KR101131254B1 - 트리아졸릴 아미노피리미딘 화합물 - Google Patents

트리아졸릴 아미노피리미딘 화합물 Download PDF

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Publication number
KR101131254B1
KR101131254B1 KR1020097023738A KR20097023738A KR101131254B1 KR 101131254 B1 KR101131254 B1 KR 101131254B1 KR 1020097023738 A KR1020097023738 A KR 1020097023738A KR 20097023738 A KR20097023738 A KR 20097023738A KR 101131254 B1 KR101131254 B1 KR 101131254B1
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KR
South Korea
Prior art keywords
methyl
fluoro
mmol
ethyl
alkyl
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Expired - Fee Related
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KR1020097023738A
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English (en)
Korean (ko)
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KR20090130246A (ko
Inventor
해롤드 번즈 브룩스
조이스 지. 크리치
제임스 로버트 헨리
홍 후
델루 지앙
홍-유 리
사친 고빈들랄 마니아르
윌리엄 토마스 맥밀렌
제이슨 스캇 소이어
멜리사 케이트 슬레이터
얀 왕
Original Assignee
일라이 릴리 앤드 캄파니
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Application filed by 일라이 릴리 앤드 캄파니 filed Critical 일라이 릴리 앤드 캄파니
Publication of KR20090130246A publication Critical patent/KR20090130246A/ko
Application granted granted Critical
Publication of KR101131254B1 publication Critical patent/KR101131254B1/ko
Expired - Fee Related legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020097023738A 2007-05-16 2008-05-07 트리아졸릴 아미노피리미딘 화합물 Expired - Fee Related KR101131254B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93833307P 2007-05-16 2007-05-16
US60/938,333 2007-05-16
PCT/US2008/062799 WO2008144222A2 (en) 2007-05-16 2008-05-07 Triazolyl aminopyrimidine compounds

Publications (2)

Publication Number Publication Date
KR20090130246A KR20090130246A (ko) 2009-12-21
KR101131254B1 true KR101131254B1 (ko) 2012-04-24

Family

ID=39967594

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020097023738A Expired - Fee Related KR101131254B1 (ko) 2007-05-16 2008-05-07 트리아졸릴 아미노피리미딘 화합물

Country Status (15)

Country Link
US (1) US8114872B2 (enExample)
EP (1) EP2155735A2 (enExample)
JP (1) JP5204838B2 (enExample)
KR (1) KR101131254B1 (enExample)
CN (1) CN101679396B (enExample)
AR (1) AR066472A1 (enExample)
AU (1) AU2008254318B2 (enExample)
BR (1) BRPI0811611A2 (enExample)
CA (1) CA2687474A1 (enExample)
CL (1) CL2008001322A1 (enExample)
EA (1) EA015574B1 (enExample)
MX (1) MX2009012233A (enExample)
PE (1) PE20090803A1 (enExample)
TW (1) TW200902012A (enExample)
WO (1) WO2008144222A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101563342B (zh) 2006-12-21 2012-09-05 伊莱利利公司 用于治疗癌症的咪唑啉酮基氨基嘧啶化合物
US8063212B2 (en) 2006-12-21 2011-11-22 Eli Lilly And Company Imidazolidinonyl aminopyrimidine compounds for the treatment of cancer
PE20090803A1 (es) 2007-05-16 2009-07-11 Lilly Co Eli Compuestos triazolil aminopirimidin como inhibidores de plk1
MX2009012228A (es) * 2007-05-16 2009-12-01 Lilly Co Eli Compuesto de triazolil aminopirimidina.
CN105121411B (zh) 2013-04-15 2017-10-10 杜邦公司 杀真菌酰胺

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006066172A1 (en) 2004-12-17 2006-06-22 Amgen, Inc. Aminopyrimidine compounds and methods of use

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4929726A (en) * 1988-02-09 1990-05-29 Georgia State University Foundation, Inc. Novel diazines and their method of preparation
WO2004063192A1 (en) 2003-01-10 2004-07-29 Pharmacopeia Drug Discovery, Inc. Imidazolyl pyrimidine derivatives useful as il-8 receptor modulators
GB0308466D0 (en) 2003-04-11 2003-05-21 Novartis Ag Organic compounds
US7521457B2 (en) * 2004-08-20 2009-04-21 Boehringer Ingelheim International Gmbh Pyrimidines as PLK inhibitors
WO2006021548A1 (de) * 2004-08-27 2006-03-02 Boehringer Ingelheim International Gmbh Dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel
TW200800201A (en) 2005-11-18 2008-01-01 Lilly Co Eli Pyrimidinyl benzothiophene compounds
MX2008012482A (es) 2006-03-31 2008-10-10 Abbott Lab Compuestos de indazol.
CN101563342B (zh) 2006-12-21 2012-09-05 伊莱利利公司 用于治疗癌症的咪唑啉酮基氨基嘧啶化合物
PE20090803A1 (es) 2007-05-16 2009-07-11 Lilly Co Eli Compuestos triazolil aminopirimidin como inhibidores de plk1
MX2009012228A (es) 2007-05-16 2009-12-01 Lilly Co Eli Compuesto de triazolil aminopirimidina.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006066172A1 (en) 2004-12-17 2006-06-22 Amgen, Inc. Aminopyrimidine compounds and methods of use

Also Published As

Publication number Publication date
KR20090130246A (ko) 2009-12-21
US20100130466A1 (en) 2010-05-27
EP2155735A2 (en) 2010-02-24
BRPI0811611A2 (pt) 2014-11-04
PE20090803A1 (es) 2009-07-11
JP5204838B2 (ja) 2013-06-05
TW200902012A (en) 2009-01-16
CN101679396B (zh) 2012-06-06
US8114872B2 (en) 2012-02-14
AR066472A1 (es) 2009-08-19
WO2008144222A2 (en) 2008-11-27
CA2687474A1 (en) 2008-11-27
AU2008254318B2 (en) 2012-04-05
EA015574B1 (ru) 2011-10-31
AU2008254318A1 (en) 2008-11-27
EA200971067A1 (ru) 2010-04-30
JP2010527364A (ja) 2010-08-12
CL2008001322A1 (es) 2009-05-22
WO2008144222A3 (en) 2009-01-15
MX2009012233A (es) 2009-12-01
CN101679396A (zh) 2010-03-24

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