PE20081381A1 - Adsorbente de fosfato basado en hierro iii - Google Patents

Adsorbente de fosfato basado en hierro iii

Info

Publication number
PE20081381A1
PE20081381A1 PE2007001773A PE2007001773A PE20081381A1 PE 20081381 A1 PE20081381 A1 PE 20081381A1 PE 2007001773 A PE2007001773 A PE 2007001773A PE 2007001773 A PE2007001773 A PE 2007001773A PE 20081381 A1 PE20081381 A1 PE 20081381A1
Authority
PE
Peru
Prior art keywords
phosphate
polynuclear
iii
iron
refers
Prior art date
Application number
PE2007001773A
Other languages
English (en)
Inventor
Michael Ambuhl
Christa Hartmann
Daniel Kaufmann
Ulrich Meier
Nabila Sekkat
Corine Gessier-Vial
Ernst Kusters
Andreas Meyer
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38983614&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20081381(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP06126122A external-priority patent/EP1932807A1/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20081381A1 publication Critical patent/PE20081381A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/26Iron; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/06Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group B01J20/04
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/223Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material containing metals, e.g. organo-metallic compounds, coordination complexes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/2803Sorbents comprising a binder, e.g. for forming aggregated, agglomerated or granulated products
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01GCOMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G49/00Compounds of iron
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01GCOMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G49/00Compounds of iron
    • C01G49/0018Mixed oxides or hydroxides
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01GCOMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G49/00Compounds of iron
    • C01G49/02Oxides; Hydroxides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02Iron compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • External Artificial Organs (AREA)

Abstract

SE REFIERE A UNA COMPOSICION ADSORBENTE DE FOSFATO BASADO EN HIERRO III POLINUCLEAR QUE TIENE UNA CAPACIDAD DE ENLACE DE FOSFATO DE 120MG A 140MG DE FOSFATO ADSORBIDO POR 1G DE ADSORBENTE DE FOSFATO Y COMPRENDE: A) UN MATERIAL BASE DE ADSORBENTE TAL COMO ALMIDON; B) HIDROXIDO DE OXIDO DE HIERRO-GAMMA POLINUCLEAR; C) UN CARBOHIDRATO SOLUBLE TAL COMO UN DERIVADO DE GLUCOSA QUE SE INCORPORA PARCIALMENTE EN LOS HIDROXIDOS DE OXIDO DE HIERRO III POLINUCLEARES; D) UN CONSERVADOR TAL COMO ETANOL. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y FORMAS FARMACEUTICAS. DICHA COMPOSICION REMUEVE O CONTROLA EL FOSFATO INORGANICO TAL COMO FOSFATO DE CALCIO DE FLUIDOS DE DIALISIS, SANGRE O PLASMA SIENDO UTIL EN EL TRATAMIENTO O PREVENCION DE HIPERFOSFATEMIA, HIPERCALCEMIA, CALCIFILAXIS
PE2007001773A 2006-12-14 2007-12-12 Adsorbente de fosfato basado en hierro iii PE20081381A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06126122A EP1932807A1 (en) 2006-12-14 2006-12-14 Inorganic compounds
EP06126101 2006-12-14

Publications (1)

Publication Number Publication Date
PE20081381A1 true PE20081381A1 (es) 2008-11-12

Family

ID=38983614

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001773A PE20081381A1 (es) 2006-12-14 2007-12-12 Adsorbente de fosfato basado en hierro iii

Country Status (24)

