PE20110394A1 - Virus sincitial respiratorio vivo atenuado - Google Patents
Virus sincitial respiratorio vivo atenuadoInfo
- Publication number
- PE20110394A1 PE20110394A1 PE2011000971A PE2011000971A PE20110394A1 PE 20110394 A1 PE20110394 A1 PE 20110394A1 PE 2011000971 A PE2011000971 A PE 2011000971A PE 2011000971 A PE2011000971 A PE 2011000971A PE 20110394 A1 PE20110394 A1 PE 20110394A1
- Authority
- PE
- Peru
- Prior art keywords
- protein coded
- gen
- gene
- protein
- glutamic acid
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 3
- 230000002238 attenuated effect Effects 0.000 title abstract 3
- 230000000241 respiratory effect Effects 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 17
- 235000018102 proteins Nutrition 0.000 abstract 12
- 102000004169 proteins and genes Human genes 0.000 abstract 12
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical group NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 6
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 3
- 235000013922 glutamic acid Nutrition 0.000 abstract 3
- 239000004220 glutamic acid Substances 0.000 abstract 3
- 239000004471 Glycine Substances 0.000 abstract 2
- 125000003412 L-alanyl group Chemical group [H]N([H])[C@@](C([H])([H])[H])(C(=O)[*])[H] 0.000 abstract 2
- 235000004279 alanine Nutrition 0.000 abstract 2
- RMZNXRYIFGTWPF-UHFFFAOYSA-N 2-nitrosoacetic acid Chemical compound OC(=O)CN=O RMZNXRYIFGTWPF-UHFFFAOYSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical group NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical group OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/115—Paramyxoviridae, e.g. parainfluenza virus
- C07K14/135—Respiratory syncytial virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/544—Mucosal route to the airways
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18561—Methods of inactivation or attenuation
- C12N2760/18564—Methods of inactivation or attenuation by serial passage
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19832708P | 2008-11-05 | 2008-11-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20110394A1 true PE20110394A1 (es) | 2011-06-22 |
Family
ID=41527812
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2011000971A PE20110394A1 (es) | 2008-11-05 | 2009-11-03 | Virus sincitial respiratorio vivo atenuado |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9011876B2 (https=) |
| EP (1) | EP2346990B1 (https=) |
| JP (2) | JP5016731B2 (https=) |
| KR (1) | KR20110063863A (https=) |
| CN (1) | CN102272295A (https=) |
| AU (1) | AU2009311287C1 (https=) |
| BR (1) | BRPI0921424A2 (https=) |
| CA (1) | CA2742086A1 (https=) |
| CL (1) | CL2011000999A1 (https=) |
| CO (1) | CO6362047A2 (https=) |
| EC (1) | ECSP11011033A (https=) |
| IL (1) | IL212437A0 (https=) |
| MA (1) | MA32878B1 (https=) |
| MX (1) | MX2011004719A (https=) |
| PE (1) | PE20110394A1 (https=) |
| RU (1) | RU2011122615A (https=) |
| TN (1) | TN2011000182A1 (https=) |
| WO (1) | WO2010053883A1 (https=) |
| ZA (1) | ZA201103259B (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2742086A1 (en) * | 2008-11-05 | 2010-05-14 | Merck Sharp & Dohme Corp. | Live, attenuated respiratory syncytial virus |
| EP2744894A4 (en) * | 2011-08-18 | 2015-04-22 | Ycine Llc | PRODUCTION OF INFECTIOUS RNA VIRUSES IN YEAST |
| WO2013031827A1 (ja) | 2011-08-29 | 2013-03-07 | 国立大学法人徳島大学 | Rsv粘膜ワクチン |
| US9957486B2 (en) | 2013-02-08 | 2018-05-01 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | Attenuation of human respiratory syncytial virus by genome scale codon-pair deoptimization |
| CN113322264B (zh) * | 2013-03-14 | 2024-05-31 | 爱默蕾大学 | 具有沉默突变的重组rsv、其相关疫苗和方法 |
| CA2926696A1 (en) | 2013-10-16 | 2015-04-23 | Merck Sharp & Dohme Corp | Thermostable respiratory synctial virus (rsv) vaccine compositions |
| WO2015057540A1 (en) | 2013-10-16 | 2015-04-23 | Merck Sharp & Dohme Corp. | Method of microwave vacuum drying spherical-shaped pellets of biological materials |
