PE20151894A1 - Composiciones y metodos de variantes de inhibidor tisular de la metaloproteinasa tipo tres (timp 3) - Google Patents
Composiciones y metodos de variantes de inhibidor tisular de la metaloproteinasa tipo tres (timp 3)Info
- Publication number
- PE20151894A1 PE20151894A1 PE2015002011A PE2015002011A PE20151894A1 PE 20151894 A1 PE20151894 A1 PE 20151894A1 PE 2015002011 A PE2015002011 A PE 2015002011A PE 2015002011 A PE2015002011 A PE 2015002011A PE 20151894 A1 PE20151894 A1 PE 20151894A1
- Authority
- PE
- Peru
- Prior art keywords
- timp
- methods
- metaloproteinase
- compositions
- type
- Prior art date
Links
- 102000005406 Tissue Inhibitor of Metalloproteinase-3 Human genes 0.000 title abstract 2
- 108010031429 Tissue Inhibitor of Metalloproteinase-3 Proteins 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Se describen muteinas TIMP-3, variantes y derivados, los acidos nucleicos que las codifican, y los metodos de fabricacion y uso de ellos
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361782613P | 2013-03-14 | 2013-03-14 | |
US201361798160P | 2013-03-15 | 2013-03-15 | |
US201361802988P | 2013-03-18 | 2013-03-18 | |
US201461940673P | 2014-02-17 | 2014-02-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20151894A1 true PE20151894A1 (es) | 2016-01-08 |
Family
ID=50473803
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2015002011A PE20151894A1 (es) | 2013-03-14 | 2014-03-13 | Composiciones y metodos de variantes de inhibidor tisular de la metaloproteinasa tipo tres (timp 3) |
Country Status (21)
Country | Link |
---|---|
US (3) | US10189890B2 (es) |
EP (1) | EP2970407B1 (es) |
JP (4) | JP2016513666A (es) |
KR (1) | KR102258564B1 (es) |
CN (2) | CN105531285B (es) |
AP (1) | AP2015008729A0 (es) |
AU (5) | AU2014236683B2 (es) |
BR (1) | BR112015022491A2 (es) |
CA (1) | CA2906053C (es) |
CL (1) | CL2015002663A1 (es) |
EA (1) | EA034200B1 (es) |
HK (1) | HK1219959A1 (es) |
IL (1) | IL241246B (es) |
MX (1) | MX2015012891A (es) |
PE (1) | PE20151894A1 (es) |
PH (1) | PH12015502059A1 (es) |
SG (2) | SG11201507524TA (es) |
TN (1) | TN2015000423A1 (es) |
TW (3) | TW201726725A (es) |
WO (1) | WO2014152012A2 (es) |
ZA (2) | ZA201506746B (es) |
Families Citing this family (65)
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JP2016536343A (ja) * | 2013-09-18 | 2016-11-24 | ジェームス・クック・ユニバーシティー | 抗炎症性のタンパク質及び使用方法 |
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EP3575316A1 (en) * | 2014-08-27 | 2019-12-04 | Amgen, Inc | Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods |
MX2021014323A (es) | 2014-10-14 | 2023-02-02 | Amgen Inc | Dispositivo de inyección de fármaco con indicadores visuales y audibles. |
US11357916B2 (en) | 2014-12-19 | 2022-06-14 | Amgen Inc. | Drug delivery device with live button or user interface field |
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IL303449B1 (en) | 2017-03-09 | 2024-04-01 | Amgen Inc | Insertion mechanism for a drug delivery device |
CN114588404A (zh) | 2017-03-28 | 2022-06-07 | 美国安进公司 | 柱塞杆和注射器组件系统以及方法 |
AU2018280054B2 (en) | 2017-06-08 | 2023-07-13 | Amgen Inc. | Syringe assembly for a drug delivery device and method of assembly |
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WO2019014014A1 (en) | 2017-07-14 | 2019-01-17 | Amgen Inc. | NEEDLE INSERTION-RETRACTING SYSTEM HAVING DOUBLE TORSION SPRING SYSTEM |
JP2020527376A (ja) | 2017-07-21 | 2020-09-10 | アムジエン・インコーポレーテツド | 薬物容器のためのガス透過性シーリング部材及び組立方法 |
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US20210346601A1 (en) | 2018-09-24 | 2021-11-11 | Amgen Inc. | Interventional dosing systems and methods |
WO2020068476A1 (en) | 2018-09-28 | 2020-04-02 | Amgen Inc. | Muscle wire escapement activation assembly for a drug delivery device |
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CA3109988A1 (en) | 2018-10-15 | 2020-04-23 | Amgen Inc. | Platform assembly process for drug delivery device |
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US6562596B1 (en) | 1993-10-06 | 2003-05-13 | Amgen Inc. | Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods |
JPH09235300A (ja) * | 1996-02-29 | 1997-09-09 | Fuji Yakuhin Kogyo Kk | ヒトtimp−3及び抗ヒトtimp−3モノクローナル抗体並びにその用途 |
JP5025045B2 (ja) * | 2001-02-02 | 2012-09-12 | マルホ株式会社 | 多硫酸化多糖類によるtimp産生の亢進 |
US8431396B2 (en) * | 2003-03-21 | 2013-04-30 | The Cleveland Clinic Foundation | Anti-angiogenic peptides |
WO2004085617A2 (en) | 2003-03-21 | 2004-10-07 | The Cleveland Clinic Foundation | Timp3 as vegf inhibitor |
US8383158B2 (en) | 2003-04-15 | 2013-02-26 | Abbott Cardiovascular Systems Inc. | Methods and compositions to treat myocardial conditions |
TW200716750A (en) * | 2005-05-12 | 2007-05-01 | Glaxo Group Ltd | Vaccine composition |
CA2617138A1 (en) * | 2005-07-29 | 2007-02-08 | Imperial Innovations Limited | Mutant timp-3 |
EP2811017A2 (en) * | 2008-04-21 | 2014-12-10 | Novo Nordisk Health Care AG | Hyperglycosylated human coagulation factor IX |
JP5971948B2 (ja) * | 2008-12-04 | 2016-08-17 | クルナ・インコーポレーテッド | Vegfに対する天然アンチセンス転写物の抑制による血管内皮増殖因子(vegf)関連疾患の治療 |
EP2459213A1 (en) * | 2009-07-31 | 2012-06-06 | Amgen Inc. | Polypeptides that bind tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods |
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