PE20180741A1 - Anticuerpo anti-cd154 con caracteristicas de union, funcionalidad y seguridad mejoradas y uso en inmunoterapia humana - Google Patents

Anticuerpo anti-cd154 con caracteristicas de union, funcionalidad y seguridad mejoradas y uso en inmunoterapia humana

Info

Publication number
PE20180741A1
PE20180741A1 PE2018000072A PE2018000072A PE20180741A1 PE 20180741 A1 PE20180741 A1 PE 20180741A1 PE 2018000072 A PE2018000072 A PE 2018000072A PE 2018000072 A PE2018000072 A PE 2018000072A PE 20180741 A1 PE20180741 A1 PE 20180741A1
Authority
PE
Peru
Prior art keywords
polypeptide
antibody
seq
human anti
functionality
Prior art date
Application number
PE2018000072A
Other languages
English (en)
Spanish (es)
Inventor
Jay Rothstein
Robert George Edward Holgate
Arron Hearn
Original Assignee
Immunext Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunext Inc filed Critical Immunext Inc
Publication of PE20180741A1 publication Critical patent/PE20180741A1/es

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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
PE2018000072A 2015-07-14 2016-07-13 Anticuerpo anti-cd154 con caracteristicas de union, funcionalidad y seguridad mejoradas y uso en inmunoterapia humana PE20180741A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562192269P 2015-07-14 2015-07-14
US201562197966P 2015-07-28 2015-07-28
US201662277201P 2016-01-11 2016-01-11

Publications (1)

Publication Number Publication Date
PE20180741A1 true PE20180741A1 (es) 2018-04-27

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Family Applications (1)

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PE2018000072A PE20180741A1 (es) 2015-07-14 2016-07-13 Anticuerpo anti-cd154 con caracteristicas de union, funcionalidad y seguridad mejoradas y uso en inmunoterapia humana

Country Status (22)

Country Link
US (3) US10874738B2 (https=)
EP (2) EP3331548B1 (https=)
JP (4) JP6826113B2 (https=)
KR (2) KR20250099272A (https=)
CN (2) CN114671952A (https=)
AU (3) AU2016294417B2 (https=)
CL (1) CL2018000103A1 (https=)
CO (1) CO2018001363A2 (https=)
CR (1) CR20180097A (https=)
DO (1) DOP2018000018A (https=)
EA (1) EA201890297A1 (https=)
EC (1) ECSP18009949A (https=)
GT (1) GT201800018A (https=)
HK (1) HK1249735A1 (https=)
IL (3) IL256800B2 (https=)
MX (2) MX2018000548A (https=)
MY (2) MY196991A (https=)
PE (1) PE20180741A1 (https=)
PH (1) PH12018500098A1 (https=)
SG (1) SG10201913431QA (https=)
TN (1) TN2018000021A1 (https=)
WO (1) WO2017011544A1 (https=)

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IL256800B2 (en) * 2015-07-14 2023-04-01 Immunext Inc An anti-cd154 antibody with improved binding, functional and safety properties and use in human immunotherapy
WO2017089618A1 (en) 2015-11-27 2017-06-01 Ablynx Nv Polypeptides inhibiting cd40l
CA3096222A1 (en) 2018-04-06 2019-10-10 Atyr Pharma, Inc. Compositions and methods comprising anti-nrp2 antibodies
WO2020056162A1 (en) * 2018-09-12 2020-03-19 Oregon Health & Science University Detecting and/or subtyping circulating hybrid cells that correlate with stage and survival
EP3856246A4 (en) * 2018-09-24 2022-07-20 Janssen Biotech, Inc. METHOD FOR ENSURING SAFE ADMINISTRATION OF ANTI-CD154 ANTIBODY
CN109453383A (zh) * 2018-11-12 2019-03-12 陈慧慧 免疫检查点的抑制剂在制备治疗青光眼及其他眼部免疫损伤机制相关疾病药物中的应用
US20220185785A1 (en) * 2019-04-12 2022-06-16 TONIX Pharmaceuticals Holding Corp Inhibitors of cd40-cd154 binding
CN114746120B (zh) * 2019-10-03 2024-07-30 Atyr医药公司 包含抗nrp2抗体的组合物和方法
CN113488170B (zh) * 2021-07-02 2023-07-25 温州医科大学 急性前葡萄膜炎复发风险预测模型构建方法及相关设备
EP4382537A4 (en) * 2021-07-30 2025-07-23 Seoul Nat Univ R&Db Foundation ANTI-CD154 ANTIBODY AND ITS USE
WO2023008982A1 (ko) * 2021-07-30 2023-02-02 서울대학교산학협력단 항 cd154 항체 및 이의 용도
WO2024211211A1 (en) 2023-04-03 2024-10-10 Regeneron Pharmaceuticals, Inc. Methods of improving transplant survival using il-2 receptor gamma chain antibodies
CN121358768A (zh) 2023-04-28 2026-01-16 信达生物制药(苏州)有限公司 抗cd40l抗体及其在人自身免疫疾病治疗的应用
IL324827A (en) * 2023-05-22 2026-01-01 Genzyme Corp Treating multiple sclerosis using anti-CD40L antibodies

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CN1871259A (zh) 2003-08-22 2006-11-29 比奥根艾迪克Ma公司 具有改变的效应物功能的经改进的抗体和制备它的方法
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CA2832281C (en) * 2011-04-04 2019-11-05 Trustees Of Dartmouth College Anti-cd154 antibodies having impaired fcr binding and/or complement binding properties and the use thereof in immune therapies
IL256800B2 (en) * 2015-07-14 2023-04-01 Immunext Inc An anti-cd154 antibody with improved binding, functional and safety properties and use in human immunotherapy

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IL297907A (en) 2023-01-01
IL310460A (en) 2024-03-01
AU2016294417A1 (en) 2018-03-08
NZ739859A (en) 2024-08-30
DOP2018000018A (es) 2019-10-15
KR20250099272A (ko) 2025-07-01
CO2018001363A2 (es) 2018-05-10
IL256800A (en) 2018-03-29
EP3331548B1 (en) 2026-04-15
HK1249735A1 (zh) 2018-11-09
AU2016294417B2 (en) 2022-08-04
CR20180097A (es) 2018-05-25
US20210145966A1 (en) 2021-05-20
AU2022263520A1 (en) 2022-12-08
JP2018528258A (ja) 2018-09-27
US10874738B2 (en) 2020-12-29
PH12018500098A1 (en) 2018-07-09
IL256800B2 (en) 2023-04-01
IL256800B (en) 2022-12-01
US11596689B2 (en) 2023-03-07
SG10201913431QA (en) 2020-03-30
MX2023014921A (es) 2024-02-16
GT201800018A (es) 2019-08-08
JP2025038055A (ja) 2025-03-18
IL297907B2 (en) 2024-07-01
CN108135969B (zh) 2022-03-04
JP6826113B2 (ja) 2021-02-03
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EA201890297A1 (ru) 2018-06-29
US20240000929A1 (en) 2024-01-04
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CN108135969A (zh) 2018-06-08
CL2018000103A1 (es) 2018-06-29
AU2022263520B2 (en) 2025-06-05
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