PE20210160A1 - Moduladores de nlrp3 - Google Patents
Moduladores de nlrp3Info
- Publication number
- PE20210160A1 PE20210160A1 PE2020001652A PE2020001652A PE20210160A1 PE 20210160 A1 PE20210160 A1 PE 20210160A1 PE 2020001652 A PE2020001652 A PE 2020001652A PE 2020001652 A PE2020001652 A PE 2020001652A PE 20210160 A1 PE20210160 A1 PE 20210160A1
- Authority
- PE
- Peru
- Prior art keywords
- compounds
- quinolin
- pyrazolo
- pyrazol
- halo
- Prior art date
Links
- 102000000874 Pyrin Domain-Containing 3 Protein NLR Family Human genes 0.000 title abstract 2
- 108010001946 Pyrin Domain-Containing 3 Protein NLR Family Proteins 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- PMUOEIBHDNKLDY-UHFFFAOYSA-N 2-(4-amino-7-pyrazol-1-ylpyrazolo[4,3-c]quinolin-2-yl)ethanol Chemical compound NC1=NC=2C=C(C=CC=2C=2C1=CN(N=2)CCO)N1N=CC=C1 PMUOEIBHDNKLDY-UHFFFAOYSA-N 0.000 abstract 1
- WTXFZXGGOCEKNM-UHFFFAOYSA-N 3-[4-amino-7-(1H-pyrazol-5-yl)pyrazolo[3,4-c]quinolin-2-yl]propan-1-ol Chemical compound NC1=NC=2C=C(C=CC=2C=2C1=NN(C=2)CCCO)C1=NNC=C1 WTXFZXGGOCEKNM-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862662240P | 2018-04-25 | 2018-04-25 | |
| US201862764818P | 2018-08-16 | 2018-08-16 | |
| US201962825044P | 2019-03-28 | 2019-03-28 | |
| PCT/US2019/028823 WO2019209896A1 (en) | 2018-04-25 | 2019-04-24 | Nlrp3 modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20210160A1 true PE20210160A1 (es) | 2021-01-26 |
Family
ID=66677224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2020001652A PE20210160A1 (es) | 2018-04-25 | 2019-04-24 | Moduladores de nlrp3 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US12037344B2 (OSRAM) |
| EP (2) | EP4353235A3 (OSRAM) |
| JP (2) | JP7351850B2 (OSRAM) |
| KR (1) | KR102711180B1 (OSRAM) |
| CN (2) | CN112521387B (OSRAM) |
| AU (1) | AU2019261582A1 (OSRAM) |
| BR (1) | BR112020021539A2 (OSRAM) |
| CA (1) | CA3097865A1 (OSRAM) |
| CL (1) | CL2020002719A1 (OSRAM) |
| CO (2) | CO2021006672A2 (OSRAM) |
| ES (1) | ES2971122T3 (OSRAM) |
| IL (1) | IL278173A (OSRAM) |
| MX (1) | MX2020011234A (OSRAM) |
| NZ (1) | NZ769136A (OSRAM) |
| PE (1) | PE20210160A1 (OSRAM) |
| SG (1) | SG11202010463TA (OSRAM) |
| TW (1) | TW202014420A (OSRAM) |
| WO (1) | WO2019209896A1 (OSRAM) |
| ZA (1) | ZA202007307B (OSRAM) |
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| JP7573622B2 (ja) * | 2020-01-10 | 2024-10-25 | イネイト・テューマー・イミュニティ・インコーポレイテッド | Ｎｌｒｐ３モジュレーター |
| WO2021150613A1 (en) | 2020-01-20 | 2021-07-29 | Incyte Corporation | Spiro compounds as inhibitors of kras |
| CA3179692A1 (en) * | 2020-04-16 | 2021-10-21 | Incyte Corporation | Fused tricyclic kras inhibitors |
| JP2023523756A (ja) | 2020-04-30 | 2023-06-07 | ヤンセン ファーマシューティカ エヌ．ベー． | 新規なトリアジノインドール化合物 |
| WO2021231526A1 (en) | 2020-05-13 | 2021-11-18 | Incyte Corporation | Fused pyrimidine compounds as kras inhibitors |
| CA3177672A1 (en) * | 2020-05-28 | 2021-12-02 | Michael Eric MURATORE | Compounds |
| CN116390923B (zh) * | 2020-08-21 | 2025-08-29 | 浙江海正药业股份有限公司 | 杂环类衍生物及其制备方法和用途 |
| US11999752B2 (en) | 2020-08-28 | 2024-06-04 | Incyte Corporation | Vinyl imidazole compounds as inhibitors of KRAS |
| WO2022072783A1 (en) | 2020-10-02 | 2022-04-07 | Incyte Corporation | Bicyclic dione compounds as inhibitors of kras |
| EP3984535A1 (en) * | 2020-10-16 | 2022-04-20 | Albert-Ludwigs-Universität Freiburg | Nlrp3 activators for use in the treatment of infectious diseases or cancer by activating nlrp3 inflammasome |
| US20240101570A1 (en) * | 2020-11-24 | 2024-03-28 | Amgen Inc. | Tricyclic carboxamide derivatives as prmt5 inhibitors |
| CN114539095A (zh) * | 2020-11-26 | 2022-05-27 | 乐凯化学材料有限公司 | 3-（4-羟基-3-甲氧基-苯基）-2-氰基-2-丙烯酸乙酯的制备方法 |
| WO2022204112A1 (en) | 2021-03-22 | 2022-09-29 | Incyte Corporation | Imidazole and triazole kras inhibitors |
| AU2022306671A1 (en) | 2021-07-07 | 2024-01-25 | Incyte Corporation | Tricyclic compounds as inhibitors of kras |