| US10947512B2 (en) * | 2015-08-14 | 2021-03-16 | Research Institute At Nationwide Children's Hospital | Respiratory syncytial virus having altered NS1 protein function and related materials and methods |
| MX2018005462A (es) | 2015-10-29 | 2018-08-01 | Univ Emory | Composiciones inmunogénicas de rsv quimérico y métodos de uso. |
| EP3515930A1 (en) | 2016-09-23 | 2019-07-31 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Vaccine candidates for human respiratory syncytial virus (rsv) having attenuated phenotypes |
| TWI761453B (zh) | 2017-03-01 | 2022-04-21 | 英商梅迪繆思有限公司 | 抗rsv單株抗體配製物 |
| WO2019055768A1 (en) * | 2017-09-15 | 2019-03-21 | Ohio State Innovation Foundation | VACCINES AND METHODS OF MAKING AND USING VACCINES FOR THE PREVENTION OF SYNCYTIAL RESPIRATORY VIRUS (RSV) INFECTIONS |
| TW202535439A (zh) * | 2023-11-17 | 2025-09-16 | 美商賽諾菲巴斯德公司 | 海藻糖疫苗調配物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0917592A4 (en) * | 1996-04-04 | 2002-04-24 | Univ Michigan | REDUCED RSV |
| JP2002507408A (ja) | 1998-03-26 | 2002-03-12 | アメリカン・サイアナミド・カンパニー | 麻疹ウイルスもしくはヒト呼吸合胞体ウイルスサブグループｂの弱毒化の原因である突然変異 |
| CN100354425C (zh) | 1999-07-09 | 2007-12-12 | 美国政府健康及人类服务部 | 减毒的人－牛嵌合呼吸道合胞病毒疫苗的生产 |
| AU2003295339B2 (en) | 2002-09-27 | 2009-03-26 | Medimmune, Llc | Functional mutations in respiratory syncytial virus |
| CA2520671C (en) * | 2003-03-28 | 2014-03-18 | Medimmune Vaccines, Inc. | Compositions and methods involving respiratory syncytial virus subgroup b strain 9320 |
| JPWO2008096811A1 (ja) * | 2007-02-07 | 2010-05-27 | ディナベック株式会社 | 弱毒化マイナス鎖ｒｎａウイルス |
| CA2742086A1 (en) * | 2008-11-05 | 2010-05-14 | Merck Sharp & Dohme Corp. | Live, attenuated respiratory syncytial virus |
-
2009
- 2009-11-03 CA CA2742086A patent/CA2742086A1/en not_active Abandoned
- 2009-11-03 EP EP09748199.8A patent/EP2346990B1/en active Active
- 2009-11-03 US US13/127,647 patent/US9011876B2/en active Active
- 2009-11-03 CN CN2009801537266A patent/CN102272295A/zh active Pending
- 2009-11-03 MX MX2011004719A patent/MX2011004719A/es unknown
- 2009-11-03 JP JP2011534864A patent/JP5016731B2/ja not_active Expired - Fee Related
- 2009-11-03 AU AU2009311287A patent/AU2009311287C1/en not_active Ceased
- 2009-11-03 PE PE2011000971A patent/PE20110394A1/es not_active Application Discontinuation
- 2009-11-03 BR BRPI0921424A patent/BRPI0921424A2/pt not_active IP Right Cessation
- 2009-11-03 WO PCT/US2009/063024 patent/WO2010053883A1/en not_active Ceased
- 2009-11-03 RU RU2011122615/10A patent/RU2011122615A/ru not_active Application Discontinuation
- 2009-11-03 KR KR1020117010304A patent/KR20110063863A/ko not_active Ceased
-
2011
- 2011-04-17 IL IL212437A patent/IL212437A0/en unknown
- 2011-04-19 TN TN2011000182A patent/TN2011000182A1/fr unknown
- 2011-05-04 CL CL2011000999A patent/CL2011000999A1/es unknown
- 2011-05-05 EC EC2011011033A patent/ECSP11011033A/es unknown
- 2011-05-05 ZA ZA2011/03259A patent/ZA201103259B/en unknown
- 2011-05-12 CO CO11058596A patent/CO6362047A2/es not_active Application Discontinuation
- 2011-06-03 MA MA33913A patent/MA32878B1/fr unknown
- 2011-08-05 JP JP2011171459A patent/JP5743794B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009311287C1 (en) | 2015-02-19 |
| EP2346990A1 (en) | 2011-07-27 |
| ZA201103259B (en) | 2012-01-25 |
| US9011876B2 (en) | 2015-04-21 |
| CA2742086A1 (en) | 2010-05-14 |
| CN102272295A (zh) | 2011-12-07 |
| EP2346990B1 (en) | 2016-01-06 |
| IL212437A0 (en) | 2011-06-30 |
| ECSP11011033A (es) | 2011-12-30 |
| WO2010053883A1 (en) | 2010-05-14 |
| JP2012507302A (ja) | 2012-03-29 |
| CL2011000999A1 (es) | 2012-07-20 |
| RU2011122615A (ru) | 2012-12-20 |
| BRPI0921424A2 (pt) | 2016-01-05 |
| JP5743794B2 (ja) | 2015-07-01 |
| JP5016731B2 (ja) | 2012-09-05 |
| TN2011000182A1 (en) | 2012-12-17 |
| AU2009311287B2 (en) | 2013-02-07 |
| AU2009311287A1 (en) | 2010-05-14 |
| KR20110063863A (ko) | 2011-06-14 |
| MX2011004719A (es) | 2011-05-31 |
| JP2011250798A (ja) | 2011-12-15 |
| CO6362047A2 (es) | 2012-01-20 |
| MA32878B1 (fr) | 2011-12-01 |
| US20110212130A1 (en) | 2011-09-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |