PE20070120A1 - Derivados de prostaglandina - Google Patents
Derivados de prostaglandinaInfo
- Publication number
- PE20070120A1 PE20070120A1 PE2006000747A PE2006000747A PE20070120A1 PE 20070120 A1 PE20070120 A1 PE 20070120A1 PE 2006000747 A PE2006000747 A PE 2006000747A PE 2006000747 A PE2006000747 A PE 2006000747A PE 20070120 A1 PE20070120 A1 PE 20070120A1
- Authority
- PE
- Peru
- Prior art keywords
- prostaglandin
- cyclopentil
- nitrooxy
- dihydroxy
- hydroxy
- Prior art date
Links
- 150000003180 prostaglandins Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 3- (NITROOXY) PROPYL Chemical class 0.000 abstract 2
- 206010018307 Glaucoma and ocular hypertension Diseases 0.000 abstract 1
- 229910004679 ONO2 Inorganic materials 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- ALBYIUDWACNRRB-UHFFFAOYSA-N hexanamide Chemical compound CCCCCC(N)=O ALBYIUDWACNRRB-UHFFFAOYSA-N 0.000 abstract 1
- CBCIHIVRDWLAME-UHFFFAOYSA-N hexanitrodiphenylamine Chemical class [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1NC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O CBCIHIVRDWLAME-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA R-X-(B)m-Y-ONO2 DONDE R ES EL RESIDUO DE PROSTAGLANDINA DE FORMULA (II) DONDE --- ES UN ENLACE SENCILLO O UN DOBLE ENLACE; L ES BENCILO, HEXILO, ENTRE OTROS; X ES NR1, DONDE R1 ES H O ALQUILO(C1-C6); m ES 0 O 1; B ES CH-(R1')COO, DONDE R1' ES H O ALQUILO(C1-C10) OPCIONALMENTE SUSTITUIDO CON OH, COOH, CONH2, ENTRE OTROS; Y ES ALQUILENO(C1-C20) OPCIONALMENTE SUSTITUIDO CON HALOGENO, OH, ENTRE OTROS, CICLOALQUILENO(C5-C7), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-METIL-N-(3-(NITROOXI)PROPIL) AMIDA DEL ACIDO [1R-[1A(Z),2B(R*),3A,5B]]-7-[3,5-DIHIDROXI-2-(3-HIDROXI-5-FENILPENTIL)CICLOPENTIL]-5-HEPTENOICO; 6-(NITROOXI)HEXIL AMIDA DEL ACIDO [1R-[1A(Z),2B(R*),3A,5A]]-7-[3,5-DIHIDROXI-2-(3-HIDROXI-5-FENILPENTIL)CICLOPENTIL]-5-HEPTENOICO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE GLAUCOMA E HIPERTENSION OCULAR
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69638305P | 2005-06-29 | 2005-06-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20070120A1 true PE20070120A1 (es) | 2007-02-09 |
Family
ID=37309319
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006000747A PE20070120A1 (es) | 2005-06-29 | 2006-06-27 | Derivados de prostaglandina |
Country Status (11)
Country | Link |
---|---|
US (1) | US7718656B2 (es) |
EP (1) | EP1899295A2 (es) |
JP (1) | JP2009501150A (es) |
AR (1) | AR057414A1 (es) |
CA (1) | CA2613748A1 (es) |
GT (1) | GT200600277A (es) |
NL (1) | NL1032046C2 (es) |
PE (1) | PE20070120A1 (es) |
TW (1) | TW200730179A (es) |
UY (1) | UY29627A1 (es) |
WO (1) | WO2007000641A2 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2604562T3 (es) | 2007-02-05 | 2017-03-07 | Nicox Science Ireland | Compuestos donantes de óxido nítrico |
US7960379B2 (en) | 2008-03-14 | 2011-06-14 | Allergan, Inc. | Therapeutic compounds |
AR076731A1 (es) * | 2008-05-09 | 2011-07-06 | Pfizer | Prostamidas donadoras de oxido nitrico, uso de los mismos y composiciones farmaceuticas |
WO2013126156A1 (en) * | 2012-02-22 | 2013-08-29 | Bausch & Lomb Incorporated | Nitric oxide donating selective glucocorticoid receptor agonist compounds and ophthalmic compositions |
EP2826491A1 (en) | 2013-07-15 | 2015-01-21 | Nicox Science Ireland | Ophthalmic compositions containing a nitric oxide donor |
CA2964364A1 (en) * | 2014-10-15 | 2016-04-21 | Novartis Ag | Prostaglandin conjugates and derivatives for treating glaucoma and ocular hypertension |
US10047047B2 (en) | 2015-03-31 | 2018-08-14 | Nicox S.A. | Nitric oxide donating derivatives of latanoprost free acid |
WO2016155906A1 (en) * | 2015-03-31 | 2016-10-06 | Nicox S.A. | Nitric oxide donating derivatives of fluprostenol |
EP3088388A1 (en) | 2015-04-30 | 2016-11-02 | NicOx S.A. | Nitric oxide donating derivatives of prostaglandins |
BR112019009330A2 (pt) | 2016-11-08 | 2019-07-30 | Bausch & Lomb | composto |
KR102069205B1 (ko) * | 2017-08-09 | 2020-01-22 | 연성정밀화학(주) | 라타노프로스틴 부노드의 제조 방법 및 그를 위한 중간체 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3922293A (en) | 1971-12-30 | 1975-11-25 | Upjohn Co | Prostaglandin F-type 9-monoacylates |
US4952581A (en) | 1987-04-03 | 1990-08-28 | The Trustees Of Columbia University In The City Of New York | Use of a prostaglandin in combination with an adrenergic blocking agent for reduction of intraocular pressure |
WO1990002553A1 (en) * | 1988-09-06 | 1990-03-22 | Pharmacia Ab | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
WO1994008585A1 (en) | 1992-10-13 | 1994-04-28 | Alcon Laboratories, Inc. | Combinations of prostaglandins and clonidine derivatives for the treatment of glaucoma |
US5625083A (en) * | 1995-06-02 | 1997-04-29 | Bezuglov; Vladimir V. | Dinitroglycerol esters of unsaturated fatty acids and prostaglandins |
IT1295694B1 (it) | 1996-11-14 | 1999-05-27 | Nicox Sa | Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica |
IT1292377B1 (it) | 1997-06-19 | 1999-02-08 | Nicox Sa | Composizioni farmaceutiche a base di prostaglandine |
US6417228B1 (en) | 1998-11-02 | 2002-07-09 | Alcon Manufacturing, Ltd.. | 13-Aza prostaglandins for the treatment of glaucoma and ocular hypertension |
US7186744B2 (en) | 2003-11-13 | 2007-03-06 | Allergan, Inc. | Prostamides for the treatment of glaucoma and related diseases |
EP1704141B1 (en) * | 2004-01-05 | 2016-02-24 | Nicox S.A. | Prostaglandin nitrooxyderivatives |
-
2006
- 2006-06-19 CA CA002613748A patent/CA2613748A1/en not_active Abandoned
- 2006-06-19 WO PCT/IB2006/001727 patent/WO2007000641A2/en not_active Application Discontinuation
- 2006-06-19 EP EP06765590A patent/EP1899295A2/en not_active Withdrawn
- 2006-06-19 JP JP2008518996A patent/JP2009501150A/ja not_active Withdrawn
- 2006-06-22 NL NL1032046A patent/NL1032046C2/nl not_active IP Right Cessation
- 2006-06-27 PE PE2006000747A patent/PE20070120A1/es not_active Application Discontinuation
- 2006-06-27 UY UY29627A patent/UY29627A1/es not_active Application Discontinuation
- 2006-06-28 TW TW095123347A patent/TW200730179A/zh unknown
- 2006-06-28 AR ARP060102785A patent/AR057414A1/es unknown
- 2006-06-28 GT GT200600277A patent/GT200600277A/es unknown
- 2006-06-28 US US11/478,129 patent/US7718656B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7718656B2 (en) | 2010-05-18 |
TW200730179A (en) | 2007-08-16 |
EP1899295A2 (en) | 2008-03-19 |
US20090062296A1 (en) | 2009-03-05 |
WO2007000641A3 (en) | 2007-03-22 |
NL1032046A1 (nl) | 2007-01-02 |
WO2007000641A2 (en) | 2007-01-04 |
NL1032046C2 (nl) | 2007-04-24 |
UY29627A1 (es) | 2007-01-31 |
JP2009501150A (ja) | 2009-01-15 |
CA2613748A1 (en) | 2007-01-04 |
GT200600277A (es) | 2007-02-14 |
AR057414A1 (es) | 2007-12-05 |
WO2007000641A8 (en) | 2008-03-06 |
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