PE20201169A1 - Metodo de produccion de un compuesto intermedio para sintetizar un medicamento - Google Patents

Metodo de produccion de un compuesto intermedio para sintetizar un medicamento

Info

Publication number
PE20201169A1
PE20201169A1 PE2020000587A PE2020000587A PE20201169A1 PE 20201169 A1 PE20201169 A1 PE 20201169A1 PE 2020000587 A PE2020000587 A PE 2020000587A PE 2020000587 A PE2020000587 A PE 2020000587A PE 20201169 A1 PE20201169 A1 PE 20201169A1
Authority
PE
Peru
Prior art keywords
synthesize
compound
production
increase
intermediate compound
Prior art date
Application number
PE2020000587A
Other languages
English (en)
Inventor
Seok Ju Lee
Bongchan Kim
Ae Ri Park
In Ae Ryu
Jongwon Park
Original Assignee
Lg Chemical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Chemical Ltd filed Critical Lg Chemical Ltd
Priority claimed from PCT/KR2018/011565 external-priority patent/WO2019066578A1/ko
Publication of PE20201169A1 publication Critical patent/PE20201169A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invencion se refiere a un metodo para la preparacion de un compuesto de formula quimica 2, donde P1 es es un grupo carbonilo, acilo, sulfonilo, acetilo o bencilo como un grupo protector de amina y P2 es un grupo protector de acido carboxilico. Dicho compuesto es un intermedio usado para sintetizar agentes antidiabeticos que inhiben la enzima dipeptidil peptidasa IV, que 1) puede producirlo con alta pureza a traves 5 de una ciclacion y desciclacion de oxazolidinona que la convierte en una amida, 2) puede aumentar el rendimiento y aumentar la productividad a traves de la estabilizacion del procedimiento de preparacion, y 3) puede lograr un efecto de mejora tal como la reduccion del coste de materias primas, etc. usando un material de partida de una muestra economica.
PE2020000587A 2017-09-28 2018-09-28 Metodo de produccion de un compuesto intermedio para sintetizar un medicamento PE20201169A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20170126119 2017-09-28
PCT/KR2018/011565 WO2019066578A1 (ko) 2017-09-28 2018-09-28 의약품 합성용 중간체 화합물의 제조 방법
KR1020180115838A KR102152445B1 (ko) 2017-09-28 2018-09-28 의약품 합성용 중간체 화합물의 제조 방법

Publications (1)

Publication Number Publication Date
PE20201169A1 true PE20201169A1 (es) 2020-10-28

Family

ID=66104057

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2020000587A PE20201169A1 (es) 2017-09-28 2018-09-28 Metodo de produccion de un compuesto intermedio para sintetizar un medicamento

Country Status (8)

Country Link
KR (1) KR102152445B1 (es)
CN (1) CN111164071A (es)
BR (1) BR112020006063B1 (es)
CL (1) CL2020000807A1 (es)
CO (1) CO2020005226A2 (es)
PE (1) PE20201169A1 (es)
PH (1) PH12020550170A1 (es)
RU (1) RU2742765C1 (es)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6267097A (ja) * 1985-09-18 1987-03-26 Nippon Kayaku Co Ltd α−アスパルチル−フエニルアラニンエステルの新規製造法
IT1248486B (it) * 1990-05-24 1995-01-19 Roberto Pellicciari Agente terapeutico ad attivita' sul sistema nervoso centrale
EP1745784A1 (en) * 2005-06-27 2007-01-24 Ferrer Internacional, S.A. Oxazolidinone derivatives and use thereof as antibiotics
MA34490B1 (fr) * 2010-09-03 2013-08-01 Lg Life Sciences Ltd Procede de production d'un compose intermediaire pour la synthese d'un medicament
US8524936B2 (en) * 2011-05-18 2013-09-03 Milan Soukup Manufacturing process for sitagliptin from L-aspartic acid

Also Published As

Publication number Publication date
KR102152445B1 (ko) 2020-09-04
CL2020000807A1 (es) 2020-08-07
RU2742765C1 (ru) 2021-02-10
BR112020006063A2 (pt) 2020-09-29
PH12020550170A1 (en) 2021-03-01
BR112020006063B1 (pt) 2024-01-16
KR20190037172A (ko) 2019-04-05
CO2020005226A2 (es) 2020-06-09
CN111164071A (zh) 2020-05-15

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