TW200730179A - Prostaglandin derivatives - Google Patents

Prostaglandin derivatives

Info

Publication number
TW200730179A
TW200730179A TW095123347A TW95123347A TW200730179A TW 200730179 A TW200730179 A TW 200730179A TW 095123347 A TW095123347 A TW 095123347A TW 95123347 A TW95123347 A TW 95123347A TW 200730179 A TW200730179 A TW 200730179A
Authority
TW
Taiwan
Prior art keywords
prostaglandin derivatives
prostaglandin
nitroderivatives
glaucoma
employed
Prior art date
Application number
TW095123347A
Other languages
English (en)
Inventor
Francesca Benedini
Valerio Chiroli
Wesley Kwan Mung Chong
Achim Krauss
Michael Ross Niesman
Ennio Ongini
Original Assignee
Pfizer
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer, Nicox Sa filed Critical Pfizer
Publication of TW200730179A publication Critical patent/TW200730179A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW095123347A 2005-06-29 2006-06-28 Prostaglandin derivatives TW200730179A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69638305P 2005-06-29 2005-06-29

Publications (1)

Publication Number Publication Date
TW200730179A true TW200730179A (en) 2007-08-16

Family

ID=37309319

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095123347A TW200730179A (en) 2005-06-29 2006-06-28 Prostaglandin derivatives

Country Status (11)

Country Link
US (1) US7718656B2 (zh)
EP (1) EP1899295A2 (zh)
JP (1) JP2009501150A (zh)
AR (1) AR057414A1 (zh)
CA (1) CA2613748A1 (zh)
GT (1) GT200600277A (zh)
NL (1) NL1032046C2 (zh)
PE (1) PE20070120A1 (zh)
TW (1) TW200730179A (zh)
UY (1) UY29627A1 (zh)
WO (1) WO2007000641A2 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2677387C (en) * 2007-02-05 2016-06-21 Nicox S.A. Nitric oxide donor compounds
US7960379B2 (en) 2008-03-14 2011-06-14 Allergan, Inc. Therapeutic compounds
AR076731A1 (es) * 2008-05-09 2011-07-06 Pfizer Prostamidas donadoras de oxido nitrico, uso de los mismos y composiciones farmaceuticas
WO2013126156A1 (en) * 2012-02-22 2013-08-29 Bausch & Lomb Incorporated Nitric oxide donating selective glucocorticoid receptor agonist compounds and ophthalmic compositions
EP2826491A1 (en) * 2013-07-15 2015-01-21 Nicox Science Ireland Ophthalmic compositions containing a nitric oxide donor
US9604949B2 (en) * 2014-10-15 2017-03-28 Novartis Ag Prostaglandin conjugates and derivatives for treating glaucoma and ocular hypertension
WO2016155906A1 (en) * 2015-03-31 2016-10-06 Nicox S.A. Nitric oxide donating derivatives of fluprostenol
WO2016156104A1 (en) 2015-03-31 2016-10-06 Nicox S.A. Nitric oxide donating derivatives of latanoprost free acid
EP3088388A1 (en) 2015-04-30 2016-11-02 NicOx S.A. Nitric oxide donating derivatives of prostaglandins
JP7055802B2 (ja) 2016-11-08 2022-04-18 ボシュ・アンド・ロム・インコーポレイテッド 正常眼圧緑内障を処置するための一酸化窒素放出プロスタグランジン誘導体
KR102069205B1 (ko) * 2017-08-09 2020-01-22 연성정밀화학(주) 라타노프로스틴 부노드의 제조 방법 및 그를 위한 중간체

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3922293A (en) * 1971-12-30 1975-11-25 Upjohn Co Prostaglandin F-type 9-monoacylates
US4952581A (en) * 1987-04-03 1990-08-28 The Trustees Of Columbia University In The City Of New York Use of a prostaglandin in combination with an adrenergic blocking agent for reduction of intraocular pressure
ES2213504T1 (es) * 1988-09-06 2004-09-01 Pfizer Health Ab Derivados de prostaglandina para el tratamiento del glaucoma o hipertension ocular.
CA2146127C (en) * 1992-10-13 2000-06-13 Louis Desantis, Jr. Combinations of prostaglandins and clonidine derivatives for the treatment of glaucoma
US5625083A (en) * 1995-06-02 1997-04-29 Bezuglov; Vladimir V. Dinitroglycerol esters of unsaturated fatty acids and prostaglandins
IT1295694B1 (it) * 1996-11-14 1999-05-27 Nicox Sa Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica
IT1292377B1 (it) * 1997-06-19 1999-02-08 Nicox Sa Composizioni farmaceutiche a base di prostaglandine
US6417228B1 (en) * 1998-11-02 2002-07-09 Alcon Manufacturing, Ltd.. 13-Aza prostaglandins for the treatment of glaucoma and ocular hypertension
US7186744B2 (en) 2003-11-13 2007-03-06 Allergan, Inc. Prostamides for the treatment of glaucoma and related diseases
EP1704141B1 (en) * 2004-01-05 2016-02-24 Nicox S.A. Prostaglandin nitrooxyderivatives

Also Published As

Publication number Publication date
WO2007000641A8 (en) 2008-03-06
GT200600277A (es) 2007-02-14
WO2007000641A2 (en) 2007-01-04
PE20070120A1 (es) 2007-02-09
US7718656B2 (en) 2010-05-18
UY29627A1 (es) 2007-01-31
WO2007000641A3 (en) 2007-03-22
NL1032046A1 (nl) 2007-01-02
JP2009501150A (ja) 2009-01-15
AR057414A1 (es) 2007-12-05
US20090062296A1 (en) 2009-03-05
EP1899295A2 (en) 2008-03-19
CA2613748A1 (en) 2007-01-04
NL1032046C2 (nl) 2007-04-24

Similar Documents

Publication Publication Date Title
MY147181A (en) Prostaglandin derivatives.
TW200730179A (en) Prostaglandin derivatives
ATE502633T1 (de) Cyclosporins zur behandlung und vorbeugung von augenerkrankungen
ZA200707531B (en) N-(N-Sulfonylaminomethyl) cyclopropanecarboxamide derivatives useful for the treatment of pain
MY147949A (en) Hydrogenated benzo[c]thiophene derivatives as immunomodulators
MXPA05013733A (es) 2-aminobenzotiazoles como agonistas inversos del receptor de cb1.
JO2282B1 (en) Oxazole derivatives
ATE384058T1 (de) Thiazolderivate
ATE477805T1 (de) 9a-carbamoyl-y-aminopropyl- und 9a-thiocarbamoyl- y-aminopropyl-azalide mit antimalaria-aktivität
ATE449776T1 (de) Pyrroloä2,3-cüpyridinderivate
GB0419174D0 (en) Compositions and methods for the treatment of glaucoma and ocular hypertension
MXPA05010000A (es) Derivados de p-diaminobenceno substituidos.
PT2056804E (pt) Utilização de derivados de 2,5-di-hidroxibenzeno para o tratamento de doenças oculares
NZ597866A (en) Therapeutic lactams
ITMI20070890A1 (it) Composizioni oftalmiche per il trattamento della ipertensione oculare e del glaucoma
MXPA05009282A (es) Derivados de anilina sustituidos.
WO2007056500A3 (en) Compounds with activity at estrogen receptors
ATE525349T1 (de) Pharmazeutische prostaglandinzusammensetzungen
SG171472A1 (en) Substituted aniline derivatives
MXPA05012758A (es) Derivados de captopril.
WO2008075155A3 (en) Carbonic anhydrase inhibitors derivatives
SV2006001987A (es) Derivados de prostaglandina docket 18366
ZA200807828B (en) Prenyltransferase inhibitors for ocular hypertension control and the treatment of glaucoma
MY150436A (en) 1-oxo-isoindoline-4-carboxamide and 1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide derivatives, preparation and therapeutic use thereof
TH99615A (th) อนุพันธ์พรอสทาแกลนดิน