MX2018002932A - Sintesis y composicion de agentes terapeuticos fotodinamicos para el tratamiento dirigido del cancer. - Google Patents
Sintesis y composicion de agentes terapeuticos fotodinamicos para el tratamiento dirigido del cancer.Info
- Publication number
- MX2018002932A MX2018002932A MX2018002932A MX2018002932A MX2018002932A MX 2018002932 A MX2018002932 A MX 2018002932A MX 2018002932 A MX2018002932 A MX 2018002932A MX 2018002932 A MX2018002932 A MX 2018002932A MX 2018002932 A MX2018002932 A MX 2018002932A
- Authority
- MX
- Mexico
- Prior art keywords
- cancer
- synthesis
- composition
- therapeutic agents
- compounds
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 210000001519 tissue Anatomy 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000002675 image-guided surgery Methods 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000003470 mitochondria Anatomy 0.000 abstract 1
- 238000002428 photodynamic therapy Methods 0.000 abstract 1
- 230000010837 receptor-mediated endocytosis Effects 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0076—PDT with expanded (metallo)porphyrins, i.e. having more than 20 ring atoms, e.g. texaphyrins, sapphyrins, hexaphyrins, pentaphyrins, porphocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
- A61K47/551—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds one of the codrug's components being a vitamin, e.g. niacinamide, vitamin B3, cobalamin, vitamin B12, folate, vitamin A or retinoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0052—Small organic molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/006—Palladium compounds
- C07F15/0066—Palladium compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención describe nuevos compuestos que son útiles para cirugía guiada por imagen y terapia fotodinámica. En particular los compuestos pueden dirigirse al núcleo o las mitocondrias después de que los compuestos se suministraron a tejidos enfermos tal como cáncer utilizando un ligando que dirige el receptor que se expresa sobre el tejido enfermo y seguido por endocitosis mediada por el receptor y proporciona la actividad efectiva contra las células de cáncer así como otros trastornos. Se describen métodos y composiciones para uso de los mismos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562216148P | 2015-09-09 | 2015-09-09 | |
PCT/US2016/050482 WO2017044445A1 (en) | 2015-09-09 | 2016-09-07 | Synthesis and composition of photodynamic therapeutic agents for the targeted treatment of cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018002932A true MX2018002932A (es) | 2018-09-12 |
Family
ID=58239886
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018002932A MX2018002932A (es) | 2015-09-09 | 2016-09-07 | Sintesis y composicion de agentes terapeuticos fotodinamicos para el tratamiento dirigido del cancer. |
Country Status (10)
Country | Link |
---|---|
US (1) | US10676487B2 (es) |
EP (1) | EP3347010A4 (es) |
JP (1) | JP2018537402A (es) |
KR (1) | KR20180081494A (es) |
CN (1) | CN108135885A (es) |
AU (1) | AU2016318606A1 (es) |
CA (1) | CA2996307A1 (es) |
IL (1) | IL257670A (es) |
MX (1) | MX2018002932A (es) |
WO (2) | WO2017044445A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3060567B1 (fr) * | 2016-12-19 | 2019-05-24 | Ecole Normale Superieure De Lyon | Substrat de glycosidase fluorogene et procede de detection associe |
