PE48794A1 - Proceso quimico - Google Patents

Proceso quimico

Info

Publication number
PE48794A1
PE48794A1 PE1994238491A PE23849194A PE48794A1 PE 48794 A1 PE48794 A1 PE 48794A1 PE 1994238491 A PE1994238491 A PE 1994238491A PE 23849194 A PE23849194 A PE 23849194A PE 48794 A1 PE48794 A1 PE 48794A1
Authority
PE
Peru
Prior art keywords
chemical process
salt
compound
formula
preparation
Prior art date
Application number
PE1994238491A
Other languages
English (en)
Inventor
Garfield Cecil Tughan
Original Assignee
Glaxo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Spa filed Critical Glaxo Spa
Publication of PE48794A1 publication Critical patent/PE48794A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D477/00Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cephalosporin Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE REFIERE A UN PROCESO PARA LA PREPARACION DEL COMPUESTO ANTIBACTERIANO DE FORMULA I QUE UTILIZA COMO GRUPO PROTECTOR DEL CARBOXILO DE LA ESTRUCTURA AL GRUPO T-BUTIL BENCILO: -CH2-C6H4-C(CH3)3, QUE REEMPLAZA AL ATOMO DE HIDROGENO, FORMANDOSE ASI UN SOLIDO QUE PERMITE UN PASO DE PURIFICACION SIMPLE COMO CRISTALIZACION, EN LUGAR DE FORMARSE UN ACEITE QUE NO ES DESEABLE PARA UN PROCESO DE SINTESIS EN VARIOS PASOS; Y POSTERIOR HIDROLISIS DE ESTE GRUPO PROTECTOR USANDO HIDROGENO Y UN CATALIZADOR METALICO COMO PALADIO EN UN DISOLVENTE COMO ETANOL, ISOPROPANOL, ACETATO DE ETILO, ACETONA; ESTA REACCION SE LLEVA A CABO PREFERIBLEMENTE EN PRESENCIA DE UNA BASE COMO ALQUILAMINA; REFIRIENDOSE A UN COMPUESTO COMO: (4S, 8S, 9R, 10S, 12R)-4-METOXI-10-(1-HIDROXIETIL)-11-OXO-1-AZATRICICLO (7.2.0.0 SUP(3.8)) UNDEC-2-EN-2-CARBOXILATO DE SODIO
PE1994238491A 1993-03-20 1994-03-16 Proceso quimico PE48794A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939305853A GB9305853D0 (en) 1993-03-20 1993-03-20 Chemical compounds

Publications (1)

Publication Number Publication Date
PE48794A1 true PE48794A1 (es) 1995-01-06

Family

ID=10732481

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1994238491A PE48794A1 (es) 1993-03-20 1994-03-16 Proceso quimico

Country Status (31)

Country Link
EP (1) EP0689543B1 (es)
JP (1) JP3477206B2 (es)
KR (1) KR100292568B1 (es)
CN (1) CN1040981C (es)
AT (1) ATE175968T1 (es)
AU (1) AU681133B2 (es)
CA (1) CA2157110A1 (es)
CZ (1) CZ284250B6 (es)
DE (1) DE69416117T2 (es)
DK (1) DK0689543T3 (es)
EC (1) ECSP941053A (es)
ES (1) ES2127922T3 (es)
FI (1) FI109539B (es)
GB (1) GB9305853D0 (es)
GR (1) GR3029881T3 (es)
HR (1) HRP940174B1 (es)
HU (1) HU216842B (es)
IL (1) IL109017A (es)
IS (1) IS1689B (es)
MY (1) MY110697A (es)
NO (1) NO313294B1 (es)
NZ (1) NZ263546A (es)
PE (1) PE48794A1 (es)
PH (1) PH31046A (es)
PL (1) PL175845B1 (es)
RU (1) RU2127735C1 (es)
SG (1) SG52571A1 (es)
SK (1) SK280488B6 (es)
TW (1) TW305843B (es)
WO (1) WO1994021638A1 (es)
ZA (1) ZA941884B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9406074D0 (en) * 1994-03-26 1994-05-18 Glaxo Spa Chemical process
EP2085084A1 (en) * 2008-01-29 2009-08-05 LEK Pharmaceuticals D.D. Use of inhibitor of beta-lactamases and its combination with beta-lactam antibiotics

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4181733A (en) * 1975-11-21 1980-01-01 Merck & Co., Inc. Carboxyl derivatives of thienamycin
CZ285778B6 (cs) * 1989-09-08 1999-11-17 Glaxo S.P.A. Kyselina 10-(1-hydroxyethyl)-11-oxo-1-azatricyklo/7,2,0,03,8/-undec-2en-2-karboxylová a její deriváty, způsob jejich výroby, použití pro výrobu farmaceutických prostředků a farmaceutické prostředky s jejich obsahem

Also Published As

Publication number Publication date
CA2157110A1 (en) 1994-09-29
ATE175968T1 (de) 1999-02-15
JP3477206B2 (ja) 2003-12-10
FI954400A (fi) 1995-09-18
CZ230195A3 (en) 1995-12-13
DE69416117D1 (de) 1999-03-04
HU9502737D0 (en) 1995-11-28
KR100292568B1 (ko) 2001-09-17
IL109017A0 (en) 1994-06-24
PH31046A (en) 1997-12-29
AU6427394A (en) 1994-10-11
MY110697A (en) 1999-01-30
FI109539B (fi) 2002-08-30
CZ284250B6 (cs) 1998-10-14
AU681133B2 (en) 1997-08-21
PL175845B1 (pl) 1999-02-26
HU216842B (hu) 1999-09-28
CN1040981C (zh) 1998-12-02
PL310621A1 (en) 1995-12-27
IL109017A (en) 1998-06-15
HRP940174A2 (en) 1996-08-31
IS1689B (is) 1998-04-20
WO1994021638A1 (en) 1994-09-29
SK280488B6 (sk) 2000-02-14
NO953698D0 (no) 1995-09-19
EP0689543A1 (en) 1996-01-03
SG52571A1 (en) 1998-09-28
FI954400A0 (fi) 1995-09-18
DE69416117T2 (de) 1999-06-24
GR3029881T3 (en) 1999-07-30
TW305843B (es) 1997-05-21
EP0689543B1 (en) 1999-01-20
CN1119865A (zh) 1996-04-03
GB9305853D0 (en) 1993-05-05
RU2127735C1 (ru) 1999-03-20
NO953698L (no) 1995-09-19
ZA941884B (en) 1994-12-15
SK115995A3 (en) 1996-01-10
NZ263546A (en) 1997-03-24
JPH08507777A (ja) 1996-08-20
IS4139A (is) 1994-09-21
DK0689543T3 (da) 1999-09-13
HRP940174B1 (en) 2000-10-31
ES2127922T3 (es) 1999-05-01
NO313294B1 (no) 2002-09-09
HUT73487A (en) 1996-08-28
ECSP941053A (es) 1994-09-16

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed