PE20091566A1 - (R)-N*6*-ETIL-6,7-DIHIDRO-5H-INDENO[5,6-d]TIAZOL-2,6-DIAMINA Y SUS SALES Y UN PROCEDIMIENTO PARA SU PREPARACION - Google Patents

(R)-N*6*-ETIL-6,7-DIHIDRO-5H-INDENO[5,6-d]TIAZOL-2,6-DIAMINA Y SUS SALES Y UN PROCEDIMIENTO PARA SU PREPARACION

Info

Publication number
PE20091566A1
PE20091566A1 PE2009000253A PE2009000253A PE20091566A1 PE 20091566 A1 PE20091566 A1 PE 20091566A1 PE 2009000253 A PE2009000253 A PE 2009000253A PE 2009000253 A PE2009000253 A PE 2009000253A PE 20091566 A1 PE20091566 A1 PE 20091566A1
Authority
PE
Peru
Prior art keywords
thiazol
indene
dihydro
compound
diamine
Prior art date
Application number
PE2009000253A
Other languages
English (en)
Inventor
William C Blackwell Iii
James Hulsizer
Jianwei Liu
Gary Steelman
Rebecca Urbanek
Dan Widzowski
Yen Wu
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20091566A1 publication Critical patent/PE20091566A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) (R)-N*6*-ETIL-6,7-DIHIDRO-5H-INDENO[5,6-d]TIAZOL-2,6-DIAMINA Y A UN PROCEDIMIENTO PARA PREPARAR DICHO COMPUESTO QUE COMPRENDE: A) REACCIONAR N-((R)-6-ETILAMINO-6,7-DIHIDRO-5H-INDENO[5,6-d]TIAZOL-2-IL)-BENZAMIDA.2HBr CON ACIDO BROMHIDRICO EN CALENTAMIENTO A REFLUJO PARA OBTENER (R)-N*6*-ETIL-6,7-DIHIDRO-5H-INDENO[5,6-d]TIAZOL-2,6-DIAMINA.2HBr; B) DISOLVER EL COMPUESTO OBTENIDO (R)-N*6*-ETIL-6,7-DIHIDRO-5H-INDENO[5,6-d]TIAZOL-2,6-DIAMINA.2HBr EN AGUA Y ANADIR LA BASE NaOH ACUOSO PARA PRECIPITAR EL COMPUESTO DE FORMULA (I); Y C) FILTRAR Y LAVAR CON AGUA EL COMPUESTO (I) OBTENIDO HASTA UN pH DE 6,5. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UN AGONISTA PARCIAL DE LOS RECEPTORES D2 DE DOPAMINA SIENDO UTIL EN EL TRATAMIENTO DE ESQUIZOFRENIA, ENFERMEDAD DE PARKINSON, SINDROME DE TOURETTE
PE2009000253A 2008-02-21 2009-02-20 (R)-N*6*-ETIL-6,7-DIHIDRO-5H-INDENO[5,6-d]TIAZOL-2,6-DIAMINA Y SUS SALES Y UN PROCEDIMIENTO PARA SU PREPARACION PE20091566A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3033208P 2008-02-21 2008-02-21

Publications (1)

Publication Number Publication Date
PE20091566A1 true PE20091566A1 (es) 2009-11-06

Family

ID=40985770

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000253A PE20091566A1 (es) 2008-02-21 2009-02-20 (R)-N*6*-ETIL-6,7-DIHIDRO-5H-INDENO[5,6-d]TIAZOL-2,6-DIAMINA Y SUS SALES Y UN PROCEDIMIENTO PARA SU PREPARACION

Country Status (24)

Country Link
US (1) US20090215841A1 (es)
EP (1) EP2254876A4 (es)
JP (1) JP2011512407A (es)
KR (1) KR20100122487A (es)
CN (1) CN101952266A (es)
AR (1) AR070618A1 (es)
AU (1) AU2009215920A1 (es)
BR (1) BRPI0907158A2 (es)
CA (1) CA2716215A1 (es)
CL (1) CL2009000392A1 (es)
CO (1) CO6300849A2 (es)
CR (1) CR11639A (es)
DO (1) DOP2010000257A (es)
EA (1) EA201001095A1 (es)
EC (1) ECSP10010412A (es)
IL (1) IL206817A0 (es)
MX (1) MX2010008923A (es)
NI (1) NI201000141A (es)
PE (1) PE20091566A1 (es)
SA (1) SA109300120B1 (es)
TW (1) TW200940516A (es)
UY (1) UY31668A1 (es)
WO (1) WO2009105026A1 (es)
ZA (1) ZA201004800B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6958797B2 (ja) * 2016-06-21 2021-11-02 浙江柏拉阿図医薬科技有限公司 Ｃ型肝炎ウイルス阻害剤およびその使用
CN109134600B (zh) * 2017-06-19 2021-07-20 杭州国谋生物科技有限公司 作为丙型肝炎抑制剂的烷基及杂环化合物及其在药物中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9802360D0 (sv) * 1998-07-01 1998-07-01 Wikstroem Hakan Vilhelm New 2-aminothiazol-fused 2-aminoindans and 2-aminotetralins ((basic)-N-substituted and (basic)-N,N-disubstituted derivatives of 2,6-diamino-thiazolo(4,5-f)indan and 2,7-di-amino-thiazolo(4,5-g)tetralin
WO2005084205A2 (en) * 2004-02-27 2005-09-15 Teva Pharmaceutical Industries, Ltd. Diamino thiazoloindan derivatives and their use

Also Published As

Publication number Publication date
TW200940516A (en) 2009-10-01
EP2254876A1 (en) 2010-12-01
JP2011512407A (ja) 2011-04-21
BRPI0907158A2 (pt) 2015-07-07
WO2009105026A1 (en) 2009-08-27
AR070618A1 (es) 2010-04-21
EP2254876A4 (en) 2012-10-31
AU2009215920A1 (en) 2009-08-27
NI201000141A (es) 2011-03-24
ECSP10010412A (es) 2010-09-30
CO6300849A2 (es) 2011-07-21
CR11639A (es) 2010-10-05
KR20100122487A (ko) 2010-11-22
ZA201004800B (en) 2012-06-27
EA201001095A1 (ru) 2011-04-29
IL206817A0 (en) 2010-12-30
CL2009000392A1 (es) 2010-09-24
CA2716215A1 (en) 2009-08-27
UY31668A1 (es) 2009-09-30
US20090215841A1 (en) 2009-08-27
CN101952266A (zh) 2011-01-19
SA109300120B1 (ar) 2011-10-08
DOP2010000257A (es) 2010-10-31
MX2010008923A (es) 2010-09-07

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