PE20210839A1 - Metodo de produccion de un compuesto intermedio para sintetizar un medicamento - Google Patents
Metodo de produccion de un compuesto intermedio para sintetizar un medicamentoInfo
- Publication number
- PE20210839A1 PE20210839A1 PE2020000586A PE2020000586A PE20210839A1 PE 20210839 A1 PE20210839 A1 PE 20210839A1 PE 2020000586 A PE2020000586 A PE 2020000586A PE 2020000586 A PE2020000586 A PE 2020000586A PE 20210839 A1 PE20210839 A1 PE 20210839A1
- Authority
- PE
- Peru
- Prior art keywords
- synthesize
- production
- intermediate compound
- medicinal product
- chemical formula
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000000126 substance Substances 0.000 abstract 2
- 108010067722 Dipeptidyl Peptidase 4 Proteins 0.000 abstract 1
- 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 abstract 1
- 230000003178 anti-diabetic effect Effects 0.000 abstract 1
- 125000006244 carboxylic acid protecting group Chemical group 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C31/02—Monohydroxylic acyclic alcohols
- C07C31/04—Methanol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/12—Saturated polycyclic compounds
- C07C61/125—Saturated polycyclic compounds having a carboxyl group bound to a condensed ring system
- C07C61/13—Saturated polycyclic compounds having a carboxyl group bound to a condensed ring system having two rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/10—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with ester groups or with a carbon-halogen bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invencion se refiere a un metodo de preparacion de formula quimica 1 que es un producto intermedio necesario para sintetizar antidiabeticos que inhiben la DPP-IV desprotegiendo selectivamente el grupo protector de acido carboxilico (P2) del compuesto de formula quimica 2.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20170153334 | 2017-11-16 | ||
PCT/KR2018/012575 WO2019098551A1 (ko) | 2017-11-16 | 2018-10-23 | 의약품 합성용 중간체 화합물의 제조 방법 |
KR1020180126663A KR102184129B1 (ko) | 2017-11-16 | 2018-10-23 | 의약품 합성용 중간체 화합물의 제조 방법 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20210839A1 true PE20210839A1 (es) | 2021-05-06 |
Family
ID=66680122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2020000586A PE20210839A1 (es) | 2017-11-16 | 2018-10-23 | Metodo de produccion de un compuesto intermedio para sintetizar un medicamento |
Country Status (8)
Country | Link |
---|---|
KR (1) | KR102184129B1 (es) |
CN (1) | CN111247127B (es) |
BR (1) | BR112020009568A2 (es) |
CL (1) | CL2020001285A1 (es) |
CO (1) | CO2020006788A2 (es) |
PE (1) | PE20210839A1 (es) |
PH (1) | PH12020550635A1 (es) |
RU (1) | RU2741389C1 (es) |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2721185A1 (de) * | 1977-05-11 | 1978-11-16 | Bayer Ag | Verfahren zur herstellung von substituierten vinylcyclopropancarbonsaeurebenzylestern |
JPH04316526A (ja) * | 1991-04-15 | 1992-11-06 | Asahi Chem Ind Co Ltd | カルボン酸エステルのアルカリ加水分解法 |
TW460452B (en) * | 1998-09-14 | 2001-10-21 | Rhodia Fiber & Amp Resin Inter | Process for the crystallization of carboxylic acid and process for manufacturing crystalline carboxylic acid |
TWI357902B (en) * | 2005-04-01 | 2012-02-11 | Lg Life Science Ltd | Dipeptidyl peptidase-iv inhibiting compounds, meth |
JP2008201719A (ja) * | 2007-02-20 | 2008-09-04 | Nippon Oil Corp | テトラカルボン酸およびその酸二無水物の製造方法 |
JP5358585B2 (ja) * | 2007-12-21 | 2013-12-04 | エルジー ライフ サイエンス リミテッド | ジペプチジルペプチダーゼ−iv阻害化合物、同化合物を製造する方法、及び活性剤として同化合物を含む医薬組成物 |
SG188329A1 (en) * | 2010-09-03 | 2013-04-30 | Lg Life Sciences Ltd | Production method of intermediate compound for synthesizing medicament |
-
2018
- 2018-10-23 BR BR112020009568-0A patent/BR112020009568A2/pt unknown
- 2018-10-23 PE PE2020000586A patent/PE20210839A1/es unknown
- 2018-10-23 KR KR1020180126663A patent/KR102184129B1/ko active IP Right Grant
- 2018-10-23 RU RU2020114746A patent/RU2741389C1/ru active
- 2018-10-23 CN CN201880067548.4A patent/CN111247127B/zh active Active
-
2020
- 2020-05-15 PH PH12020550635A patent/PH12020550635A1/en unknown
- 2020-05-15 CL CL2020001285A patent/CL2020001285A1/es unknown
- 2020-05-29 CO CONC2020/0006788A patent/CO2020006788A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN111247127A (zh) | 2020-06-05 |
RU2741389C1 (ru) | 2021-01-25 |
KR20190056296A (ko) | 2019-05-24 |
PH12020550635A1 (en) | 2021-02-22 |
BR112020009568A2 (pt) | 2021-03-09 |
CO2020006788A2 (es) | 2020-06-09 |
CL2020001285A1 (es) | 2020-10-23 |
CN111247127B (zh) | 2024-02-06 |
KR102184129B1 (ko) | 2020-11-27 |
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