PE20110593A1 - Anticuerpos multiespecificos - Google Patents
Anticuerpos multiespecificosInfo
- Publication number
- PE20110593A1 PE20110593A1 PE2011000442A PE2011000442A PE20110593A1 PE 20110593 A1 PE20110593 A1 PE 20110593A1 PE 2011000442 A PE2011000442 A PE 2011000442A PE 2011000442 A PE2011000442 A PE 2011000442A PE 20110593 A1 PE20110593 A1 PE 20110593A1
- Authority
- PE
- Peru
- Prior art keywords
- hvr
- sequence
- antibody
- seq
- referred
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
- C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
REFERIDA A UN ANTICUERPO AISLADO QUE COMPRENDE UNA SECUENCIA DE REGION HIPERVARIABLE (HVR) L1 QUE COMPRENDE LA SECUENCIA NIAKTISGY (SEQ ID NO:1), DONDE DICHO ANTICUERPO ENLAZA ESPECIFICAMENTE UN RECEPTOR DE CRECIMIENTO EPIDERMICO HUMANO 2 (HER2) Y UN FACTOR DE CRECIMIENTO ENDOTELIO VASCULAR (VEGF). DICHO ANTICUERPO COMPRENDE ADEMAS, UNA O MAS SECUENCIAS HVR TALES COMO (i) HVR-L2 QUE COMPRENDE UNA SECUENCIA WGSFLY (SEQ ID NO:4) I (ii) HVR-L3 QUE COMPRENDE LA SECUENCIA HYSSPP (SEQ ID NO:3). TAMBIEN ESTA REFERIDA A UN POLINUCLEOTIDO QUE CODIFICA UN ANTICUERPO, UN POLIPEPTIDO, UN VECTOR Y UNA CELULA HUESPED
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19085608P | 2008-09-03 | 2008-09-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20110593A1 true PE20110593A1 (es) | 2011-09-10 |
Family
ID=41399375
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2014002488A PE20150222A1 (es) | 2008-09-03 | 2009-09-01 | Anticuerpos multiespecificos |
PE2011000442A PE20110593A1 (es) | 2008-09-03 | 2009-09-01 | Anticuerpos multiespecificos |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2014002488A PE20150222A1 (es) | 2008-09-03 | 2009-09-01 | Anticuerpos multiespecificos |
Country Status (19)
Country | Link |
---|---|
US (3) | US8193321B2 (es) |
EP (1) | EP2324061B1 (es) |
JP (1) | JP5796831B2 (es) |
KR (1) | KR101705911B1 (es) |
CN (1) | CN102143977B (es) |
AR (1) | AR073538A1 (es) |
AU (1) | AU2009288167B2 (es) |
BR (1) | BRPI0918648A2 (es) |
CA (1) | CA2734905A1 (es) |
ES (1) | ES2628108T3 (es) |
IL (1) | IL211349A0 (es) |
MX (1) | MX353984B (es) |
PE (2) | PE20150222A1 (es) |
PH (1) | PH12013502230A1 (es) |
RU (1) | RU2547596C2 (es) |
SG (1) | SG193851A1 (es) |
TW (1) | TWI487712B (es) |
WO (1) | WO2010027981A1 (es) |
ZA (1) | ZA201101970B (es) |
Families Citing this family (33)
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US20050106667A1 (en) * | 2003-08-01 | 2005-05-19 | Genentech, Inc | Binding polypeptides with restricted diversity sequences |
US7758859B2 (en) * | 2003-08-01 | 2010-07-20 | Genentech, Inc. | Anti-VEGF antibodies |
US10118970B2 (en) | 2006-08-30 | 2018-11-06 | Genentech, Inc. | Multispecific antibodies |
JP5796831B2 (ja) | 2008-09-03 | 2015-10-21 | ジェネンテック, インコーポレイテッド | 多重特異性抗体 |
US8268314B2 (en) | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
EP2575880B1 (en) | 2010-05-27 | 2019-01-16 | Genmab A/S | Monoclonal antibodies against her2 epitope |
EP3539988A3 (en) | 2010-05-27 | 2019-12-04 | Genmab A/S | Monoclonal antibodies against her2 |