Country Link
US (2) US8252310B2 (es)
JP (1) JP5456969B2 (es)
KR (1) KR20090094820A (es)
AR (1) AR064301A1 (es)
AU (1) AU2007331482B2 (es)
BR (1) BRPI0720272A2 (es)
CA (1) CA2671828C (es)
CL (1) CL2007003606A1 (es)
EC (1) ECSP099410A (es)
ES (1) ES2526171T3 (es)
HK (1) HK1133248A1 (es)
IL (1) IL198548A0 (es)
MA (1) MA30993B1 (es)
MX (1) MX2009006307A (es)
MY (1) MY151047A (es)
NO (1) NO342285B1 (es)
NZ (1) NZ576672A (es)
PE (1) PE20081381A1 (es)
PT (1) PT2319804E (es)
RU (1) RU2447933C2 (es)
SI (1) SI2319804T1 (es)
TN (1) TN2009000214A1 (es)
TW (1) TWI465239B (es)
WO (1) WO2008071747A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9720061D0 (en) 1997-09-19 1997-11-19 Crosfield Joseph & Sons Metal compounds as phosphate binders
MY157620A (en) 2006-01-31 2016-06-30 Cytochroma Dev Inc A granular material of a solid water-soluble mixed metal compound capable of binding phosphate
GB0714670D0 (en) 2007-07-27 2007-09-05 Ineos Healthcare Ltd Use
GB0720220D0 (en) 2007-10-16 2007-11-28 Ineos Healthcare Ltd Compound
TWI468167B (zh) 2007-11-16 2015-01-11 威佛(國際)股份有限公司 藥學組成物
JP2009292119A (ja) 2008-06-09 2009-12-17 Alps Electric Co Ltd サーマルヘッド
US20110086097A1 (en) * 2008-06-13 2011-04-14 Daniel Kaufmann Manufacture process for the preparation of an iron containing phosphate adsorbent
GB0814326D0 (en) * 2008-08-05 2008-09-10 Medical Res Council Phosphate binding materials and their uses
AU2010276242B2 (en) 2009-07-21 2014-05-29 Keryx Biopharmaceuticals, Inc. Ferric citrate dosage forms
GB0913525D0 (en) 2009-08-03 2009-09-16 Ineos Healthcare Ltd Method
GB201001779D0 (en) 2010-02-04 2010-03-24 Ineos Healthcare Ltd Composition
DE102011112898A1 (de) 2011-09-08 2013-03-14 Charité - Universitätsmedizin Berlin Nanopartikuläres Phosphatadsorbens basierend auf Maghämit oder Maghämit/Magnetit, dessen Herstellung und Verwendungen
US9566303B2 (en) * 2011-10-13 2017-02-14 Vidasym, Inc. Iron-fiber composition, preparation and uses thereof
RU2496722C1 (ru) * 2012-04-10 2013-10-27 Леонид Асхатович Мазитов Способ очистки сточной воды от фосфатов
WO2014138016A1 (en) 2013-03-08 2014-09-12 Vidasym, Inc. Metal ion-functional fiber component complex compositions, preparation and uses thereof
US9339489B2 (en) * 2013-03-15 2016-05-17 Aprecia Pharmaceuticals Company Rapid disperse dosage form containing levetiracetam
CA2906029C (en) * 2013-03-15 2017-09-05 Aprecia Pharmaceuticals Company Rapid disperse dosage form containing levetiracetam
ES2820737T3 (es) 2013-11-27 2021-04-22 Vifor Fresenius Medical Care Renal Pharma Ltd Composición farmacéutica que comprende partículas de quelante de fosfato
EP3157516A4 (en) 2014-06-22 2017-12-13 Dexcel Pharma Technologies Ltd. Pharmaceutical compositions comprising ferric citrate and methods for the production thereof
US9901918B2 (en) 2015-03-04 2018-02-27 Graver Technologies Llc Hybrid ion exchange material and method for making the same
CN105193844A (zh) * 2015-05-27 2015-12-30 合肥川迪医药技术有限公司 用于制备含δ-羟基氧化铁(多核)及其药物组合物的方法及在高磷血症领域中的应用
WO2017172633A1 (en) * 2016-03-28 2017-10-05 New Sky Energy Intellectual Property Holding Company, Llc Methods of producing ferrihydrite nanoparticle slurries, and systems and products employing the same
EP3829761A1 (en) 2018-07-30 2021-06-09 Interquim S.A. Process for preparing an adsorbent for phosphate in aqueous medium
KR20220154086A (ko) * 2020-01-16 2022-11-21 비포 프레제니우스 메디컬 케어 레날 파마 리미티드 (비포 프레제니우스 메디컬 케어 레날 파마 아게) 철(iii)-옥시하이드록사이드, 수크로스 및 하나 이상의 전분의 혼합물, 바람직하게는 수크로페릭 옥시하이드록사이드의 혼합물의 입자
CN115317494B (zh) * 2022-07-22 2024-02-13 康瑞鑫(天津)药物研究院有限公司 高磷酸盐结合力的蔗糖氢氧化氧铁及其制备方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2885393A (en) 1956-02-24 1959-05-05 R K Laros Company Dextran-iron complex and process for making same
US3697502A (en) 1969-11-03 1972-10-10 Christensen Henry M Method of making iron dextran-preparations
US3951821A (en) * 1972-07-14 1976-04-20 The Dow Chemical Company Disintegrating agent for tablets
US4180567A (en) 1977-09-02 1979-12-25 Pharmachem Corporation Iron preparations and methods of making and administering the same
DE3026868C2 (de) 1980-07-16 1986-03-13 Laboratorien Hausmann AG, St. Gallen Verfahren zur Herstellung von Eisen(III)hydroxid-Dextran-Komplexen und sie enthaltende pharmazeutische sterile wäßrige Lösung
US4569836A (en) 1981-08-27 1986-02-11 Gordon Robert T Cancer treatment by intracellular hyperthermia
EP0330801A1 (en) 1983-02-08 1989-09-06 Schering Aktiengesellschaft Ferromagnetic, diamagnetic or paramagnetic particles useful in the diagnosis and treatment of disease
DE3422249A1 (de) 1984-06-15 1985-12-19 Pfeifer & Langen, 5000 Köln Wasserloesliches eisendextran und verfahren zu seiner herstellung
EP0166315B1 (de) 1984-06-19 1989-08-23 BASF Aktiengesellschaft Magensaftresistent überzogene zylindrische Pankreatin-Mikrotabletten
US5055288A (en) 1987-06-26 1991-10-08 Advanced Magnetics, Inc. Vascular magnetic imaging method and agent comprising biodegradeable superparamagnetic metal oxides
US4827945A (en) 1986-07-03 1989-05-09 Advanced Magnetics, Incorporated Biologically degradable superparamagnetic materials for use in clinical applications
US4970079A (en) 1989-06-05 1990-11-13 Purdue Research Foundation Method and composition of oxy-iron compounds for treatment of hyperphosphatemia
IL98744A0 (en) 1990-07-06 1992-07-15 Gen Hospital Corp Method of studying biological tissue using monocrystalline particles
SU1807606A1 (ru) * 1991-03-29 1995-08-09 Пермский политехнический институт Способ получения анионообменника на основе гидроксида титана
US5234697A (en) 1992-06-22 1993-08-10 Digestive Care Inc. Compositions of gastric acid-resistant microspheres containing salts of bile acids
EP0585898B1 (en) 1992-09-04 1998-08-05 Mitsubishi Chemical Corporation Process for the production and use of an anion exchange resin
DE4239442C2 (de) 1992-11-24 2001-09-13 Sebo Gmbh Verwendung eines mit polynuklearen Metalloxidhydroxiden modifizierten Adsorptionsmaterials zur selektiven Elimination von anorganischem Phosphat aus proteinhaltigen Flüssigkeiten
DE19547356A1 (de) 1995-12-19 1997-06-26 Vifor Int Ag Adsorbens für Phosphat aus wäßrigem Medium, dessen Herstellung und Verwendung
US5906978A (en) * 1996-08-14 1999-05-25 Hemocleanse, Inc. Method for iron delivery to a patient by transfer from dialysate
GB9720061D0 (en) 1997-09-19 1997-11-19 Crosfield Joseph & Sons Metal compounds as phosphate binders
DE10128511A1 (de) 2001-06-13 2002-12-19 Sebo Gmbh Verwendung eines Phosphatadsorbers gegen Gefäßerkrankungen
JPWO2003053565A1 (ja) 2001-12-21 2005-04-28 室町ケミカル株式会社 リン酸の吸着剤
DE102004031181A1 (de) 2004-06-28 2006-01-19 Vifor (International) Ag Phosphatadsorbens

