JP7334181B2 - 癌治療用のスプライセオソームターゲティング薬剤としてのプラジエノライド誘導体 - Google Patents
癌治療用のスプライセオソームターゲティング薬剤としてのプラジエノライド誘導体 Download PDFInfo
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- JP7334181B2 JP7334181B2 JP2020555482A JP2020555482A JP7334181B2 JP 7334181 B2 JP7334181 B2 JP 7334181B2 JP 2020555482 A JP2020555482 A JP 2020555482A JP 2020555482 A JP2020555482 A JP 2020555482A JP 7334181 B2 JP7334181 B2 JP 7334181B2
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| CN115944739B (zh) * | 2022-12-30 | 2023-12-19 | 深圳开悦生命科技有限公司 | Rna解旋酶dhx33抑制剂在制备用于治疗黑色素瘤的药物中的应用 |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002060890A1 (en) | 2001-02-01 | 2002-08-08 | Mercian Corporation | Novel physiologically active substances |
| WO2007110704A2 (en) | 2005-09-28 | 2007-10-04 | Novimmune Sa | Macrolide compositions as therapeutic agent |
| WO2008111466A1 (ja) | 2007-03-05 | 2008-09-18 | Eisai R & D Management Co., Ltd. | 遺伝子の発現量減少を指標とする抗ガン剤の作用検定方法 |
| WO2008111464A1 (ja) | 2007-03-05 | 2008-09-18 | Eisai R & D Management Co., Ltd. | スプライシング異常を指標とする抗ガン剤の作用検定方法 |
| US20140275010A1 (en) | 2013-03-12 | 2014-09-18 | Guo Zhu Zheng | Quaternary salts |
| JP2017505282A (ja) | 2014-05-15 | 2017-02-16 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | プラジエノライドピリジン化合物及び使用の方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2017507C (en) | 1989-05-25 | 1996-11-12 | Gary Van Nest | Adjuvant formulation comprising a submicron oil droplet emulsion |
| AU705688B2 (en) | 1995-11-10 | 1999-05-27 | Cytogen Corporation | Peptides which enhance transport across tissues and methods of identifying and using the same |
| EP1212422B1 (en) | 1999-08-24 | 2007-02-21 | Medarex, Inc. | Human ctla-4 antibodies and their uses |
| TWI334866B (en) | 2002-05-29 | 2010-12-21 | Mercian Corp | Novel physiologically active substances |
| JP4459051B2 (ja) | 2002-07-31 | 2010-04-28 | メルシャン株式会社 | 新規生理活性物質 |
| CA2494536C (en) | 2002-07-31 | 2011-10-04 | Mercian Corporation | A 12-membered ring macrolide active substance |
| AU2003285012A1 (en) | 2002-10-24 | 2004-05-13 | Sepracor, Inc. | Compositions comprising zopiclone derivatives and methods of making and using the same |
| BR0316746A (pt) | 2002-11-29 | 2005-10-18 | Mercian Corp | Método de produção do composto macrolida 11107d, linhagem streptomyces sp.ab-1704 (ferm bp-8551), linhagem mortierella sp. f1529 (ferm bp-8547) ou linhagem f-1530 (ferm bp-8548), e linhagem ab-1896 (ferm bp-8550) |
| CN1886505A (zh) | 2003-11-27 | 2006-12-27 | 美露香株式会社 | 参与大环内酯类化合物的羟化作用的dna |
| WO2005075681A1 (ja) | 2004-02-06 | 2005-08-18 | Eisai R & D Management Co., Ltd. | 抗癌剤に対する癌細胞の感受性を検定する方法 |
| US8008049B2 (en) | 2004-07-20 | 2011-08-30 | Eisai R&D Management Co., Ltd. | DNA coding for polypeptide participating in biosynthesis of pladienolide |
| JPWO2007043621A1 (ja) | 2005-10-13 | 2009-04-16 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | プラジエノライドb及びプラジエノライドdの全合成方法 |
| US7790887B2 (en) | 2007-01-29 | 2010-09-07 | Eisai R&D Management Co., Ltd. | Macrolide compound in solid form, process for preparation thereof, and pharmaceutical composition containing the same |
| US20080312317A1 (en) | 2007-04-12 | 2008-12-18 | Eisai R&D Management Co., Ltd. | 12 membered-ring macrolactam derivatives |
| WO2009008492A1 (ja) | 2007-07-06 | 2009-01-15 | Eisai R & D Management Co., Ltd. | マクロライド系化合物の製造方法およびその製造中間体 |
| BRPI0818003A2 (pt) * | 2007-10-18 | 2019-09-24 | Novartis Ag | inibidores de csf-1r, composições e métodos de uso |
| WO2013148324A1 (en) | 2012-03-26 | 2013-10-03 | The Regents Of The University Of California | Anti-cancer polyketide compounds |
| HK1203971A1 (en) | 2012-05-15 | 2015-11-06 | Bristol-Myers Squibb Company | Cancer immunotherapy by disrupting pd-1/pd-l1 signaling |
| EP2906212A4 (en) * | 2012-10-15 | 2016-06-08 | Agios Pharmaceuticals Inc | THERAPEUTIC COMPOUNDS AND COMPOSITIONS |
| RU2715038C2 (ru) | 2014-07-11 | 2020-02-21 | Дженентек, Инк. | Антитела анти-pd-l1 и способы их диагностического применения |
| BR112018009995B1 (pt) | 2015-11-18 | 2024-04-30 | Eisai R&D Management Co., Ltd | Forma cristalina, composição farmacêutica, e, uso da forma cristalina |
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002060890A1 (en) | 2001-02-01 | 2002-08-08 | Mercian Corporation | Novel physiologically active substances |
| WO2007110704A2 (en) | 2005-09-28 | 2007-10-04 | Novimmune Sa | Macrolide compositions as therapeutic agent |
| WO2008111466A1 (ja) | 2007-03-05 | 2008-09-18 | Eisai R & D Management Co., Ltd. | 遺伝子の発現量減少を指標とする抗ガン剤の作用検定方法 |
| WO2008111464A1 (ja) | 2007-03-05 | 2008-09-18 | Eisai R & D Management Co., Ltd. | スプライシング異常を指標とする抗ガン剤の作用検定方法 |
| US20140275010A1 (en) | 2013-03-12 | 2014-09-18 | Guo Zhu Zheng | Quaternary salts |
| JP2017505282A (ja) | 2014-05-15 | 2017-02-16 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | プラジエノライドピリジン化合物及び使用の方法 |
Non-Patent Citations (1)
| Title |
|---|
| MULLER,S. et al.,Synthesis of a Pladienolide B Analogue with the Fully Functionalized Core Structure,Organic Letters,2011年,Vol.13, No.15,p.3940-3943 |
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