PE28199A1 - Nuevos inhibidores de farnesil transferasa, su preparacion, las composiciones farmaceuticas que las contienen y su utilizacion para la preparacion de medicamentos - Google Patents
Nuevos inhibidores de farnesil transferasa, su preparacion, las composiciones farmaceuticas que las contienen y su utilizacion para la preparacion de medicamentosInfo
- Publication number
- PE28199A1 PE28199A1 PE1997001089A PE00108997A PE28199A1 PE 28199 A1 PE28199 A1 PE 28199A1 PE 1997001089 A PE1997001089 A PE 1997001089A PE 00108997 A PE00108997 A PE 00108997A PE 28199 A1 PE28199 A1 PE 28199A1
- Authority
- PE
- Peru
- Prior art keywords
- preparation
- transferasa
- farnesil
- inhibitors
- preference
- Prior art date
Links
- 229950008696 farnesil Drugs 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- -1 VINYLDIYL Chemical class 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/72—4,7-Endo-alkylene-iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9616206A FR2757855B1 (fr) | 1996-12-30 | 1996-12-30 | Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE28199A1 true PE28199A1 (es) | 1999-06-05 |
Family
ID=9499293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1997001089A PE28199A1 (es) | 1996-12-30 | 1997-12-03 | Nuevos inhibidores de farnesil transferasa, su preparacion, las composiciones farmaceuticas que las contienen y su utilizacion para la preparacion de medicamentos |
Country Status (32)
| Country | Link |
|---|---|
| EP (1) | EP0948483B1 (en, 2012) |
| JP (1) | JP2001509147A (en, 2012) |
| KR (1) | KR20000062391A (en, 2012) |
| AR (1) | AR008950A1 (en, 2012) |
| AT (1) | ATE214367T1 (en, 2012) |
| AU (1) | AU741921B2 (en, 2012) |
| BR (1) | BR9714498A (en, 2012) |
| CA (1) | CA2275943A1 (en, 2012) |
| CO (1) | CO4920252A1 (en, 2012) |
| CZ (1) | CZ233599A3 (en, 2012) |
| DE (1) | DE69711081T2 (en, 2012) |
| DK (1) | DK0948483T3 (en, 2012) |
| DZ (1) | DZ2389A1 (en, 2012) |
| EA (1) | EA002114B1 (en, 2012) |
| ES (1) | ES2172033T3 (en, 2012) |
| FR (1) | FR2757855B1 (en, 2012) |
| HU (1) | HUP0001747A3 (en, 2012) |
| ID (1) | ID22922A (en, 2012) |
| IL (1) | IL130453A0 (en, 2012) |
| MA (1) | MA26460A1 (en, 2012) |
| NO (1) | NO993225L (en, 2012) |
| NZ (1) | NZ336042A (en, 2012) |
| PE (1) | PE28199A1 (en, 2012) |
| PL (1) | PL334345A1 (en, 2012) |
| PT (1) | PT948483E (en, 2012) |
| SK (1) | SK88399A3 (en, 2012) |
| TN (1) | TNSN97214A1 (en, 2012) |
| TR (1) | TR199901502T2 (en, 2012) |
| UY (1) | UY24832A1 (en, 2012) |
| WO (1) | WO1998029390A1 (en, 2012) |
| YU (1) | YU30299A (en, 2012) |
| ZA (1) | ZA9711734B (en, 2012) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2787327B1 (fr) * | 1998-12-21 | 2003-01-17 | Aventis Pharma Sa | Compositions contenant des inhibiteurs de farnesyle transferase |
| FR2796641B1 (fr) * | 1999-07-22 | 2001-09-21 | Aventis Pharma Sa | Nouveau procede de preparation de composes benzoperhydroisoindole |
| FR2796640A1 (fr) * | 1999-07-22 | 2001-01-26 | Aventis Pharma Sa | Nouveaux inhibiteurs de farnesyle transferase, leur preparation, les compositions pharmaceutiques qui les contiennent et leur utilisation pour la preparation de medicaments |
| FR2845994B1 (fr) * | 2002-10-18 | 2006-05-19 | Servier Lab | Nouveaux derives de benzo[e][1,4]oxazino[3,2-g]isoindole substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2005089504A2 (en) * | 2004-03-18 | 2005-09-29 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
| WO2024229406A1 (en) | 2023-05-04 | 2024-11-07 | Revolution Medicines, Inc. | Combination therapy for a ras related disease or disorder |
| US20250154171A1 (en) | 2023-10-12 | 2025-05-15 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU681454B2 (en) * | 1993-11-05 | 1997-08-28 | Warner-Lambert Company | Substituted DI- and tripeptide inhibitors of protein:farnesyl transferase |
| FR2736641B1 (fr) * | 1995-07-10 | 1997-08-22 | Rhone Poulenc Rorer Sa | Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent |
-
1996
- 1996-12-30 FR FR9616206A patent/FR2757855B1/fr not_active Expired - Fee Related
-
1997
- 1997-12-03 PE PE1997001089A patent/PE28199A1/es not_active Application Discontinuation
- 1997-12-23 DK DK97953000T patent/DK0948483T3/da active
- 1997-12-23 KR KR1019997005966A patent/KR20000062391A/ko not_active Ceased
- 1997-12-23 CA CA002275943A patent/CA2275943A1/fr not_active Abandoned
- 1997-12-23 JP JP52968698A patent/JP2001509147A/ja not_active Ceased
- 1997-12-23 AT AT97953000T patent/ATE214367T1/de not_active IP Right Cessation
- 1997-12-23 EP EP97953000A patent/EP0948483B1/fr not_active Expired - Lifetime
- 1997-12-23 SK SK883-99A patent/SK88399A3/sk unknown
- 1997-12-23 EA EA199900608A patent/EA002114B1/ru not_active IP Right Cessation
- 1997-12-23 WO PCT/FR1997/002407 patent/WO1998029390A1/fr not_active Application Discontinuation
- 1997-12-23 ES ES97953000T patent/ES2172033T3/es not_active Expired - Lifetime
- 1997-12-23 HU HU0001747A patent/HUP0001747A3/hu unknown
- 1997-12-23 IL IL13045397A patent/IL130453A0/xx unknown
- 1997-12-23 BR BR9714498A patent/BR9714498A/pt not_active IP Right Cessation
- 1997-12-23 ID IDW990618A patent/ID22922A/id unknown
- 1997-12-23 TR TR1999/01502T patent/TR199901502T2/xx unknown
- 1997-12-23 PL PL97334345A patent/PL334345A1/xx unknown
- 1997-12-23 NZ NZ336042A patent/NZ336042A/xx unknown
- 1997-12-23 AU AU56694/98A patent/AU741921B2/en not_active Ceased
- 1997-12-23 YU YU30299A patent/YU30299A/sh unknown
- 1997-12-23 DE DE69711081T patent/DE69711081T2/de not_active Expired - Fee Related
- 1997-12-23 CZ CZ992335A patent/CZ233599A3/cs unknown
- 1997-12-23 PT PT97953000T patent/PT948483E/pt unknown
- 1997-12-26 MA MA24915A patent/MA26460A1/fr unknown
- 1997-12-26 TN TNTNSN97214A patent/TNSN97214A1/fr unknown
- 1997-12-27 DZ DZ970239A patent/DZ2389A1/xx active
- 1997-12-29 CO CO97075391A patent/CO4920252A1/es unknown
- 1997-12-30 UY UY24832A patent/UY24832A1/es not_active Application Discontinuation
- 1997-12-30 ZA ZA9711734A patent/ZA9711734B/xx unknown
- 1997-12-30 AR ARP970106263A patent/AR008950A1/es unknown
-
1999
- 1999-06-29 NO NO993225A patent/NO993225L/no not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |