MX2018000548A - Anticuerpo anti-cd154 con características de unión, funcionalidad y seguridad mejoradas y uso en inmunoterapia humana. - Google Patents
Anticuerpo anti-cd154 con características de unión, funcionalidad y seguridad mejoradas y uso en inmunoterapia humana.Info
- Publication number
- MX2018000548A MX2018000548A MX2018000548A MX2018000548A MX2018000548A MX 2018000548 A MX2018000548 A MX 2018000548A MX 2018000548 A MX2018000548 A MX 2018000548A MX 2018000548 A MX2018000548 A MX 2018000548A MX 2018000548 A MX2018000548 A MX 2018000548A
- Authority
- MX
- Mexico
- Prior art keywords
- antibody
- functional
- improved binding
- safety characteristics
- human immunotherapy
- Prior art date
Links
- 238000009169 immunotherapy Methods 0.000 title 1
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 230000005784 autoimmunity Effects 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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- C07K2317/00—Immunoglobulins specific features
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- Health & Medical Sciences (AREA)
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Abstract
Se proporcionan en la presente invención anticuerpos anti-CD154 mejorados que tienen una potencia terapéutica, una vida media in vivo mejoradas y una unión a FcR y/o una unión/activación del complemento abolidas. Se describe en la presente invencion el uso de estos anticuerpos para inducir tolerancia y tratar enfermedades inmunes que incluyen autoinmunidad, inflamación, receptores de trasplantes, fibrosis y trastornos alérgicos.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562192269P | 2015-07-14 | 2015-07-14 | |
| US201562197966P | 2015-07-28 | 2015-07-28 | |
| US201662277201P | 2016-01-11 | 2016-01-11 | |
| PCT/US2016/042074 WO2017011544A1 (en) | 2015-07-14 | 2016-07-13 | Anti-cd154 antibody having improved binding, functional and safety characteristics and use in human immunotherapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018000548A true MX2018000548A (es) | 2018-09-26 |
Family
ID=57757587
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018000548A MX2018000548A (es) | 2015-07-14 | 2016-07-13 | Anticuerpo anti-cd154 con características de unión, funcionalidad y seguridad mejoradas y uso en inmunoterapia humana. |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US10874738B2 (es) |
| EP (1) | EP3331548A4 (es) |
| JP (3) | JP6826113B2 (es) |
| KR (1) | KR20180037984A (es) |
| CN (2) | CN108135969B (es) |
| AU (2) | AU2016294417B2 (es) |
| BR (1) | BR112018000653A2 (es) |
| CA (1) | CA2992116A1 (es) |
| CL (1) | CL2018000103A1 (es) |
| CO (1) | CO2018001363A2 (es) |
| CR (1) | CR20180097A (es) |
| DO (1) | DOP2018000018A (es) |
| EA (1) | EA201890297A1 (es) |
| EC (1) | ECSP18009949A (es) |
| GT (1) | GT201800018A (es) |
| HK (1) | HK1249735A1 (es) |
| IL (3) | IL310460A (es) |
| MX (1) | MX2018000548A (es) |
| MY (1) | MY196991A (es) |
| PE (1) | PE20180741A1 (es) |
| PH (1) | PH12018500098A1 (es) |
| SG (1) | SG10201913431QA (es) |
| TN (1) | TN2018000021A1 (es) |
| WO (1) | WO2017011544A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2018000548A (es) * | 2015-07-14 | 2018-09-26 | Immunext Inc | Anticuerpo anti-cd154 con características de unión, funcionalidad y seguridad mejoradas y uso en inmunoterapia humana. |
| RU2018122255A (ru) | 2015-11-27 | 2019-12-19 | Аблинкс Нв | Полипептиды, ингибирующие cd40l |
| EP3773718A4 (en) | 2018-04-06 | 2022-01-19 | aTyr Pharma, Inc. | COMPOSITIONS AND METHODS WITH ANTI-NRP2 ANTIBODIES |
| WO2020056162A1 (en) * | 2018-09-12 | 2020-03-19 | Oregon Health & Science University | Detecting and/or subtyping circulating hybrid cells that correlate with stage and survival |
| CN112770774A (zh) * | 2018-09-24 | 2021-05-07 | 詹森生物科技公司 | 提供安全施用抗cd154抗体的方法 |
| CN109453383A (zh) * | 2018-11-12 | 2019-03-12 | 陈慧慧 | 免疫检查点的抑制剂在制备治疗青光眼及其他眼部免疫损伤机制相关疾病药物中的应用 |
| CN114173772A (zh) * | 2019-04-12 | 2022-03-11 | 托尼克斯医药控股公司 | Cd40-cd154结合的抑制剂 |
| WO2021067761A1 (en) * | 2019-10-03 | 2021-04-08 | Atyr Pharma, Inc. | Compositions and methods comprising anti-nrp2 antibodies |
| CN113488170B (zh) * | 2021-07-02 | 2023-07-25 | 温州医科大学 | 急性前葡萄膜炎复发风险预测模型构建方法及相关设备 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1127351C (zh) | 1993-09-02 | 2003-11-12 | 达特茅斯学院理事 | 诱导抗原特异性ｔ细胞耐受的方法 |
| US6440418B1 (en) | 1995-11-07 | 2002-08-27 | Idec Pharmaceuticals Corporation | Methods of treating autoimmune diseases with gp39-specific antibodies |
| US6001358A (en) * | 1995-11-07 | 1999-12-14 | Idec Pharmaceuticals Corporation | Humanized antibodies to human gp39, compositions containing thereof |
| US6242195B1 (en) | 1998-04-02 | 2001-06-05 | Genentech, Inc. | Methods for determining binding of an analyte to a receptor |
| US6444018B1 (en) | 1998-06-25 | 2002-09-03 | Xerox Corporation | Phase change ink carrier compositions containing anhydride/amino alcohol-based adducts |
| GB0006398D0 (en) * | 2000-03-16 | 2000-05-03 | Novartis Ag | Organic compounds |
| JP2004532608A (ja) * | 2000-10-13 | 2004-10-28 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | ヒト化抗ＬＴ−β−Ｒ抗体 |
| US8388955B2 (en) | 2003-03-03 | 2013-03-05 | Xencor, Inc. | Fc variants |
| WO2005003175A2 (en) * | 2003-06-13 | 2005-01-13 | Biogen Idec Ma Inc. | Aglycosyl anti-cd154 (cd40 ligand) antibodies and uses thereof |
| AU2004266159A1 (en) | 2003-08-22 | 2005-03-03 | Biogen Idec Ma Inc. | Improved antibodies having altered effector function and methods for making the same |
| US20110123440A1 (en) | 2005-03-29 | 2011-05-26 | Genevieve Hansen | Altered Antibody FC Regions and Uses Thereof |
| PL2125894T3 (pl) * | 2007-03-22 | 2019-08-30 | Biogen Ma Inc. | Białka wiążące, w tym przeciwciała, pochodne przeciwciał i fragmenty przeciwciał, które swoiście wiążą się z CD154 i ich zastosowania |
| WO2012138768A2 (en) * | 2011-04-04 | 2012-10-11 | Trustees Of Dartmouth College | Anti-cd154 antibodies having impaired fcr binding and/or complement binding properties and the use thereof in immune therapies |
| US9321833B2 (en) * | 2011-04-04 | 2016-04-26 | The Trustees Of Dartmouth College | Methods of therapy with anti-CD154 antibodies having impaired FcR binding and/or complement binding properties |
| MX2018000548A (es) * | 2015-07-14 | 2018-09-26 | Immunext Inc | Anticuerpo anti-cd154 con características de unión, funcionalidad y seguridad mejoradas y uso en inmunoterapia humana. |
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2016
- 2016-07-13 MX MX2018000548A patent/MX2018000548A/es unknown
- 2016-07-13 US US15/744,379 patent/US10874738B2/en active Active
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