JP7447384B2 (ja) * | 2018-06-21 | 2024-03-12 | オスロ ウニヴェルスィテーツスィーケフース ハーエフ | 方法 |
CN111748002B (zh) * | 2019-03-14 | 2022-03-29 | 北京和益源生物技术有限公司 | 一种脱氧葡萄糖修饰的叶酸衍生物及其合成与应用 |
CN111714640B (zh) * | 2019-03-14 | 2023-02-14 | 北京和益源生物技术有限公司 | 一种糖修饰的叶酸衍生物制备的纳米运载颗粒及其应用 |
CN112028898B (zh) * | 2019-06-04 | 2023-06-23 | 康宏耀源(天津)科技有限公司 | 不同连接链偶联的叶酸靶向卟吩类光敏剂及其合成和应用 |
KR102329966B1 (ko) | 2020-03-23 | 2021-11-23 | 전남대학교산학협력단 | 양친성 고분자 화합물, 이를 이용한 약물 전달체 및 종양 치료 시스템 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6093382A (en) | 1998-05-16 | 2000-07-25 | Bracco Research Usa Inc. | Metal complexes derivatized with folate for use in diagnostic and therapeutic applications |
CA2387380C (en) | 1999-10-08 | 2011-08-02 | Robert C. Leif | Conjugated polymer tag complexes |
US7943586B2 (en) | 2003-06-09 | 2011-05-17 | The Trustees Of The University Of Pennsylvania | Antineoplastic agents targeted via glut transporters |
US9957293B2 (en) | 2006-08-23 | 2018-05-01 | Yeda Research And Development Company Ltd. | Conjugates of RGD peptides and porphyrin or (bacterio)chlorophyll photosynthesizers and their uses |
WO2008039994A2 (en) | 2006-09-28 | 2008-04-03 | The Trustees Of The University Of Pennsylvania | Targeted photodynamic therapy agent |
BRPI0812970A2 (pt) | 2007-06-25 | 2019-09-24 | Endocyte Inc | conjugados contendo espaçadores hidrofílicos |
EP2431366B1 (en) | 2009-04-29 | 2014-04-09 | Diatech Korea Co., Ltd. | New chlorin e6-folic acid conjugated compound, preparation method thereof, and pharmaceutical composition containing the same for treatment of cancer |
US8940664B2 (en) | 2010-11-22 | 2015-01-27 | E I Du Pont De Nemours And Company | Oil release with polyethylene oxide segment-containing N-lauroyl amino acid-based compounds |
GB201101429D0 (en) * | 2011-01-27 | 2011-03-16 | Biocompatibles Uk Ltd | Drug delivery system |
KR101344303B1 (ko) * | 2011-10-07 | 2013-12-24 | 동성제약주식회사 | 표적 치료에 관한 종양에 선택성이 있는 콘쥬게이트 |
-
2016
- 2016-09-06 US US15/257,566 patent/US10676487B2/en active Active
- 2016-09-07 MX MX2018002932A patent/MX2018002932A/es unknown
- 2016-09-07 AU AU2016318606A patent/AU2016318606A1/en not_active Abandoned
- 2016-09-07 CA CA2996307A patent/CA2996307A1/en not_active Abandoned
- 2016-09-07 CN CN201680059632.2A patent/CN108135885A/zh active Pending
- 2016-09-07 EP EP16844950.2A patent/EP3347010A4/en not_active Withdrawn
- 2016-09-07 JP JP2018512409A patent/JP2018537402A/ja active Pending
- 2016-09-07 WO PCT/US2016/050482 patent/WO2017044445A1/en active Application Filing
- 2016-09-07 KR KR1020187009906A patent/KR20180081494A/ko unknown
- 2016-09-07 WO PCT/US2016/050478 patent/WO2017044443A1/en active Application Filing
-
2018
- 2018-02-21 IL IL257670A patent/IL257670A/en unknown
Also Published As
Publication number | Publication date |
---|---|
IL257670A (en) | 2018-04-30 |
AU2016318606A1 (en) | 2018-04-05 |
KR20180081494A (ko) | 2018-07-16 |
CN108135885A (zh) | 2018-06-08 |
US10676487B2 (en) | 2020-06-09 |
CA2996307A1 (en) | 2017-03-16 |
US20170145035A1 (en) | 2017-05-25 |
WO2017044445A1 (en) | 2017-03-16 |
EP3347010A1 (en) | 2018-07-18 |
EP3347010A4 (en) | 2019-04-10 |
JP2018537402A (ja) | 2018-12-20 |
WO2017044443A1 (en) | 2017-03-16 |
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