PE20070852A1 - Compuestos derivados de hidantoina como inhibidores de la enzima de conversion del factor alfa de necrosis tumoral (tace) - Google Patents

Compuestos derivados de hidantoina como inhibidores de la enzima de conversion del factor alfa de necrosis tumoral (tace)

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Publication number
PE20070852A1
PE20070852A1 PE2007000035A PE2007000035A PE20070852A1 PE 20070852 A1 PE20070852 A1 PE 20070852A1 PE 2007000035 A PE2007000035 A PE 2007000035A PE 2007000035 A PE2007000035 A PE 2007000035A PE 20070852 A1 PE20070852 A1 PE 20070852A1
Authority
PE
Peru
Prior art keywords
enzyme
tace
hydantoin
inhibitors
tumor necrosis
Prior art date
Application number
PE2007000035A
Other languages
English (en)
Inventor
Brian J Lavey
Joseph A Kozlowski
Guowei Zhou
Ling Tong
Michael K C Wong
Bandarpalle Shankar
Neng-Yang Shih
M Arshad Siddiqui
Kristin E Rosner
Chaoyang Dai
Janeta Papovici-Muller
Vinay M Girijavallabhan
Dansu Li
Razia K Rizvi
Lei Chen
De-Yi Yang
Robert Feltz
Seong-Heon Kim
Vincent S Madison
Zhuyan Guo
Aneta M Micula
Peter Orth
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20070852A1 publication Critical patent/PE20070852A1/es

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    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE HIDANTOINA DE FORMULA (a), (b), (c), ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE METALOPROTEINASAS DE MATRIZ (MMPs), METALOPROTEASAS DESINTEGRINA (ADAMs) Y LA ENZIMA DE CONVERSION DEL FACTOR ALFA DE NECROSIS TUMORAL (TACE) EVITANDO LA LIBERACION DEL FACTOR ALFA DE NECROSIS TUMORAL SIENDO UTILES EN EL TRATAMIENTO DE ARTRITIS REUMATOIDEA, ESCLEROSIS MULTIPLE, PSORIASIS, ENFERMEDAD DE CROHN, LUPUS ERITEMATOSO SISTEMICO, ASMA
PE2007000035A 2006-01-17 2007-01-15 Compuestos derivados de hidantoina como inhibidores de la enzima de conversion del factor alfa de necrosis tumoral (tace) PE20070852A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/333,663 US7504424B2 (en) 2004-07-16 2006-01-17 Compounds for the treatment of inflammatory disorders

Publications (1)

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PE20070852A1 true PE20070852A1 (es) 2007-09-24

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PE2007000035A PE20070852A1 (es) 2006-01-17 2007-01-15 Compuestos derivados de hidantoina como inhibidores de la enzima de conversion del factor alfa de necrosis tumoral (tace)

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US (2) US7504424B2 (es)
EP (1) EP1976849B1 (es)
JP (1) JP2009523795A (es)
KR (1) KR20080093048A (es)
CN (1) CN101410388A (es)
AR (1) AR058901A1 (es)
AU (1) AU2007207671A1 (es)
BR (1) BRPI0707152A2 (es)
CA (1) CA2637385A1 (es)
EC (1) ECSP088627A (es)
IL (1) IL192692A0 (es)
NO (1) NO20083561L (es)
PE (1) PE20070852A1 (es)
RU (1) RU2008133388A (es)
TW (1) TW200736248A (es)
WO (1) WO2007084415A2 (es)
ZA (1) ZA200806074B (es)

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US7504424B2 (en) * 2004-07-16 2009-03-17 Schering Corporation Compounds for the treatment of inflammatory disorders
AR050169A1 (es) 2004-07-16 2006-10-04 Schering Corp Compuesto para el tratamiento de trastornos inflamatorios
EP1948638B1 (en) * 2005-08-12 2011-08-03 Schering Corporation Compounds for the treatment of inflammatory disorders
AR059036A1 (es) * 2006-01-17 2008-03-12 Schering Corp Compuestos para el tratamiento de trastornos inflamatorios
CA2661605A1 (en) 2006-08-31 2008-03-06 Schering Corporation Hydantoin derivatives useful as antibacterial agents
TW201024303A (en) 2008-09-24 2010-07-01 Schering Corp Compounds for the treatment of inflammatory disorders
AR073307A1 (es) 2008-09-24 2010-10-28 Schering Corp Compuestos para el tratamiento de trastornos inflamatorios
WO2010054278A2 (en) * 2008-11-10 2010-05-14 Schering Corporation Compounds for the treatment of inflammatory disorders
EP2356111A1 (en) 2008-11-10 2011-08-17 Schering Corporation Compounds for the treatment of inflammatory disorders
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CA2817691C (en) * 2010-11-13 2020-09-01 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
JP6083818B2 (ja) 2011-11-18 2017-02-22 ヘプタレス セラピューティクス リミテッドＨｅｐｔａｒｅｓ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ ムスカリンｍ１受容体アゴニスト
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CA2859024C (en) * 2011-12-12 2016-11-08 Allergan, Inc. Benzisothiazol-3(1h)-one-5-sulfonyl derivatives as chemokine receptor modulators
CN105164124B (zh) 2012-11-19 2017-03-15 诺华股份有限公司 用于治疗寄生虫疾病的化合物和组合物
US8871754B2 (en) 2012-11-19 2014-10-28 Irm Llc Compounds and compositions for the treatment of parasitic diseases
ES2694299T3 (es) 2013-02-07 2018-12-19 Heptares Therapeutics Limited Carboxilatos de piperidin-1-ilo y azepin-1-ilo como agonistas del receptor muscarínico M4
KR102321814B1 (ko) 2013-06-07 2021-11-05 가껭세이야꾸가부시기가이샤 (＋)-5-(3,4-디플루오로페닐)-5-[(3-메틸-2-옥소피리딘-1(2h)-일)메틸]이미다졸리딘-2,4-디온 및 그것을 함유하는 의약
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