CN103443124A (zh) * | 2011-01-17 | 2013-12-11 | 诺沃—诺迪斯克有限公司 | Il-21配体 |
US9527925B2 (en) | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
AU2012245116A1 (en) | 2011-04-20 | 2013-11-07 | Genmab A/S | Bispecific antibodies against HER2 and CD3 |
CN104024432B (zh) | 2011-08-31 | 2017-02-22 | 基因泰克公司 | 诊断性标志物 |
KR101453516B1 (ko) | 2011-09-20 | 2014-10-24 | 가톨릭대학교 산학협력단 | 항-vegf 항체를 포함하는 자가면역질환 예방 및 치료용 조성물 |
JP2014531213A (ja) | 2011-09-30 | 2014-11-27 | ジェネンテック, インコーポレイテッド | 上皮又は間葉の表現型の診断用メチル化マーカー、及び腫瘍又は腫瘍細胞におけるegfrキナーゼ阻害薬に対する応答 |
US11142563B2 (en) | 2012-06-14 | 2021-10-12 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule containing modified Fc region |
HRP20211641T1 (hr) | 2012-07-13 | 2022-02-04 | Roche Glycart Ag | Bispecifična protutijela anti-vegf/anti-ang-2 i njihova primjena u liječenju vaskularnih očnih bolesti |
WO2014134169A1 (en) * | 2013-02-26 | 2014-09-04 | Senex Biotechnology, Inc. | Inhibitors of cdk8/19 for use in treating estrogen receptor positive breast cancer |
CN113278076A (zh) * | 2013-11-11 | 2021-08-20 | 中外制药株式会社 | 含有改变了抗体可变区的抗原结合分子 |
JP2015097496A (ja) * | 2013-11-19 | 2015-05-28 | 国立大学法人 東京大学 | Robo1に対する親和性を向上させた抗体及び高親和性抗体の分子設計方法 |
WO2015119841A1 (en) * | 2014-02-05 | 2015-08-13 | Merck Sharp & Dohme Corp. | Role of il-23 and pd-1 in autoreactive immune response |
GB201411420D0 (en) * | 2014-06-26 | 2014-08-13 | Ucb Biopharma Sprl | Antibody constructs |
US10526391B2 (en) | 2014-07-22 | 2020-01-07 | The University Of Notre Dame Du Lac | Molecular constructs and uses thereof |
JP6897952B2 (ja) * | 2014-09-16 | 2021-07-07 | 国立大学法人東京海洋大学 | 濃縮された生着能をもつ未分化生殖細胞を用いた生殖細胞系列への分化誘導方法 |
KR102390359B1 (ko) | 2014-09-29 | 2022-04-22 | 삼성전자주식회사 | 폴리펩타이드, 이를 포함하는 항 VEGF 항체 및 항 c-Met/항 VEGF 이중 특이 항체 |
US11154615B2 (en) | 2014-11-11 | 2021-10-26 | Chugai Seiyaku Kabushiki Kaisha | Library of antigen-binding molecules including modified antibody variable region |
AU2016312259B2 (en) | 2015-08-26 | 2018-12-06 | Bison Therapeutics Inc. | Multispecific antibody platform and related methods |
CN116987187A (zh) | 2015-09-23 | 2023-11-03 | 豪夫迈·罗氏有限公司 | 抗-vegf抗体的优化的变体 |
GB201521447D0 (en) * | 2015-12-04 | 2016-01-20 | Ucb Biopharma Sprl | De novo antibody design |
MA46681A (fr) * | 2016-01-28 | 2019-09-11 | Janssen Biotech Inc | Anticorps bispécifiques anti-tnf-alpha/il-17a antibodies et anticorps anti-tnf-alpha et leurs procédés d'utilisation |
EP3634999A1 (en) * | 2017-06-07 | 2020-04-15 | Philogen S.p.A. | Vascular endothelial growth factor/anti-fibronectin antibody fusion proteins |
CN107602702A (zh) * | 2017-09-22 | 2018-01-19 | 生标(上海)医疗器械科技有限公司 | 一种同时靶向人p185和血管内皮生长因子的抗体及其应用 |
JP7357616B2 (ja) | 2017-12-05 | 2023-10-06 | 中外製薬株式会社 | Cd3およびcd137に結合する改変された抗体可変領域を含む抗原結合分子 |
CN110850068B (zh) * | 2018-08-21 | 2023-08-15 | 上海恒润达生生物科技股份有限公司 | 一种嵌合抗原受体亲和力检测方法 |
CN115397866A (zh) | 2020-03-31 | 2022-11-25 | 中外制药株式会社 | 靶向dll3的多特异性抗原结合分子及其用途 |
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KR101710472B1 (ko) * | 2007-11-30 | 2017-02-27 | 글락소 그룹 리미티드 | 항원-결합 작제물 |
