PE45095A1 - Nuevos compuestos heterociclicos - Google Patents

Nuevos compuestos heterociclicos

Info

Publication number
PE45095A1
PE45095A1 PE1995258527A PE25852795A PE45095A1 PE 45095 A1 PE45095 A1 PE 45095A1 PE 1995258527 A PE1995258527 A PE 1995258527A PE 25852795 A PE25852795 A PE 25852795A PE 45095 A1 PE45095 A1 PE 45095A1
Authority
PE
Peru
Prior art keywords
hydrogen
cyclic compounds
hetero cyclic
ch2ch2ch2
alkyl
Prior art date
Application number
PE1995258527A
Other languages
English (en)
Spanish (es)
Inventor
Uffe Bang Olsen
Ursula Sonnewald
Knud Erik Andersen
Henrik Sune Andersen
Hans Petersen
Frederick Christian Gronvald
Tine Krogh Orgensen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of PE45095A1 publication Critical patent/PE45095A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
PE1995258527A 1994-01-04 1995-01-04 Nuevos compuestos heterociclicos PE45095A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK1994 1994-01-04
DK129094 1994-11-09

Publications (1)

Publication Number Publication Date
PE45095A1 true PE45095A1 (es) 1995-12-18

Family

ID=26063135

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1995258527A PE45095A1 (es) 1994-01-04 1995-01-04 Nuevos compuestos heterociclicos

Country Status (31)

Country Link
US (8) US5595989A (enExample)
EP (1) EP0738262B1 (enExample)
JP (1) JP2944221B2 (enExample)
KR (1) KR100329450B1 (enExample)
CN (1) CN1083431C (enExample)
AT (1) ATE191909T1 (enExample)
AU (1) AU691858B2 (enExample)
BG (1) BG100692A (enExample)
BR (1) BR9506452A (enExample)
CA (1) CA2180238A1 (enExample)
CZ (1) CZ286109B6 (enExample)
DE (1) DE69516394T2 (enExample)
DK (1) DK0738262T3 (enExample)
ES (1) ES2147837T3 (enExample)
FI (1) FI114025B (enExample)
GR (1) GR3033967T3 (enExample)
HU (1) HUT75878A (enExample)
IL (1) IL112222A (enExample)
MY (1) MY113463A (enExample)
NO (1) NO306295B1 (enExample)
NZ (1) NZ277763A (enExample)
PE (1) PE45095A1 (enExample)
PL (1) PL180209B1 (enExample)
PT (1) PT738262E (enExample)
RU (1) RU2167152C2 (enExample)
SG (1) SG50602A1 (enExample)
SI (1) SI9520023A (enExample)
SK (1) SK88196A3 (enExample)
TW (1) TW300887B (enExample)
UA (1) UA47396C2 (enExample)
WO (1) WO1995018793A1 (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6239148B1 (en) 1994-01-04 2001-05-29 Novo Nordisk A/S N-substituted azaheterocyclic carboxylic acids and esters thereof
MY113463A (en) * 1994-01-04 2002-03-30 Novo Nordisk As Novel heterocyclic compounds
US6110913A (en) * 1994-01-04 2000-08-29 Novo Nordisk A/S N-substituted azaheterocyclic carboxylic acids and esters thereof
US5698551A (en) * 1995-04-07 1997-12-16 Novo Nordisk A/S Heterocyclic compounds
US5952352A (en) * 1995-04-07 1999-09-14 Novo Nordisk A/S Heterocyclic compounds
US5962449A (en) 1995-04-07 1999-10-05 Novo Nordisk A/S Tricyclic compounds in treating hyperalgesic conditions and NIDDM
US5716949A (en) * 1995-04-07 1998-02-10 Novo Nordisk A/S Heterocyclic compounds
UA54385C2 (uk) * 1995-04-07 2003-03-17 Ново Нордіск А/С N-заміщені азагетероциклічні карбонові кислоти та їх ефіри, спосіб їх одержання, фармацевтична композиція та спосіб лікування
IL124557A0 (en) * 1995-12-15 1998-12-06 Novo Nordisk As Compositions for reducing blood glucose and/or inhibiting the activity of cgrp
US6323206B1 (en) 1996-07-12 2001-11-27 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
ZA978792B (en) * 1996-10-04 1998-04-06 Novo Nordisk As N-substituted azaheterocyclic compounds.
JP2001501629A (ja) 1996-10-04 2001-02-06 ノボ ノルディスク アクティーゼルスカブ N―置換アザ複素環式化合物
EP0934312B1 (en) * 1996-10-04 2003-03-19 Novo Nordisk A/S 1,4-disubstituted piperazines
US6040318A (en) * 1997-06-25 2000-03-21 Novo Nordisk A/S Tricycle substituted with azaheterocyclic carboxylic acids
CA2307820C (en) 1997-10-27 2007-04-24 Dr. Reddy's Research Foundation Novel tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them
AU2331999A (en) 1998-01-21 1999-08-09 Kyowa Hakko Kogyo Co. Ltd. Chemokine receptor antagonists and methods of use therefor
WO1999037619A1 (en) * 1998-01-21 1999-07-29 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6509346B2 (en) 1998-01-21 2003-01-21 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6613905B1 (en) 1998-01-21 2003-09-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
ES2137136B1 (es) * 1998-05-18 2000-07-01 Esteve Labor Dr Empleo de derivados de aril (o heteroaril) azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion neurogenica.
US7271176B2 (en) * 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
US6468996B1 (en) * 1998-10-21 2002-10-22 Novo Nordisk A/S Substituted hetero-polycyclic compounds as PPARα and PPARγ activators
AU1649700A (en) * 1998-12-22 2000-07-12 Novo Nordisk A/S Novel formulation
US6207682B1 (en) 1998-12-22 2001-03-27 Novo Nordisk A/S Modified release formulations containing (R)-1-(10,11-dihydro-5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1propyl)-3-piperidinecarboxylic acid
US7355042B2 (en) * 2001-10-16 2008-04-08 Hypnion, Inc. Treatment of CNS disorders using CNS target modulators
US7541365B2 (en) * 2001-11-21 2009-06-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US20040087642A1 (en) * 2002-10-24 2004-05-06 Zeldis Jerome B. Methods of using and compositions comprising a JNK inhibitor for the treatment, prevention, management and/or modification of pain
TWI291467B (en) * 2002-11-13 2007-12-21 Millennium Pharm Inc CCR1 antagonists and methods of use therefor
WO2004112705A2 (en) * 2003-06-16 2004-12-29 Hypnion, Inc. Methods for treating sleep disorders
WO2008027521A1 (en) 2006-09-01 2008-03-06 Immune Control, Inc. Novel compositions and methods for treatment of diseases related to activated lymphocytes
WO2017040963A1 (en) 2015-09-03 2017-03-09 Forma Therapeutics, Inc. [6,6] fused bicyclic hdac8 inhibitors
CN110996932A (zh) 2017-07-13 2020-04-10 托尼克斯医药控股公司 环苯扎林和阿米替林的类似物
CN115850232B (zh) * 2023-02-16 2023-05-26 广州佳途科技股份有限公司 一种氟哌噻吨ep杂质h的制备方法及其应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2931810A (en) * 1960-04-05 Phenothiazine derivatives
US3316249A (en) * 1967-04-25 Part a.xmethyl n n-(z-diethylaminoethyl)-n-(z- nitrophenyl) anthranilate hydrochloride
NL97951C (enExample) * 1955-11-15
NL108827C (enExample) * 1956-04-09
NL99690C (enExample) * 1956-11-15
BE560750A (enExample) * 1957-07-26
NL222355A (enExample) * 1957-11-05
FR1216268A (fr) * 1958-04-24 1960-04-25 Rhone Poulenc Sa Nouveaux dérivés de la phénothiazine à chaîne pipéridine substituée par une fonction amide et leur préparation
US3069432A (en) * 1961-02-20 1962-12-18 Olin Mathieson 5-(aminoalkyl)-5, 11-dihydrodibenzo-oxazepines
DE1159954B (de) * 1961-11-25 1963-12-27 Boehringer & Soehne Gmbh Verfahren zur Herstellung neuer 10-(Alkoxypiperidinopropyl)-phenthiazine und ihrer Salze
US3157658A (en) * 1963-07-05 1964-11-17 Searle & Co 1-carbalkoxy-4-(9-xanthenyl) piperazines and related compounds
FR145F (enExample) * 1964-06-01
US3886170A (en) * 1974-04-22 1975-05-27 Robins Co Inc A H 5-(3-)SUBSTITUTED-10,11-DIHYDRO-5H-dibenz{8 b,f{9 azepines
US4888335A (en) * 1988-07-25 1989-12-19 Mcneilab, Inc. 3-alkoxy-2-aminopropyl heterocyclic amines and their use as cardiovascular agents
US5296602A (en) * 1991-03-18 1994-03-22 Sloan-Kettering Institute For Cancer Research Multisubstituted 1-hydroxy-9-acridones with anticancer activity
US5420123A (en) * 1992-12-21 1995-05-30 Bristol-Myers Squibb Company Dibenzodiazepine endothelin antagonists
US5538986A (en) * 1993-12-06 1996-07-23 Schering Corporation Tricyclic derivatives, compositions and methods of use
MY113463A (en) * 1994-01-04 2002-03-30 Novo Nordisk As Novel heterocyclic compounds

Also Published As

Publication number Publication date
FI962749L (fi) 1996-09-04
HU9601842D0 (en) 1996-09-30
CN1142226A (zh) 1997-02-05
KR100329450B1 (ko) 2002-10-04
CA2180238A1 (en) 1995-07-13
BR9506452A (pt) 1997-09-02
BG100692A (en) 1997-09-30
EP0738262A1 (en) 1996-10-23
RU2167152C2 (ru) 2001-05-20
PT738262E (pt) 2000-10-31
DE69516394T2 (de) 2000-10-26
CN1083431C (zh) 2002-04-24
CZ192196A3 (en) 1997-05-14
DE69516394D1 (de) 2000-05-25
JPH09507239A (ja) 1997-07-22
MY113463A (en) 2002-03-30
NO962811D0 (no) 1996-07-03
US5712292A (en) 1998-01-27
JP2944221B2 (ja) 1999-08-30
US5721254A (en) 1998-02-24
DK0738262T3 (da) 2000-09-04
NO962811L (no) 1996-09-04
UA47396C2 (uk) 2002-07-15
EP0738262B1 (en) 2000-04-19
US6043239A (en) 2000-03-28
SI9520023A (en) 1997-04-30
TW300887B (enExample) 1997-03-21
IL112222A (en) 1999-12-31
GR3033967T3 (en) 2000-11-30
US5795888A (en) 1998-08-18
FI114025B (fi) 2004-07-30
SK88196A3 (en) 1997-06-04
FI962749A0 (fi) 1996-07-04
US5668129A (en) 1997-09-16
AU1311095A (en) 1995-08-01
NO306295B1 (no) 1999-10-18
CZ286109B6 (cs) 2000-01-12
NZ277763A (en) 2001-11-30
US5595989A (en) 1997-01-21
ES2147837T3 (es) 2000-10-01
SG50602A1 (en) 1998-07-20
WO1995018793A1 (en) 1995-07-13
IL112222A0 (en) 1995-03-30
ATE191909T1 (de) 2000-05-15
US5693649A (en) 1997-12-02
HUT75878A (en) 1997-05-28
PL180209B1 (pl) 2001-01-31
AU691858B2 (en) 1998-05-28
US5688788A (en) 1997-11-18

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