Also Published As

Publication number Publication date
CA2671828A1 (en) 2008-06-19
AU2007331482A1 (en) 2008-06-19
HK1133248A1 (en) 2010-03-19
SI2319804T1 (sl) 2015-01-30
RU2447933C2 (ru) 2012-04-20
BRPI0720272A2 (pt) 2014-01-28
NO342285B1 (no) 2018-04-30
MY151047A (en) 2014-03-31
MA30993B1 (fr) 2009-12-01
US20120126440A1 (en) 2012-05-24
TW200831115A (en) 2008-08-01
JP2008150375A (ja) 2008-07-03
RU2009126614A (ru) 2011-01-20
AR064301A1 (es) 2009-03-25
MX2009006307A (es) 2009-06-23
PT2319804E (pt) 2014-11-24
US20080145410A1 (en) 2008-06-19
CL2007003606A1 (es) 2008-07-18
US8252310B2 (en) 2012-08-28
WO2008071747A1 (en) 2008-06-19
IL198548A0 (en) 2010-02-17
ECSP099410A (es) 2009-07-31
NO20092632L (no) 2009-07-14
AU2007331482B2 (en) 2011-04-21
CA2671828C (en) 2012-06-19
TWI465239B (zh) 2014-12-21
JP5456969B2 (ja) 2014-04-02
ES2526171T3 (es) 2015-01-07
TN2009000214A1 (en) 2010-10-18
KR20090094820A (ko) 2009-09-08
NZ576672A (en) 2012-02-24

Similar Documents

Publication Publication Date Title
PE20081381A1 (es) Adsorbente de fosfato basado en hierro iii
UA100497C2 (ru) Комбинированное лечение сахарного диабета
CL2009001065A1 (es) Compuestos derivados de 4-pirimidinil-1,3-tiazol (o 1,3-oxazol) sulfonamidas sustituidas, inhibidores de quinasas raf; composicion farmaceutica; procedimiento de preparacion; y uso para tratar un neoplasma susceptible, seleccionado de adenocarcinoma de barret, carcinomas del tracto biliar y cancer de seno, entre otros.
BR112012016797A2 (pt) intensificador dinâmico de baixo utilizando compressor com equalizador incorporado
WO2008070593A3 (en) Variant target binding agents and uses thereof
EA201300242A1 (ru) Фармацевтические композиции, содержащие замещенные ациланилиды
MX2009007254A (es) Composiciones de tableta en tableta.
UY29086A1 (es) Nuevas composiciones farmacéuticas para el tratamiento de trastornos hiperproliferativos.
EA200970067A1 (ru) Агонисты ep2
UY30364A1 (es) Arilimidazolonas y ariltriazolonas sustituidas asi como su uso
EP1983002A3 (en) Tyrosine phosphorylation sites and antibodies specific for them
WO2008075192A3 (en) Targeting and therapeutic compounds and gas-filled microvesicles comprising said com ounds
UY31765A (es) Dihidropirazolonas sustituidas y su uso
CL2007002890A1 (es) Compuestos derivados de 2-piridincarboxamida, activador de glucosinasa; composicion farmaceutica; y uso del compuesto para el tratamiento de diabetes o la obesidad.
WO2009101205A3 (en) Immunogenic control of tumours and tumour cells
MY157334A (en) Sigma ligands for the prevention pr treatment of pain induced by chemotheraphy
CL2009000757A1 (es) Compuestos derivados de 6,8,2´-tris-(isobut-2-en-1-il)-diosmetina; procedimientos para su elaboracion; composicion farmaceutica que los comprende; y su uso en el tratamiento de enfermedades venosas cronicas, sindrome post-trombotico, complicaciones vasculares ligadas a la diabetes, entre otras.
CL2008003546A1 (es) Compuestos derivados de piridina; procedimiento de preparacion; composicion farmaceutica de dichos compuestos; y uso en el tratamiento y/o profilaxis de la diabetes mellitus tipo i y/o tipo ii.
CR11126A (es) Inhibicion de metastasis de tumor por anticuerpos anti neuropilina 2
WO2009108932A3 (en) Selectin ligands useful in the diagnosis and treatment of cancer
CR9300A (es) Uso de compuestos de hierro (iii)
EA200900261A1 (ru) Применение эсцина
GT200600106A (es) Agentes endoparasiticidas
EP1975184A3 (en) Serine or threonine phosphorylation sites
EP2084178A4 (en) CONJUGATES OF CYTOTOXIC COMPOUNDS WITH PEPTIDES

Legal Events

Date Code Title Description
FC Refusal