JP5796831B2 (ja) | 2008-09-03 | 2015-10-21 | ジェネンテック, インコーポレイテッド | 多重特異性抗体 |
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2009
- 2009-09-01 JP JP2011526137A patent/JP5796831B2/ja not_active Expired - Fee Related
- 2009-09-01 US US12/552,177 patent/US8193321B2/en not_active Expired - Fee Related
- 2009-09-01 KR KR1020117007567A patent/KR101705911B1/ko active IP Right Grant
- 2009-09-01 PE PE2014002488A patent/PE20150222A1/es not_active Application Discontinuation
- 2009-09-01 MX MX2011002389A patent/MX353984B/es active IP Right Grant
- 2009-09-01 WO PCT/US2009/055625 patent/WO2010027981A1/en active Application Filing
- 2009-09-01 ES ES09792139T patent/ES2628108T3/es active Active
- 2009-09-01 RU RU2011112324/10A patent/RU2547596C2/ru not_active IP Right Cessation
- 2009-09-01 EP EP09792139.9A patent/EP2324061B1/en not_active Not-in-force
- 2009-09-01 TW TW098129415A patent/TWI487712B/zh not_active IP Right Cessation
- 2009-09-01 SG SG2013066501A patent/SG193851A1/en unknown
- 2009-09-01 AU AU2009288167A patent/AU2009288167B2/en not_active Ceased
- 2009-09-01 AR ARP090103347A patent/AR073538A1/es unknown
- 2009-09-01 BR BRPI0918648A patent/BRPI0918648A2/pt not_active IP Right Cessation
- 2009-09-01 CN CN200980134512.4A patent/CN102143977B/zh not_active Expired - Fee Related
- 2009-09-01 CA CA2734905A patent/CA2734905A1/en not_active Abandoned
- 2009-09-01 PE PE2011000442A patent/PE20110593A1/es not_active Application Discontinuation
-
2011
- 2011-02-18 US US13/030,760 patent/US9017686B2/en not_active Expired - Fee Related
- 2011-02-22 IL IL211349A patent/IL211349A0/en not_active IP Right Cessation
- 2011-03-15 ZA ZA2011/01970A patent/ZA201101970B/en unknown
-
2013
- 2013-10-30 PH PH12013502230A patent/PH12013502230A1/en unknown
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2015
- 2015-03-23 US US14/665,697 patent/US9522960B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR101705911B1 (ko) | 2017-02-10 |
MX2011002389A (es) | 2011-05-23 |
TW201011047A (en) | 2010-03-16 |
IL211349A0 (en) | 2011-05-31 |
MX353984B (es) | 2017-11-27 |
JP2012501648A (ja) | 2012-01-26 |
US20150315290A1 (en) | 2015-11-05 |
TWI487712B (zh) | 2015-06-11 |
US20100322946A1 (en) | 2010-12-23 |
AR073538A1 (es) | 2010-11-17 |
EP2324061A1 (en) | 2011-05-25 |
WO2010027981A1 (en) | 2010-03-11 |
KR20110081812A (ko) | 2011-07-14 |
ZA201101970B (en) | 2012-05-30 |
PH12013502230A1 (en) | 2016-01-25 |
PE20150222A1 (es) | 2015-03-02 |
AU2009288167A1 (en) | 2010-03-11 |
US20110142852A1 (en) | 2011-06-16 |
US9522960B2 (en) | 2016-12-20 |
RU2011112324A (ru) | 2012-10-10 |
RU2547596C2 (ru) | 2015-04-10 |
JP5796831B2 (ja) | 2015-10-21 |
SG193851A1 (en) | 2013-10-30 |
EP2324061B1 (en) | 2017-04-12 |
US8193321B2 (en) | 2012-06-05 |
ES2628108T3 (es) | 2017-08-01 |
CN102143977B (zh) | 2014-08-06 |
AU2009288167B2 (en) | 2015-10-22 |
US9017686B2 (en) | 2015-04-28 |
CA2734905A1 (en) | 2010-03-11 |
BRPI0918648A2 (pt) | 2019-09-03 |
CN102143977A (zh) | 2011-08-03 |
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