CL2020001285A1 - Método de producción de un compuesto intermedio para sintetizar un medicamento. - Google Patents

Método de producción de un compuesto intermedio para sintetizar un medicamento.

Info

Publication number
CL2020001285A1
CL2020001285A1 CL2020001285A CL2020001285A CL2020001285A1 CL 2020001285 A1 CL2020001285 A1 CL 2020001285A1 CL 2020001285 A CL2020001285 A CL 2020001285A CL 2020001285 A CL2020001285 A CL 2020001285A CL 2020001285 A1 CL2020001285 A1 CL 2020001285A1
Authority
CL
Chile
Prior art keywords
synthesize
drug
production method
intermediate compound
protective group
Prior art date
Application number
CL2020001285A
Other languages
English (en)
Inventor
Seok Ju Lee
Bongchan Kim
In Ae Ryu
Jongwon Park
Original Assignee
Lg Chemical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Chemical Ltd filed Critical Lg Chemical Ltd
Publication of CL2020001285A1 publication Critical patent/CL2020001285A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/02—Monohydroxylic acyclic alcohols
    • C07C31/04—Methanol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/12—Saturated polycyclic compounds
    • C07C61/125—Saturated polycyclic compounds having a carboxyl group bound to a condensed ring system
    • C07C61/13—Saturated polycyclic compounds having a carboxyl group bound to a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/10—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with ester groups or with a carbon-halogen bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A UN MÉTODO DE PREPARACIÓN DE FÓRMULA QUÍMICA 1 QUE ES UN PRODUCTO INTERMEDIO NECESARIO PARA SINTETIZAR ANTIDIABÉTICOS QUE INHIBEN LA DPP-IV DESPROTEGIENDO SELECTIVAMENTE EL GRUPO PROTECTOR DE ÁCIDO CARBOXÍLICO (P2) DEL COMPUESTO DE FÓRMULA QUÍMICA 2.
CL2020001285A 2017-11-16 2020-05-15 Método de producción de un compuesto intermedio para sintetizar un medicamento. CL2020001285A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20170153334 2017-11-16
KR1020180126663A KR102184129B1 (ko) 2017-11-16 2018-10-23 의약품 합성용 중간체 화합물의 제조 방법

Publications (1)

Publication Number Publication Date
CL2020001285A1 true CL2020001285A1 (es) 2020-10-23

Family

ID=66680122

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2020001285A CL2020001285A1 (es) 2017-11-16 2020-05-15 Método de producción de un compuesto intermedio para sintetizar un medicamento.

Country Status (8)

Country Link
KR (1) KR102184129B1 (es)
CN (1) CN111247127B (es)
BR (1) BR112020009568A2 (es)
CL (1) CL2020001285A1 (es)
CO (1) CO2020006788A2 (es)
PE (1) PE20210839A1 (es)
PH (1) PH12020550635A1 (es)
RU (1) RU2741389C1 (es)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2721185A1 (de) * 1977-05-11 1978-11-16 Bayer Ag Verfahren zur herstellung von substituierten vinylcyclopropancarbonsaeurebenzylestern
JPH04316526A (ja) * 1991-04-15 1992-11-06 Asahi Chem Ind Co Ltd カルボン酸エステルのアルカリ加水分解法
TW460452B (en) * 1998-09-14 2001-10-21 Rhodia Fiber & Amp Resin Inter Process for the crystallization of carboxylic acid and process for manufacturing crystalline carboxylic acid
TWI357902B (en) * 2005-04-01 2012-02-11 Lg Life Science Ltd Dipeptidyl peptidase-iv inhibiting compounds, meth
JP2008201719A (ja) * 2007-02-20 2008-09-04 Nippon Oil Corp テトラカルボン酸およびその酸二無水物の製造方法
AU2008341352B2 (en) * 2007-12-21 2013-08-01 Lg Chem, Ltd. Dipeptidyl peptidase-IV inhibiting compounds, methods of preparing the same, and pharmaceutical compositions containing the same as active agent
ES2607089T3 (es) * 2010-09-03 2017-03-29 Lg Life Sciences Ltd Método de producción de un compuesto intermedio para sintetizar un medicamento

Also Published As

Publication number Publication date
PE20210839A1 (es) 2021-05-06
CN111247127B (zh) 2024-02-06
CO2020006788A2 (es) 2020-06-09
PH12020550635A1 (en) 2021-02-22
RU2741389C1 (ru) 2021-01-25
CN111247127A (zh) 2020-06-05
KR20190056296A (ko) 2019-05-24
KR102184129B1 (ko) 2020-11-27
BR112020009568A2 (pt) 2021-03-09

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