PH12021550857A1 - Compounds, compositions, and methods for modulating cdk9 activity - Google Patents

Compounds, compositions, and methods for modulating cdk9 activity

Info

Publication number
PH12021550857A1
PH12021550857A1 PH12021550857A PH12021550857A PH12021550857A1 PH 12021550857 A1 PH12021550857 A1 PH 12021550857A1 PH 12021550857 A PH12021550857 A PH 12021550857A PH 12021550857 A PH12021550857 A PH 12021550857A PH 12021550857 A1 PH12021550857 A1 PH 12021550857A1
Authority
PH
Philippines
Prior art keywords
modulating
compositions
compounds
methods
cdk9 activity
Prior art date
Application number
PH12021550857A
Other languages
English (en)
Inventor
Peter Mikochik
Joseph VACCA
David Freeman
Andrew Tasker
Original Assignee
Kronos Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kronos Bio Inc filed Critical Kronos Bio Inc
Publication of PH12021550857A1 publication Critical patent/PH12021550857A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PH12021550857A 2018-10-30 2021-04-15 Compounds, compositions, and methods for modulating cdk9 activity PH12021550857A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862752635P 2018-10-30 2018-10-30
US201962884993P 2019-08-09 2019-08-09
US201962910058P 2019-10-03 2019-10-03
PCT/US2019/058482 WO2020092314A1 (en) 2018-10-30 2019-10-29 Compounds, compositions, and methods for modulating cdk9 activity

Publications (1)

Publication Number Publication Date
PH12021550857A1 true PH12021550857A1 (en) 2021-12-06

Family

ID=70328627

Family Applications (1)

Application Number Title Priority Date Filing Date
PH12021550857A PH12021550857A1 (en) 2018-10-30 2021-04-15 Compounds, compositions, and methods for modulating cdk9 activity

Country Status (21)

Country Link
US (3) US11155560B2 (https=)
EP (1) EP3873911A4 (https=)
JP (1) JP7385658B2 (https=)
KR (2) KR20250174699A (https=)
CN (1) CN112996790B (https=)
AU (1) AU2019370200B2 (https=)
BR (1) BR112021008176A2 (https=)
CA (1) CA3118472A1 (https=)
CO (1) CO2021005502A2 (https=)
CR (1) CR20210202A (https=)
DO (1) DOP2021000066A (https=)
IL (1) IL282254B2 (https=)
MA (1) MA54092A (https=)
MD (1) MD20210033A2 (https=)
MX (1) MX2021004769A (https=)
MY (1) MY210039A (https=)
PE (1) PE20212196A1 (https=)
PH (1) PH12021550857A1 (https=)
SG (1) SG11202104229WA (https=)
WO (1) WO2020092314A1 (https=)
ZA (1) ZA202102609B (https=)

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EP4282868B1 (en) * 2021-01-22 2026-03-04 Shanghai Haiyan Pharmaceutical Technology Co., Ltd. Substituted pyrazolo[1,5-a]pyrimidine-7-amine derivative, and compositions and medical use thereof
JP2024543136A (ja) * 2021-11-24 2024-11-19 クロノス バイオ インコーポレイテッド （１Ｓ，３Ｓ）－Ｎ１－（５－（ペンタン－３－イル）ピラゾロ［１，５－ａ］ピリミジン－７－イル）シクロペンタン－１，３－ジアミンの多形性形態および塩形態
JP2025527161A (ja) * 2022-07-22 2025-08-20 上海海雁醫藥科技有限公司 置換されたピラゾロ［１，５－ａ］ピリミジン－７－アミン誘導体の薬学的に許容される塩および多形体、ならびにその使用
WO2025153034A1 (zh) * 2024-01-19 2025-07-24 上海海雁医药科技有限公司 一种吡唑并嘧啶衍生物的磷酸盐多晶型物及其应用

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Also Published As

Publication number Publication date
CN112996790A (zh) 2021-06-18
AU2019370200B2 (en) 2024-12-19
ZA202102609B (en) 2023-02-22
AU2019370200A1 (en) 2021-06-10
MA54092A (fr) 2021-09-08
MX2021004769A (es) 2021-08-24
KR20210068597A (ko) 2021-06-09
MD20210033A2 (ro) 2021-10-31
US11155560B2 (en) 2021-10-26
PE20212196A1 (es) 2021-11-16
IL282254A (en) 2021-05-31
KR20250174699A (ko) 2025-12-12
US20200131189A1 (en) 2020-04-30
US20240132506A1 (en) 2024-04-25
US11845754B2 (en) 2023-12-19
CA3118472A1 (en) 2020-05-07
US20220002305A1 (en) 2022-01-06
DOP2021000066A (es) 2021-10-31
JP7385658B2 (ja) 2023-11-22
WO2020092314A1 (en) 2020-05-07
CN112996790B (zh) 2023-11-03
EP3873911A1 (en) 2021-09-08
EP3873911A4 (en) 2022-06-22
IL282254B2 (en) 2025-08-01
JP2022505268A (ja) 2022-01-14
IL282254B1 (en) 2025-04-01
MY210039A (en) 2025-08-22
CO2021005502A2 (es) 2021-09-20
SG11202104229WA (en) 2021-05-28
BR112021008176A2 (pt) 2021-08-03
CR20210202A (es) 2022-02-08

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