PE20090803A1 - Compuestos triazolil aminopirimidin como inhibidores de plk1 - Google Patents
Compuestos triazolil aminopirimidin como inhibidores de plk1Info
- Publication number
- PE20090803A1 PE20090803A1 PE2008000797A PE2008000797A PE20090803A1 PE 20090803 A1 PE20090803 A1 PE 20090803A1 PE 2008000797 A PE2008000797 A PE 2008000797A PE 2008000797 A PE2008000797 A PE 2008000797A PE 20090803 A1 PE20090803 A1 PE 20090803A1
- Authority
- PE
- Peru
- Prior art keywords
- compounds
- triazolil
- methyl
- aminopyrimidin
- thiofen
- Prior art date
Links
- 108010056274 polo-like kinase 1 Proteins 0.000 title abstract 2
- LJXQPZWIHJMPQQ-UHFFFAOYSA-N pyrimidin-2-amine Chemical class NC1=NC=CC=N1 LJXQPZWIHJMPQQ-UHFFFAOYSA-N 0.000 title abstract 2
- 102100031463 Serine/threonine-protein kinase PLK1 Human genes 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical class C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 3
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 abstract 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 1
- XIPUIGPNIDKXJU-UHFFFAOYSA-N [CH]1CC1 Chemical class [CH]1CC1 XIPUIGPNIDKXJU-UHFFFAOYSA-N 0.000 abstract 1
- 150000005005 aminopyrimidines Chemical class 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93833307P | 2007-05-16 | 2007-05-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20090803A1 true PE20090803A1 (es) | 2009-07-11 |
Family
ID=39967594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008000797A PE20090803A1 (es) | 2007-05-16 | 2008-05-07 | Compuestos triazolil aminopirimidin como inhibidores de plk1 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8114872B2 (enExample) |
| EP (1) | EP2155735A2 (enExample) |
| JP (1) | JP5204838B2 (enExample) |
| KR (1) | KR101131254B1 (enExample) |
| CN (1) | CN101679396B (enExample) |
| AR (1) | AR066472A1 (enExample) |
| AU (1) | AU2008254318B2 (enExample) |
| BR (1) | BRPI0811611A2 (enExample) |
| CA (1) | CA2687474A1 (enExample) |
| CL (1) | CL2008001322A1 (enExample) |
| EA (1) | EA015574B1 (enExample) |
| MX (1) | MX2009012233A (enExample) |
| PE (1) | PE20090803A1 (enExample) |
| TW (1) | TW200902012A (enExample) |
| WO (1) | WO2008144222A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010513553A (ja) | 2006-12-21 | 2010-04-30 | イーライ リリー アンド カンパニー | 癌治療用イミダゾリジノニルアミノピリミジン化合物 |
| CN101563342B (zh) | 2006-12-21 | 2012-09-05 | 伊莱利利公司 | 用于治疗癌症的咪唑啉酮基氨基嘧啶化合物 |
| MX2009012228A (es) * | 2007-05-16 | 2009-12-01 | Lilly Co Eli | Compuesto de triazolil aminopirimidina. |
| EA015574B1 (ru) | 2007-05-16 | 2011-10-31 | Эли Лилли Энд Компани | Триазолиламинопиримидиновые соединения |
| MX374634B (es) | 2013-04-15 | 2025-03-06 | Fmc Corp Star | Amidas fungicidas. |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4929726A (en) | 1988-02-09 | 1990-05-29 | Georgia State University Foundation, Inc. | Novel diazines and their method of preparation |
| WO2004063192A1 (en) | 2003-01-10 | 2004-07-29 | Pharmacopeia Drug Discovery, Inc. | Imidazolyl pyrimidine derivatives useful as il-8 receptor modulators |
