PH12020500665A1 - Pladienolide derivatives as spliceosome targeting agents for treating cancer - Google Patents

Pladienolide derivatives as spliceosome targeting agents for treating cancer

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Publication number
PH12020500665A1
PH12020500665A1 PH12020500665A PH12020500665A PH12020500665A1 PH 12020500665 A1 PH12020500665 A1 PH 12020500665A1 PH 12020500665 A PH12020500665 A PH 12020500665A PH 12020500665 A PH12020500665 A PH 12020500665A PH 12020500665 A1 PH12020500665 A1 PH 12020500665A1
Authority
PH
Philippines
Prior art keywords
pladienolide
spliceosome
compounds
treating cancer
targeting agents
Prior art date
Application number
PH12020500665A
Other languages
English (en)
Inventor
Andrew Cook
Jason T Lowe
Sudeep Prajapati
Thiwanka Samarakoon
Ryan Brawn
Dominic Reynolds
Cheng Zhong
Shelby Ellery
Xiang Liu
Megan Sheehan
James Palacino
Original Assignee
Eisai R And D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R And D Man Co Ltd filed Critical Eisai R And D Man Co Ltd
Publication of PH12020500665A1 publication Critical patent/PH12020500665A1/en

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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