PE20110434A1 - Compuestos radiomarcados derivados de [5-metanosulfonil-fenil]-[5-(tetrahidro-piran-4-il)-1,3-dihidro-isoindol-2-il]-metanona - Google Patents

Compuestos radiomarcados derivados de [5-metanosulfonil-fenil]-[5-(tetrahidro-piran-4-il)-1,3-dihidro-isoindol-2-il]-metanona

Info

Publication number
PE20110434A1
PE20110434A1 PE2011000892A PE2011000892A PE20110434A1 PE 20110434 A1 PE20110434 A1 PE 20110434A1 PE 2011000892 A PE2011000892 A PE 2011000892A PE 2011000892 A PE2011000892 A PE 2011000892A PE 20110434 A1 PE20110434 A1 PE 20110434A1
Authority
PE
Peru
Prior art keywords
isoindol
methanone
pyran
tetrahydro
dihydro
Prior art date
Application number
PE2011000892A
Other languages
English (en)
Inventor
Daniela Alberati
Edilio Maurizio Borroni
Thomas Hartung
Roger Norcross
Emmanuel Pinard
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20110434A1 publication Critical patent/PE20110434A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS RADIOMARCADOS DE FORMULA (I) DONDE R1 ES ISOPROPOXI O 2,2,2-TRIFLUOR-1-METIL-ETOXI; R2 ES CH3 RADIOMARCADO EN DONDE EL RADIONUCLIDO ES EL H3 O EL C11. SON COMPUESTOS PREFERIDOS: [H3-METIL]-[5-METANOSULFONIL-2-((S)-2,2,2-TRIFLUOR-1-METIL-ETOXI)-FENIL]-[5-(TETRAHIDRO-PIRAN-4-IL)-1,3-DIHIDRO-ISOINDOL-2-IL]-METANONA; [C11-METIL]-[5-METANOSULFONIL-2-((S)-2,2,2-TRIFLUOR-1-METIL-ETOXI)-FENIL]-[5-(TETRAHIDRO-PIRAN-4-IL)-1,3-DIHIDRO-ISOINDOL-2-IL]-METANONA; [H3-METIL]-(2-ISOPROPOXI-5-METANOSULFONIL-FENIL)-[5-(TETRAHIDRO-PIRAN-4-IL)-1,3-DIHIDRO-ISOINDOL-2-IL]-METANONA; [C11-METIL]-(2-ISOPROPOXI-5-METANOSULFONIL-FENIL)-[5-(TETRAHIDRO-PIRAN-4-IL)-1,3-DIHIDRO-ISOINDOL-2-IL]-METANONA. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DEL TRANSPORTADOR DE GLICINA 1 (GlyT1) SIENDO UTILES COMO TRAZADORES PET PARA LA FORMACION DE IMAGENES CON FINES DE DIAGNOSTICO DEL GlyT1 EN EL CEREBRO DE UN MAMIFERO
PE2011000892A 2008-11-04 2009-10-26 Compuestos radiomarcados derivados de [5-metanosulfonil-fenil]-[5-(tetrahidro-piran-4-il)-1,3-dihidro-isoindol-2-il]-metanona PE20110434A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08168229 2008-11-04

Publications (1)

Publication Number Publication Date
PE20110434A1 true PE20110434A1 (es) 2011-07-01

Family

ID=41402176

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011000892A PE20110434A1 (es) 2008-11-04 2009-10-26 Compuestos radiomarcados derivados de [5-metanosulfonil-fenil]-[5-(tetrahidro-piran-4-il)-1,3-dihidro-isoindol-2-il]-metanona

Country Status (21)

Country Link
US (1) US8153679B2 (es)
EP (1) EP2342197B1 (es)
JP (1) JP5543477B2 (es)
KR (1) KR101307671B1 (es)
CN (1) CN102186844B (es)
AR (1) AR074084A1 (es)
AU (1) AU2009312891B2 (es)
BR (1) BRPI0921795B8 (es)
CA (1) CA2739869C (es)
CL (1) CL2011000982A1 (es)
DK (1) DK2342197T3 (es)
ES (1) ES2401221T3 (es)
IL (1) IL211804A (es)
MX (1) MX2011004350A (es)
PE (1) PE20110434A1 (es)
PL (1) PL2342197T3 (es)
RU (1) RU2512529C2 (es)
SI (1) SI2342197T1 (es)
TW (1) TWI449537B (es)
WO (1) WO2010052143A1 (es)
ZA (1) ZA201102521B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5618047B2 (ja) * 2010-01-29 2014-11-05 国立大学法人千葉大学 ポジトロン断層撮影法およびポジトロン放出化合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ME00116B (me) 2003-08-11 2010-10-10 Hoffmann La Roche Piperazin sa ili supstituisanom fenil grupom i njihova upotreba kao inhibitora glyt1
DK1848694T3 (da) * 2005-02-07 2010-01-25 Hoffmann La Roche Heterocykliske substituerede phenylmethanoner som inhibitorer af glycintransporter
WO2007041025A2 (en) * 2005-09-29 2007-04-12 Merck & Co., Inc. Radiolabeled glycine transporter inhibitors

Also Published As

Publication number Publication date
US20100111862A1 (en) 2010-05-06
AR074084A1 (es) 2010-12-22
ES2401221T3 (es) 2013-04-17
KR101307671B1 (ko) 2013-09-12
JP2012507486A (ja) 2012-03-29
IL211804A (en) 2013-11-28
DK2342197T3 (da) 2013-02-18
CL2011000982A1 (es) 2012-02-03
CN102186844A (zh) 2011-09-14
EP2342197B1 (en) 2013-01-16
BRPI0921795B8 (pt) 2021-07-27
TW201019964A (en) 2010-06-01
US8153679B2 (en) 2012-04-10
JP5543477B2 (ja) 2014-07-09
SI2342197T1 (sl) 2013-05-31
EP2342197A1 (en) 2011-07-13
CA2739869C (en) 2016-09-27
PL2342197T3 (pl) 2013-06-28
KR20110063861A (ko) 2011-06-14
CA2739869A1 (en) 2011-05-14
BRPI0921795B1 (pt) 2020-10-20
CN102186844B (zh) 2014-08-13
IL211804A0 (en) 2011-06-30
ZA201102521B (en) 2012-09-29
BRPI0921795A2 (pt) 2016-01-12
WO2010052143A1 (en) 2010-05-14
AU2009312891B2 (en) 2013-07-11
MX2011004350A (es) 2011-05-23
TWI449537B (zh) 2014-08-21
RU2011118230A (ru) 2012-12-20
RU2512529C2 (ru) 2014-04-10
AU2009312891A1 (en) 2010-05-14

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