| JP2024529347A (ja) | 2021-07-14 | 2024-08-06 | インサイト・コーポレイション | Ｋｒａｓの阻害剤としての三環式化合物 |
| US20240254132A1 (en) * | 2021-07-16 | 2024-08-01 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| JP2024534187A (ja) | 2021-08-31 | 2024-09-18 | インサイト・コーポレイション | Ｋｒａｓの阻害剤としてのナフチリジン化合物 |
| WO2023049697A1 (en) | 2021-09-21 | 2023-03-30 | Incyte Corporation | Hetero-tricyclic compounds as inhibitors of kras |
| EP4408536A1 (en) | 2021-10-01 | 2024-08-07 | Incyte Corporation | Pyrazoloquinoline kras inhibitors |
| KR20240101561A (ko) | 2021-10-14 | 2024-07-02 | 인사이트 코포레이션 | Kras의 저해제로서의 퀴놀린 화합물 |
| WO2025190317A1 (en) * | 2024-03-13 | 2025-09-18 | National Institute Of Biological Sciences, Beijing | Urea compounds as nlrp3 agonists |
| WO2026006603A1 (en) * | 2024-06-26 | 2026-01-02 | Wisconsin Alumni Research Foundation | Tlr7/tlr8 agonists for use in trifunctional radiopharmaceutical compounds |
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| BR112018071347A2 (pt) | 2016-04-19 | 2019-02-05 | Innate Tumor Immunity Inc | moduladores de nlrp3 |
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-
2019
- 2019-04-24 CN CN202011468364.4A patent/CN112521387B/zh active Active
- 2019-04-24 KR KR1020207033384A patent/KR102711180B1/ko active Active
- 2019-04-24 WO PCT/US2019/028823 patent/WO2019209896A1/en not_active Ceased
- 2019-04-24 EP EP23211253.2A patent/EP4353235A3/en active Pending
- 2019-04-24 MX MX2020011234A patent/MX2020011234A/es unknown
- 2019-04-24 CA CA3097865A patent/CA3097865A1/en active Pending
- 2019-04-24 EP EP19727780.9A patent/EP3784670B1/en active Active
- 2019-04-24 JP JP2020559472A patent/JP7351850B2/ja active Active
- 2019-04-24 ES ES19727780T patent/ES2971122T3/es active Active
- 2019-04-24 AU AU2019261582A patent/AU2019261582A1/en not_active Abandoned
- 2019-04-24 CN CN201980027881.7A patent/CN112074516A/zh active Pending
- 2019-04-24 NZ NZ769136A patent/NZ769136A/en unknown
- 2019-04-24 PE PE2020001652A patent/PE20210160A1/es unknown
- 2019-04-24 BR BR112020021539-2A patent/BR112020021539A2/pt not_active IP Right Cessation
- 2019-04-24 US US17/049,612 patent/US12037344B2/en active Active
- 2019-04-24 SG SG11202010463TA patent/SG11202010463TA/en unknown
- 2019-04-25 TW TW108114491A patent/TW202014420A/zh unknown
-
2020
- 2020-10-20 IL IL278173A patent/IL278173A/en unknown
- 2020-10-21 CL CL2020002719A patent/CL2020002719A1/es unknown
- 2020-10-21 CO CONC2021/0006672A patent/CO2021006672A2/es unknown
- 2020-10-21 CO CONC2020/0013155A patent/CO2020013155A2/es unknown
- 2020-11-24 ZA ZA2020/07307A patent/ZA202007307B/en unknown
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2023
- 2023-09-14 JP JP2023149057A patent/JP7660634B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA3097865A1 (en) | 2019-10-31 |
| BR112020021539A2 (pt) | 2021-01-19 |
| CN112521387B (zh) | 2023-08-22 |
| CO2021006672A2 (es) | 2021-06-10 |
| MX2020011234A (es) | 2020-11-11 |
| US20210267964A1 (en) | 2021-09-02 |
| JP2024001030A (ja) | 2024-01-09 |
| EP4353235A2 (en) | 2024-04-17 |
| JP7351850B2 (ja) | 2023-09-27 |
| KR20210005106A (ko) | 2021-01-13 |
| CO2020013155A2 (es) | 2021-06-10 |
| EP3784670A1 (en) | 2021-03-03 |
| EP3784670B1 (en) | 2023-11-29 |
| AU2019261582A1 (en) | 2020-11-12 |
| TW202014420A (zh) | 2020-04-16 |
| JP2021522249A (ja) | 2021-08-30 |
| US12037344B2 (en) | 2024-07-16 |
| ES2971122T3 (es) | 2024-06-03 |
| CN112521387A (zh) | 2021-03-19 |
| JP7660634B2 (ja) | 2025-04-11 |
| CN112074516A (zh) | 2020-12-11 |
| KR102711180B1 (ko) | 2024-09-26 |
| EP4353235A3 (en) | 2024-07-31 |
| SG11202010463TA (en) | 2020-11-27 |
| NZ769136A (en) | 2024-04-26 |
| WO2019209896A1 (en) | 2019-10-31 |
| CL2020002719A1 (es) | 2020-12-18 |
| IL278173A (en) | 2020-11-30 |
| ZA202007307B (en) | 2023-01-25 |
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