PH12020500672A1 - Splicing modulators antibody-drug conjugates - Google Patents

Splicing modulators antibody-drug conjugates

Info

Publication number
PH12020500672A1
PH12020500672A1 PH12020500672A PH12020500672A PH12020500672A1 PH 12020500672 A1 PH12020500672 A1 PH 12020500672A1 PH 12020500672 A PH12020500672 A PH 12020500672A PH 12020500672 A PH12020500672 A PH 12020500672A PH 12020500672 A1 PH12020500672 A1 PH 12020500672A1
Authority
PH
Philippines
Prior art keywords
drug conjugates
antibody
drug
splicing modulators
linker
Prior art date
Application number
PH12020500672A
Other languages
English (en)
Inventor
Ermira Pazolli
Silvia Buonamici
Thiwanka Samarakoon
Sudeep Prajapati
Nathan Fishkin
James Palacino
Michael Seiler
Ping Zhu
Andrew Cook
Peter Smith
Xiang Liu
Shelby Ellery
Dominic Reynolds
Lihua Yu
Zhenhua Wu
Shouyong Peng
Nicholas Calandra
Megan Sheehan
Yonghong Xiao
Original Assignee
Eisai R And D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=66999916&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PH12020500672(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eisai R And D Man Co Ltd filed Critical Eisai R And D Man Co Ltd
Publication of PH12020500672A1 publication Critical patent/PH12020500672A1/en

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    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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