SG10201913431QA - Anti-cd154 antibody having improved binding, functional and safety characteristics and use in human immunotherapy - Google Patents
Anti-cd154 antibody having improved binding, functional and safety characteristics and use in human immunotherapyInfo
- Publication number
- SG10201913431QA SG10201913431QA SG10201913431QA SG10201913431QA SG10201913431QA SG 10201913431Q A SG10201913431Q A SG 10201913431QA SG 10201913431Q A SG10201913431Q A SG 10201913431QA SG 10201913431Q A SG10201913431Q A SG 10201913431QA SG 10201913431Q A SG10201913431Q A SG 10201913431QA
- Authority
- SG
- Singapore
- Prior art keywords
- antibody
- functional
- improved binding
- safety characteristics
- human immunotherapy
- Prior art date
Links
- 238000009169 immunotherapy Methods 0.000 title 1
Classifications
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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-
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Urology & Nephrology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562192269P | 2015-07-14 | 2015-07-14 | |
| US201562197966P | 2015-07-28 | 2015-07-28 | |
| US201662277201P | 2016-01-11 | 2016-01-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201913431QA true SG10201913431QA (en) | 2020-03-30 |
Family
ID=57757587
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201913431QA SG10201913431QA (en) | 2015-07-14 | 2016-07-13 | Anti-cd154 antibody having improved binding, functional and safety characteristics and use in human immunotherapy |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US10874738B2 (en) |
| EP (1) | EP3331548A4 (en) |
| JP (3) | JP6826113B2 (en) |
| KR (1) | KR20180037984A (en) |
| CN (2) | CN108135969B (en) |
| AU (2) | AU2016294417B2 (en) |
| BR (1) | BR112018000653A2 (en) |
| CA (1) | CA2992116A1 (en) |
| CL (1) | CL2018000103A1 (en) |
| CO (1) | CO2018001363A2 (en) |
| CR (1) | CR20180097A (en) |
| DO (1) | DOP2018000018A (en) |
| EA (1) | EA201890297A1 (en) |
| EC (1) | ECSP18009949A (en) |
| GT (1) | GT201800018A (en) |
| HK (1) | HK1249735A1 (en) |
| IL (3) | IL310460A (en) |
| MX (1) | MX2018000548A (en) |
| MY (1) | MY196991A (en) |
| PE (1) | PE20180741A1 (en) |
| PH (1) | PH12018500098A1 (en) |
| SG (1) | SG10201913431QA (en) |
| TN (1) | TN2018000021A1 (en) |
| WO (1) | WO2017011544A1 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2018000548A (en) * | 2015-07-14 | 2018-09-26 | Immunext Inc | Anti-cd154 antibody having improved binding, functional and safety characteristics and use in human immunotherapy. |
| RU2018122255A (en) | 2015-11-27 | 2019-12-19 | Аблинкс Нв | CD40L INHIBITING POLYPEPTIDES |
| EP3773718A4 (en) | 2018-04-06 | 2022-01-19 | aTyr Pharma, Inc. | Compositions and methods comprising anti-nrp2 antibodies |
| WO2020056162A1 (en) * | 2018-09-12 | 2020-03-19 | Oregon Health & Science University | Detecting and/or subtyping circulating hybrid cells that correlate with stage and survival |
| CN112770774A (en) * | 2018-09-24 | 2021-05-07 | 詹森生物科技公司 | Methods for providing safe administration of anti-CD 154 antibodies |
| CN109453383A (en) * | 2018-11-12 | 2019-03-12 | 陈慧慧 | Application of the inhibitor of immunologic test point in preparation treatment glaucoma and other ocular immune damage mechanisms related disease drugs |
| CN114173772A (en) * | 2019-04-12 | 2022-03-11 | 托尼克斯医药控股公司 | Inhibitors of CD40-CD154 binding |
| WO2021067761A1 (en) * | 2019-10-03 | 2021-04-08 | Atyr Pharma, Inc. | Compositions and methods comprising anti-nrp2 antibodies |
| CN113488170B (en) * | 2021-07-02 | 2023-07-25 | 温州医科大学 | Method for constructing acute pre-uveitis recurrence risk prediction model and related equipment |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1127351C (en) | 1993-09-02 | 2003-11-12 | 达特茅斯学院理事 | Method for inducing antigen-specific T cell tolerance |
| US6440418B1 (en) | 1995-11-07 | 2002-08-27 | Idec Pharmaceuticals Corporation | Methods of treating autoimmune diseases with gp39-specific antibodies |
| US6001358A (en) * | 1995-11-07 | 1999-12-14 | Idec Pharmaceuticals Corporation | Humanized antibodies to human gp39, compositions containing thereof |
| US6242195B1 (en) | 1998-04-02 | 2001-06-05 | Genentech, Inc. | Methods for determining binding of an analyte to a receptor |
| US6444018B1 (en) | 1998-06-25 | 2002-09-03 | Xerox Corporation | Phase change ink carrier compositions containing anhydride/amino alcohol-based adducts |
| GB0006398D0 (en) * | 2000-03-16 | 2000-05-03 | Novartis Ag | Organic compounds |
| JP2004532608A (en) * | 2000-10-13 | 2004-10-28 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | Humanized anti-LT-β-R antibody |
| US8388955B2 (en) | 2003-03-03 | 2013-03-05 | Xencor, Inc. | Fc variants |
| WO2005003175A2 (en) * | 2003-06-13 | 2005-01-13 | Biogen Idec Ma Inc. | Aglycosyl anti-cd154 (cd40 ligand) antibodies and uses thereof |
| AU2004266159A1 (en) | 2003-08-22 | 2005-03-03 | Biogen Idec Ma Inc. | Improved antibodies having altered effector function and methods for making the same |
| US20110123440A1 (en) | 2005-03-29 | 2011-05-26 | Genevieve Hansen | Altered Antibody FC Regions and Uses Thereof |
| PL2125894T3 (en) * | 2007-03-22 | 2019-08-30 | Biogen Ma Inc. | Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind cd154 and uses thereof |
| WO2012138768A2 (en) * | 2011-04-04 | 2012-10-11 | Trustees Of Dartmouth College | Anti-cd154 antibodies having impaired fcr binding and/or complement binding properties and the use thereof in immune therapies |
| US9321833B2 (en) * | 2011-04-04 | 2016-04-26 | The Trustees Of Dartmouth College | Methods of therapy with anti-CD154 antibodies having impaired FcR binding and/or complement binding properties |
| MX2018000548A (en) * | 2015-07-14 | 2018-09-26 | Immunext Inc | Anti-cd154 antibody having improved binding, functional and safety characteristics and use in human immunotherapy. |
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2016
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2018
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- 2018-01-12 CL CL2018000103A patent/CL2018000103A1/en unknown
- 2018-02-09 EC ECIEPI20189949A patent/ECSP18009949A/en unknown
- 2018-02-12 CO CONC2018/0001363A patent/CO2018001363A2/en unknown
- 2018-07-17 HK HK18109202.5A patent/HK1249735A1/en unknown
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2020
- 2020-11-23 US US17/101,139 patent/US11596689B2/en active Active
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2021
- 2021-01-13 JP JP2021003152A patent/JP2021063129A/en active Pending
-
2022
- 2022-11-02 AU AU2022263520A patent/AU2022263520A1/en active Pending
-
2023
- 2023-02-01 US US18/162,769 patent/US20240000929A1/en active Pending
- 2023-07-05 JP JP2023110414A patent/JP2023123812A/en active Pending
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