PE20081490A1 - N-(4-(2-amino-3-cloropiridin-4-iloxi)-3-fluorofenil)-4-etoxi-1-(4-fluorofenil)-2-oxo-1,2-dihidropiridina-3-carboxamida y una composicion farmaceutica - Google Patents

N-(4-(2-amino-3-cloropiridin-4-iloxi)-3-fluorofenil)-4-etoxi-1-(4-fluorofenil)-2-oxo-1,2-dihidropiridina-3-carboxamida y una composicion farmaceutica

Info

Publication number
PE20081490A1
PE20081490A1 PE2007001538A PE2007001538A PE20081490A1 PE 20081490 A1 PE20081490 A1 PE 20081490A1 PE 2007001538 A PE2007001538 A PE 2007001538A PE 2007001538 A PE2007001538 A PE 2007001538A PE 20081490 A1 PE20081490 A1 PE 20081490A1
Authority
PE
Peru
Prior art keywords
fluorophenyl
iloxi
etoxy
chloropyridin
dihydropyridine
Prior art date
Application number
PE2007001538A
Other languages
English (en)
Inventor
Robert M Borzilleri
Gretchen M Schroeder
Zhen-Wei Cai
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20081490A1 publication Critical patent/PE20081490A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE UNA CANTIDAD EFECTIVA DEL COMPUESTO N-(4-(2-AMINO-3-CLOROPIRIDIN-4-ILOXI)-3-FLUOROFENIL)-4-ETOXI-1-(4-FLUOROFENIL)-2-OXO-1,2-DIHIDROPIRIDINA-3-CARBOXAMIDA, EN UN PORTADOR QUE COMPRENDE CELULOSA MICROCRISTALINA Y MANITOL O LACTOSA Y ADEMAS COMPRENDE UN AGENTE LUBRICANTE Y DESINTEGRANTE, SIENDO UTIL EN EL TRATAMIENTO DEL CANCER DEPENDIENTE DE LA ACTIVACION DE Met REGULADA POR LA AMPLIFICACION DEL GEN, UNA MUTACION Met ACTIVADA Y/O ESTIMULACION HGF
PE2007001538A 2006-11-08 2007-11-08 N-(4-(2-amino-3-cloropiridin-4-iloxi)-3-fluorofenil)-4-etoxi-1-(4-fluorofenil)-2-oxo-1,2-dihidropiridina-3-carboxamida y una composicion farmaceutica PE20081490A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85754006P 2006-11-08 2006-11-08

Publications (1)

Publication Number Publication Date
PE20081490A1 true PE20081490A1 (es) 2008-10-30

Family

ID=39048786

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001538A PE20081490A1 (es) 2006-11-08 2007-11-08 N-(4-(2-amino-3-cloropiridin-4-iloxi)-3-fluorofenil)-4-etoxi-1-(4-fluorofenil)-2-oxo-1,2-dihidropiridina-3-carboxamida y una composicion farmaceutica

Country Status (21)

Country Link
US (2) US7851489B2 (es)
EP (1) EP2089364B1 (es)
JP (1) JP5276005B2 (es)
KR (1) KR101390076B1 (es)
CN (1) CN101535264B (es)
AR (1) AR063628A1 (es)
AU (1) AU2007317296B2 (es)
CA (1) CA2669266C (es)
CL (1) CL2007003226A1 (es)
DK (1) DK2089364T3 (es)
ES (1) ES2424851T3 (es)
HK (1) HK1131608A1 (es)
HR (1) HRP20130626T1 (es)
MX (1) MX2009004699A (es)
NO (1) NO342395B1 (es)
PE (1) PE20081490A1 (es)
PL (1) PL2089364T3 (es)
PT (1) PT2089364E (es)
SI (1) SI2089364T1 (es)
TW (1) TWI409259B (es)
WO (1) WO2008058229A1 (es)

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Also Published As

Publication number Publication date
CL2007003226A1 (es) 2008-02-08
CA2669266C (en) 2014-04-29
TWI409259B (zh) 2013-09-21
EP2089364A1 (en) 2009-08-19
ES2424851T3 (es) 2013-10-09
HK1131608A1 (en) 2010-01-29
CA2669266A1 (en) 2008-05-15
TW200829564A (en) 2008-07-16
KR101390076B1 (ko) 2014-04-29
AU2007317296A1 (en) 2008-05-15
AR063628A1 (es) 2009-02-04
WO2008058229A1 (en) 2008-05-15
MX2009004699A (es) 2009-05-15
CN101535264B (zh) 2012-11-28
AU2007317296B2 (en) 2012-07-05
CN101535264A (zh) 2009-09-16
DK2089364T3 (da) 2013-09-02
US8536200B2 (en) 2013-09-17
PL2089364T3 (pl) 2013-11-29
NO342395B1 (no) 2018-05-14
JP5276005B2 (ja) 2013-08-28
EP2089364B1 (en) 2013-06-12
US20110052583A1 (en) 2011-03-03
KR20090096423A (ko) 2009-09-10
JP2010509362A (ja) 2010-03-25
PT2089364E (pt) 2013-08-26
NO20091605L (no) 2009-05-27
US20080114033A1 (en) 2008-05-15
HRP20130626T1 (en) 2013-08-31
US7851489B2 (en) 2010-12-14
SI2089364T1 (sl) 2013-10-30

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