A (no)
PH (2) PH22377A (no)
PT (1) PT83636B (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR243169A1 (es) * 1985-10-29 1993-07-30 Merrell Pharma Inc Procedimiento para preparar 5-naftil-2,4-dialquil-3h-1,2,4-triazol-3-tionas.
JP2542880B2 (ja) * 1986-12-19 1996-10-09 メレルダウファーマスーティカルズ インコーポレーテッド ５−アリ―ル−３ｈ−１，２，４，−トリアゾ―ル−３−オン類の抗痙攣剤としての用途
JP2593084B2 (ja) * 1986-12-19 1997-03-19 メレルダウファーマスーティカルズ インコーポレーテッド ５−アリールー３ｈ−１，２，４−トリアゾールー３−オン類の神経変性障害の処置への用途
EP0280867A1 (en) * 1987-01-27 1988-09-07 Merrell Dow Pharmaceuticals Inc. Process for the preparation of 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones
US4847276A (en) * 1988-09-06 1989-07-11 Merrell Dow Pharmaceuticals Inc. Treatment of thromobocytosis with 5-(4-chlorophenyl)-2,4-diemthyl-3H-1,2,4-triazole-3-thione
CN1046273C (zh) * 1993-10-29 1999-11-10 默里尔药物公司 用作记忆增强剂的3－芳基－4－烷基及4,5－二烷基－4h－1,2,4－三唑
AU700620B2 (en) * 1994-07-07 1999-01-07 Merrell Pharmaceuticals Inc. Process for the preparation of 5-aryl-2,4-dialkyl-3 h-1,2,4-triazole-3-thiones

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR243169A1 (es) * 1985-10-29 1993-07-30 Merrell Pharma Inc Procedimiento para preparar 5-naftil-2,4-dialquil-3h-1,2,4-triazol-3-tionas.
DK570987A (da) * 1986-12-01 1988-06-02 Hoffmann La Roche Oxadiazol-, thiadiazol- og triazolforbindelser

Also Published As

Publication number Publication date
DK164785B (da) 1992-08-17
CN1014993B (zh) 1991-12-04
HUT45030A (en) 1988-05-30
HU196191B (en) 1988-10-28
DK514886D0 (da) 1986-10-28
PH23275A (en) 1989-06-23
FI89047B (fi) 1993-04-30
NO165542B (no) 1990-11-19
FI864377A (fi) 1987-04-30
NZ218087A (en) 1989-05-29
EP0221485B1 (en) 1990-12-27
KR870004006A (ko) 1987-05-06
JPS62106085A (ja) 1987-05-16
DE3676632D1 (de) 1991-02-07
DK514886A (da) 1987-04-30
IE58969B1 (en) 1993-12-01
DK164785C (da) 1992-12-28
AR243171A1 (es) 1993-07-30
GR3001246T3 (en) 1992-07-30
NO864306L (no) 1987-04-30
NO165542C (no) 1991-02-27
CA1284997C (en) 1991-06-18
AU6438686A (en) 1987-04-30
CA1301655C (en) 1992-05-26
NO864306D0 (no) 1986-10-28
JPH07116162B2 (ja) 1995-12-13
ES2031449T3 (es) 1992-12-16
PT83636B (pt) 1988-10-14
IE862832L (en) 1987-04-29
PT83636A (en) 1986-11-01
AU587646B2 (en) 1989-08-24
CN86106880A (zh) 1987-06-10
FI89047C (fi) 1993-08-10
IL80434A (en) 1991-01-31
IL80434A0 (en) 1987-01-30
KR900003879B1 (ko) 1990-06-04
EP0221485A1 (en) 1987-05-13
FI864377A0 (fi) 1986-10-28

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