| GB0308466D0 (en) | 2003-04-11 | 2003-05-21 | Novartis Ag | Organic compounds |
| US7521457B2 (en) * | 2004-08-20 | 2009-04-21 | Boehringer Ingelheim International Gmbh | Pyrimidines as PLK inhibitors |
| JP2008510771A (ja) * | 2004-08-27 | 2008-04-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ジヒドロプテリジノン、その製造方法および医薬薬剤としてのその使用 |
| MX2007007032A (es) * | 2004-12-17 | 2007-07-04 | Amgen Inc | Compuestos de aminopirimidina y metodos de uso. |
| TW200800201A (en) | 2005-11-18 | 2008-01-01 | Lilly Co Eli | Pyrimidinyl benzothiophene compounds |
| US8008481B2 (en) | 2006-03-31 | 2011-08-30 | Ericsson Anna M | Indazole compounds |
| CN101563342B (zh) | 2006-12-21 | 2012-09-05 | 伊莱利利公司 | 用于治疗癌症的咪唑啉酮基氨基嘧啶化合物 |
| MX2009012228A (es) | 2007-05-16 | 2009-12-01 | Lilly Co Eli | Compuesto de triazolil aminopirimidina. |
| EA015574B1 (ru) | 2007-05-16 | 2011-10-31 | Эли Лилли Энд Компани | Триазолиламинопиримидиновые соединения |
-
2008
- 2008-05-07 EA EA200971067A patent/EA015574B1/ru not_active IP Right Cessation
- 2008-05-07 CL CL2008001322A patent/CL2008001322A1/es unknown
- 2008-05-07 AR ARP080101931A patent/AR066472A1/es unknown
- 2008-05-07 US US12/596,957 patent/US8114872B2/en not_active Expired - Fee Related
- 2008-05-07 CN CN2008800159078A patent/CN101679396B/zh not_active Expired - Fee Related
- 2008-05-07 TW TW097116887A patent/TW200902012A/zh unknown
- 2008-05-07 JP JP2010508499A patent/JP5204838B2/ja not_active Expired - Fee Related
- 2008-05-07 EP EP08755094A patent/EP2155735A2/en not_active Withdrawn
- 2008-05-07 MX MX2009012233A patent/MX2009012233A/es active IP Right Grant
- 2008-05-07 AU AU2008254318A patent/AU2008254318B2/en not_active Ceased
- 2008-05-07 BR BRPI0811611-3A2A patent/BRPI0811611A2/pt not_active IP Right Cessation
- 2008-05-07 PE PE2008000797A patent/PE20090803A1/es not_active Application Discontinuation
- 2008-05-07 WO PCT/US2008/062799 patent/WO2008144222A2/en not_active Ceased
- 2008-05-07 KR KR1020097023738A patent/KR101131254B1/ko not_active Expired - Fee Related
- 2008-05-07 CA CA2687474A patent/CA2687474A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008144222A3 (en) | 2009-01-15 |
| US20100130466A1 (en) | 2010-05-27 |
| MX2009012233A (es) | 2009-12-01 |
| EA200971067A1 (ru) | 2010-04-30 |
| CN101679396B (zh) | 2012-06-06 |
| AU2008254318B2 (en) | 2012-04-05 |
| AU2008254318A1 (en) | 2008-11-27 |
| JP2010527364A (ja) | 2010-08-12 |
| JP5204838B2 (ja) | 2013-06-05 |
| CA2687474A1 (en) | 2008-11-27 |
| US8114872B2 (en) | 2012-02-14 |
| CN101679396A (zh) | 2010-03-24 |
| EA015574B1 (ru) | 2011-10-31 |
| TW200902012A (en) | 2009-01-16 |
| CL2008001322A1 (es) | 2009-05-22 |
| AR066472A1 (es) | 2009-08-19 |
| BRPI0811611A2 (pt) | 2014-11-04 |
| WO2008144222A2 (en) | 2008-11-27 |
| KR101131254B1 (ko) | 2012-04-24 |
| EP2155735A2 (en) | 2010-02-24 |
| KR20090130246A (ko) | 2009-12-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |