DK3551633T3 - Substituerede pyrazoloazepin-4-oner og anvendelse deraf som phosphodiesterasehæmmere - Google Patents
Substituerede pyrazoloazepin-4-oner og anvendelse deraf som phosphodiesterasehæmmere Download PDFInfo
- Publication number
- DK3551633T3 DK3551633T3 DK16809388.8T DK16809388T DK3551633T3 DK 3551633 T3 DK3551633 T3 DK 3551633T3 DK 16809388 T DK16809388 T DK 16809388T DK 3551633 T3 DK3551633 T3 DK 3551633T3
- Authority
- DK
- Denmark
- Prior art keywords
- ones
- phosphodiesterase inhibitors
- pyrazoloazepin
- substituted
- substituted pyrazoloazepin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2016/080548 WO2018108230A1 (en) | 2016-12-12 | 2016-12-12 | Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3551633T3 true DK3551633T3 (da) | 2021-06-28 |
Family
ID=57539258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16809388.8T DK3551633T3 (da) | 2016-12-12 | 2016-12-12 | Substituerede pyrazoloazepin-4-oner og anvendelse deraf som phosphodiesterasehæmmere |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10906915B2 (da) |
| EP (1) | EP3551633B1 (da) |
| JP (1) | JP6850886B2 (da) |
| CN (1) | CN110088108B (da) |
| DK (1) | DK3551633T3 (da) |
| ES (1) | ES2875128T3 (da) |
| RU (1) | RU2762279C2 (da) |
| WO (1) | WO2018108230A1 (da) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3551632B1 (en) * | 2016-12-12 | 2024-06-12 | UNION therapeutics A/S | Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors |
| KR102676384B1 (ko) | 2017-06-20 | 2024-06-20 | 유니온 테라퓨틱스 에이/에스 | 1,3-벤조디옥솔 헤테로시클릭 화합물의 제조방법 |
| FI3724196T3 (fi) | 2017-12-15 | 2023-01-31 | Substituoituja atsetidiinidihydrotienopyridiinejä ja niiden käyttö fosfodiesteraasin estäjinä |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2803299B1 (fr) * | 2000-01-05 | 2004-09-17 | Warner Lambert Co | NOUVELLES PYRAZOLO [4,3-e] DIAZEPINES SUBSTITUEES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION |
| US7423031B2 (en) | 2003-05-01 | 2008-09-09 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| AR058071A1 (es) * | 2005-10-03 | 2008-01-23 | Astrazeneca Ab | Derivados de dihidropirazolo (3,4-e)(1,4)diazepina. procesos de obtencion y composiciones farmaceuticas. |
| JP2010510216A (ja) | 2006-11-15 | 2010-04-02 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼのインヒビターとして有用な化合物 |
| NZ578804A (en) * | 2007-02-28 | 2012-04-27 | Leo Pharma As | Spirocyclic phosphodiesterase inhibitors |
| GB0704652D0 (en) | 2007-03-09 | 2007-04-18 | Syngenta Participations Ag | Novel herbicides |
| AR084070A1 (es) * | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
-
2016
- 2016-12-12 DK DK16809388.8T patent/DK3551633T3/da active
- 2016-12-12 JP JP2019531209A patent/JP6850886B2/ja active Active
- 2016-12-12 CN CN201680091502.7A patent/CN110088108B/zh active Active
- 2016-12-12 EP EP16809388.8A patent/EP3551633B1/en active Active
- 2016-12-12 WO PCT/EP2016/080548 patent/WO2018108230A1/en active Application Filing
- 2016-12-12 US US16/468,420 patent/US10906915B2/en active Active
- 2016-12-12 RU RU2019121006A patent/RU2762279C2/ru active
- 2016-12-12 ES ES16809388T patent/ES2875128T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2019121006A (ru) | 2021-01-12 |
| ES2875128T3 (es) | 2021-11-08 |
| US20200010477A1 (en) | 2020-01-09 |
| JP6850886B2 (ja) | 2021-03-31 |
| CN110088108B (zh) | 2024-06-14 |
| JP2020500920A (ja) | 2020-01-16 |
| CN110088108A (zh) | 2019-08-02 |
| RU2019121006A3 (da) | 2021-01-12 |
| WO2018108230A1 (en) | 2018-06-21 |
| EP3551633B1 (en) | 2021-03-31 |
| EP3551633A1 (en) | 2019-10-16 |
| RU2762279C2 (ru) | 2021-12-17 |
| US10906915B2 (en) | 2021-02-02 |
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