PE20080427A1 - Agentes antivirales - Google Patents

Agentes antivirales

Info

Publication number
PE20080427A1
PE20080427A1 PE2007000902A PE2007000902A PE20080427A1 PE 20080427 A1 PE20080427 A1 PE 20080427A1 PE 2007000902 A PE2007000902 A PE 2007000902A PE 2007000902 A PE2007000902 A PE 2007000902A PE 20080427 A1 PE20080427 A1 PE 20080427A1
Authority
PE
Peru
Prior art keywords
carboxi
quinolin
pyrrol
thiazol
dimethyl
Prior art date
Application number
PE2007000902A
Other languages
English (en)
Inventor
Franz Ulrich Schmitz
Christopher Don Roberts
Ronald Conrad Griffith
Janos Botyanszki
Son Mihn Pham
Original Assignee
Genelabs Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genelabs Tech Inc filed Critical Genelabs Tech Inc
Publication of PE20080427A1 publication Critical patent/PE20080427A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE Y ES ARILO, HETEROARILO, HETEROARILO SUSTITUIDO, ENTRE OTROS; HET ES ARILENO DE 6 MIEMBROS, UN HETEROARILENO DE 6 MIEMBROS QUE CONTIENE 1, 2 o 3 HETEROATOMOS SELECCIONADOS ENTRE N, O, S Y UN ANILLO BICICLICO DE FORMULAS II, III, ENTRE OTROS; W1, W4 Y W5 SON CADA UNO N, CH; W3 ES N, CH, UNA UNION CON LA SALVEDAD DE QUE NO MAS QUE UN NITROGENO EN EL ANILLO BICICLICO SE OXIDA OPCIONALMENTE PARA FORMAR N-OXIDO; LA LINEA PUNTEADA ES UN ENLACE DOBLE O SIMPLE; UNO DE D o E C-Ra, Y EL OTRO DE D o E ES S; Ra Y R SON CADA UNO H, ALQUILO, ALQUILO SUSTITUIDO; Q ES CICLOALQUILO SUSTITUIDO O NO, CICLOALQUENILO, HETEROCICLO, ENTRE OTROS; Z ES CARBOXI, CARBOXI ESTER, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: ACIDO 6-CICLOPENTIL-5-[2-(2,4-DIMETIL-TIAZOL-5-IL)-QUINOLIN-6-IL]-4-(2-MORFOLIN-4-IL-2-OXO-ETIL)-4H-TIENO[3,2-b]PIRROL-2-CARBOXILICO; ACIDO {6-CICLOHEXIL-5-[2-(2,4-DIMETIL-TIAZOL-5-IL)-QUINOLIN-6-IL]-2-METANSULFONILAMINOCARBONIL-TIENO[3,2-b]PIRROL-4-IL}-ACETICO; ENTRE OTROS. DICHO COMPUESTO ES UTIL EN EL TRATAMIENTO DE HEPATITIS C MEDIADA POR EL VIRUS FLAVIVIRIDAE
PE2007000902A 2006-07-14 2007-07-13 Agentes antivirales PE20080427A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83104006P 2006-07-14 2006-07-14

Publications (1)

Publication Number Publication Date
PE20080427A1 true PE20080427A1 (es) 2008-06-11

Family

ID=38742551

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000902A PE20080427A1 (es) 2006-07-14 2007-07-13 Agentes antivirales

Country Status (13)

Country Link
EP (1) EP2044083A1 (es)
JP (1) JP2009543807A (es)
KR (1) KR20090033881A (es)
CN (1) CN101490058A (es)
AR (1) AR062258A1 (es)
AU (1) AU2007272441A1 (es)
BR (1) BRPI0714346A2 (es)
CA (1) CA2657651A1 (es)
MX (1) MX2009000513A (es)
PE (1) PE20080427A1 (es)
RU (1) RU2009105196A (es)
TW (1) TW200813070A (es)
WO (2) WO2008008907A2 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070049593A1 (en) 2004-02-24 2007-03-01 Japan Tobacco Inc. Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor
US7659263B2 (en) 2004-11-12 2010-02-09 Japan Tobacco Inc. Thienopyrrole compound and use thereof as HCV polymerase inhibitor
ATE548044T1 (de) 2007-05-04 2012-03-15 Vertex Pharma Kombinationstherapie zur behandlung von hiv- infektionen
MX2012006877A (es) 2009-12-18 2012-08-31 Idenix Pharmaceuticals Inc Inhibidores de virus de hepatitis c de arileno o heteroarileno 5, 5 - fusionado.
WO2012087833A1 (en) * 2010-12-22 2012-06-28 Abbott Laboratories Hepatitis c inhibitors and uses thereof
US20120252721A1 (en) * 2011-03-31 2012-10-04 Idenix Pharmaceuticals, Inc. Methods for treating drug-resistant hepatitis c virus infection with a 5,5-fused arylene or heteroarylene hepatitis c virus inhibitor
FR3008975A1 (fr) * 2013-07-23 2015-01-30 Servier Lab Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
RU2546006C1 (ru) 2014-03-07 2015-04-10 Римма Ильинична Ашкинази Противовирусное средство
WO2016118043A1 (ru) 2015-01-20 2016-07-28 Виктор Вениаминович ТЕЦ Гемостатическое средство
US10167293B2 (en) * 2016-05-26 2019-01-01 Bayer Pharma Aktiengesellschaft [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanones
US11285170B2 (en) 2017-05-24 2022-03-29 Viktor Veniaminovich Tets Fractionated antimicrobial compositions and use thereof
MX2023012110A (es) * 2021-04-16 2023-10-24 Gilead Sciences Inc Compuestos de tienopirrol.
CN117957234A (zh) 2021-09-10 2024-04-30 吉利德科学公司 噻吩并吡咯化合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1401825E (pt) * 2001-06-11 2009-10-23 Virochem Pharma Inc Compostos e métodos para o tratamento ou para a prevenção de infecções com flavivírus
RU2375350C2 (ru) * 2003-06-04 2009-12-10 Смитклайн Бичам Корпорейшн Азотсодержащие производные гетероарила

Also Published As

Publication number Publication date
AU2007272441A1 (en) 2008-01-17
BRPI0714346A2 (pt) 2013-03-19
WO2008008912A1 (en) 2008-01-17
EP2044083A1 (en) 2009-04-08
WO2008008907A2 (en) 2008-01-17
WO2008008907A3 (en) 2008-03-20
AU2007272441A2 (en) 2009-03-19
CA2657651A1 (en) 2008-01-17
RU2009105196A (ru) 2010-08-27
AR062258A1 (es) 2008-10-29
MX2009000513A (es) 2009-03-09
TW200813070A (en) 2008-03-16
KR20090033881A (ko) 2009-04-06
CN101490058A (zh) 2009-07-22
JP2009543807A (ja) 2009-12-10

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