PE20212329A1 - Derivados de pladeniolida como agentes dirigidos a empalmosoma para tratar el cancer - Google Patents

Derivados de pladeniolida como agentes dirigidos a empalmosoma para tratar el cancer

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Publication number
PE20212329A1
PE20212329A1 PE2020001580A PE2020001580A PE20212329A1 PE 20212329 A1 PE20212329 A1 PE 20212329A1 PE 2020001580 A PE2020001580 A PE 2020001580A PE 2020001580 A PE2020001580 A PE 2020001580A PE 20212329 A1 PE20212329 A1 PE 20212329A1
Authority
PE
Peru
Prior art keywords
independently selected
pladeniolide
splicing
derivatives
treat cancer
Prior art date
Application number
PE2020001580A
Other languages
English (en)
Spanish (es)
Inventor
Andrew Cook
Dominic Reynolds
Cheng Zhong
Ryan Brawn
Shelby Ellery
Thiwanka Samarakoon
Xiang Liu
Sudeep Prajapati
Megan Sheehan
Jason T Lowe
James Palacino
Original Assignee
Eisai Randd Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Randd Man Co Ltd filed Critical Eisai Randd Man Co Ltd
Publication of PE20212329A1 publication Critical patent/PE20212329A1/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/365—Lactones
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    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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