PE20060967A1 - COMPUESTOS DE IMIDAZO[1,2-a]PIRIDINA CON AFINIDAD SOBRE EL RECEPTOR GABA A - Google Patents
COMPUESTOS DE IMIDAZO[1,2-a]PIRIDINA CON AFINIDAD SOBRE EL RECEPTOR GABA AInfo
- Publication number
- PE20060967A1 PE20060967A1 PE2005001302A PE2005001302A PE20060967A1 PE 20060967 A1 PE20060967 A1 PE 20060967A1 PE 2005001302 A PE2005001302 A PE 2005001302A PE 2005001302 A PE2005001302 A PE 2005001302A PE 20060967 A1 PE20060967 A1 PE 20060967A1
- Authority
- PE
- Peru
- Prior art keywords
- imidazo
- alkyl
- pyridin
- tolyl
- cycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A COMPUESTOS DE IMIDAZOL[1,2-a]PIRIDINA DE FORMULA I DONDE R1 Y R2 SON H, ALQUILO C1-C6, ALQUENILO C2-C6, ALQUINIL C2-C6, HALOALQUIL C1-C6, -O-ALQUILO C1-C6, F, Cl, Br; R3 ES H, ALQUILO C1-C6 LINEAL O RAMIFICADO, CICLOALQUILO C3-C6, CICLOALQUIL(C3-C6)ALQUILO(C1-C6), ALQUINIL (C2-C6), ENTRE OTROS; R4 ES H, HALOALQUILO C2-C6, CICLOALQUILO C3-C6, CICLOALQUILO C3-C6-ALQUILO C1-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS (6-METIL-2-p-TOLIL-IMIDAZO[1,2-a]PIRIDIN-3-ILMETIL)-AMIDA DEL ACIDO FURAN-2-CARBOXILICO, (6-METIL-2-p-TOLIL-IMIDAZO[1,2-a]PIRIDIN-3-ILMETIL)-AMIDA DEL ACIDO PIRIDINA-2-CARBOXILICO, (6-METIL-2-p-TOLIL-IMIDAZO[1,2-a]PIRIDIN-3-ILMETIL)-AMIDA DEL ACIDO TIOFENO--2-CARBOXILICO, (6-METIL-2-p-TOLIL-IMIDAZO[1,2-a]PIRIDIN-3-ILMETIL)-AMIDA DEL ACIDO CICLOPROPANOCARBOXILICO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCESO PARA LA PREPARACION Y UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS DESCRITOS TIENEN AFINIDAD SOBRE EL RECEPTOR GABA A Y SON UTILES EN EL TRATAMIENTO DE ANSIEDAD, EPILEPSIA, TRASTORNOS DEL SUENO
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04105698 | 2004-11-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20060967A1 true PE20060967A1 (es) | 2006-09-20 |
Family
ID=34929843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005001302A PE20060967A1 (es) | 2004-11-11 | 2005-11-07 | COMPUESTOS DE IMIDAZO[1,2-a]PIRIDINA CON AFINIDAD SOBRE EL RECEPTOR GABA A |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20080200473A1 (es) |
| EP (1) | EP1814880B1 (es) |
| JP (1) | JP2008519805A (es) |
| KR (1) | KR20070084026A (es) |
| CN (1) | CN101065377B (es) |
| AR (1) | AR051626A1 (es) |
| AT (1) | ATE421962T1 (es) |
| AU (1) | AU2005303811A1 (es) |
| BR (1) | BRPI0517796A (es) |
| CA (1) | CA2585315A1 (es) |
| DE (1) | DE602005012598D1 (es) |
| DK (1) | DK1814880T3 (es) |
| ES (1) | ES2321858T3 (es) |
| IL (1) | IL182963A0 (es) |
| MX (1) | MX2007005611A (es) |
| NO (1) | NO20072831L (es) |
| PA (1) | PA8652101A1 (es) |
| PE (1) | PE20060967A1 (es) |
| PL (1) | PL1814880T3 (es) |
| PT (1) | PT1814880E (es) |
| RU (1) | RU2007121864A (es) |
| TW (1) | TWI357412B (es) |
| UY (1) | UY29204A1 (es) |
| WO (1) | WO2006051063A1 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003220222A1 (en) | 2002-03-13 | 2003-09-29 | Signum Biosciences, Inc. | Modulation of protein methylation and phosphoprotein phosphate |
| US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
| WO2006084033A1 (en) | 2005-02-03 | 2006-08-10 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
| EP1845098A1 (en) * | 2006-03-29 | 2007-10-17 | Ferrer Internacional, S.A. | Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands |
| WO2007137954A1 (en) * | 2006-05-31 | 2007-12-06 | F. Hoffmann-La Roche Ag | Aryl-4-ethynyl-isoxazole derivatives |
| US20100209345A1 (en) * | 2006-08-24 | 2010-08-19 | Australian Nuclear Science & Technology Organisation | Fluorinated Ligands for Targeting Peripheral Benzodiazepine Receptors |
| EP2282735B1 (en) | 2008-04-21 | 2019-01-16 | Signum Biosciences, Inc. | Pp2a modulators for treating alzheimer, parkinson, diabetes |
| JP5774982B2 (ja) | 2008-05-19 | 2015-09-09 | サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | イミダゾ［１，２−ａ］ピリジン化合物 |
| WO2010045615A2 (en) | 2008-10-16 | 2010-04-22 | Cenomed Biosciences, Llc | Treatment of organophosphate exposure with ocinaplon |
| US20120010188A1 (en) * | 2008-12-04 | 2012-01-12 | Promimagen Ltd. | Imidazopyridine Compounds |
| CN106866667B (zh) | 2009-11-05 | 2019-11-15 | 圣母大学 | 咪唑并[1,2-a]吡啶类化合物及其合成及使用方法 |
| TW201225957A (en) * | 2010-09-17 | 2012-07-01 | Taisho Pharmaceutical Co Ltd | Glycine transporter inhibitor |
| CA2998375A1 (en) | 2015-09-17 | 2017-03-23 | Marvin J. Miller | Benzyl amine-containing heterocyclic compounds and compositions useful against mycobacterial infection |
| CN106906486B (zh) * | 2017-02-22 | 2018-12-11 | 华南理工大学 | 3-溴-2-苯基-咪唑并[1,2-α]吡啶类衍生物的电化学合成方法 |
| WO2021155264A1 (en) * | 2020-01-29 | 2021-08-05 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2568880B1 (fr) * | 1984-08-07 | 1986-12-12 | Synthelabo | Derives d'acylaminomethyl-3 imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique |
| FR2593181B1 (fr) * | 1986-01-22 | 1988-04-01 | Synthelabo | Derives d'acylaminomethyl-3 imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique |
| FR2593818B1 (fr) * | 1986-02-05 | 1988-04-29 | Synthelabo | Derives d'acylaminomethyl-3 imidazo(1,2-a)pyridine, leur preparation et leur application en therapeutique |
| EP0234970B1 (fr) * | 1986-01-22 | 1991-04-17 | Synthelabo | Dérivés d'acylaminométhyl-3 imidazo[1,2-a]pyridines, leur préparation et leur application en thérapeutique |
| WO2004066930A2 (en) * | 2003-01-27 | 2004-08-12 | Arthur Zaks | Method for inducing pain relief using imidazo[1,2-a]pyridine derivatives |
-
2005
- 2005-11-04 CA CA002585315A patent/CA2585315A1/en not_active Abandoned
- 2005-11-04 PT PT05808135T patent/PT1814880E/pt unknown
- 2005-11-04 US US11/667,494 patent/US20080200473A1/en not_active Abandoned
- 2005-11-04 DE DE602005012598T patent/DE602005012598D1/de active Active
- 2005-11-04 BR BRPI0517796-0A patent/BRPI0517796A/pt not_active IP Right Cessation
- 2005-11-04 CN CN2005800386913A patent/CN101065377B/zh not_active Expired - Fee Related
- 2005-11-04 AT AT05808135T patent/ATE421962T1/de active
- 2005-11-04 ES ES05808135T patent/ES2321858T3/es active Active
- 2005-11-04 MX MX2007005611A patent/MX2007005611A/es active IP Right Grant
- 2005-11-04 PL PL05808135T patent/PL1814880T3/pl unknown
- 2005-11-04 AU AU2005303811A patent/AU2005303811A1/en not_active Abandoned
- 2005-11-04 JP JP2007540634A patent/JP2008519805A/ja active Pending
- 2005-11-04 EP EP05808135A patent/EP1814880B1/en not_active Not-in-force
- 2005-11-04 KR KR1020077010318A patent/KR20070084026A/ko not_active Application Discontinuation
- 2005-11-04 RU RU2007121864/04A patent/RU2007121864A/ru not_active Application Discontinuation
- 2005-11-04 WO PCT/EP2005/055753 patent/WO2006051063A1/en active Application Filing
- 2005-11-04 DK DK05808135T patent/DK1814880T3/da active
- 2005-11-07 PE PE2005001302A patent/PE20060967A1/es not_active Application Discontinuation
- 2005-11-08 TW TW094139042A patent/TWI357412B/zh not_active IP Right Cessation
- 2005-11-08 PA PA20058652101A patent/PA8652101A1/es unknown
- 2005-11-09 AR ARP050104693A patent/AR051626A1/es not_active Application Discontinuation
- 2005-11-10 UY UY29204A patent/UY29204A1/es not_active Application Discontinuation
-
2007
- 2007-05-03 IL IL182963A patent/IL182963A0/en unknown
- 2007-06-04 NO NO20072831A patent/NO20072831L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20070084026A (ko) | 2007-08-24 |
| MX2007005611A (es) | 2007-07-11 |
| ES2321858T3 (es) | 2009-06-12 |
| DK1814880T3 (da) | 2009-05-18 |
| BRPI0517796A (pt) | 2008-10-28 |
| TW200624432A (en) | 2006-07-16 |
| CN101065377B (zh) | 2011-07-27 |
| UY29204A1 (es) | 2006-01-31 |
| JP2008519805A (ja) | 2008-06-12 |
| DE602005012598D1 (de) | 2009-03-19 |
| EP1814880A1 (en) | 2007-08-08 |
| CN101065377A (zh) | 2007-10-31 |
| PL1814880T3 (pl) | 2009-07-31 |
| PT1814880E (pt) | 2009-04-23 |
| PA8652101A1 (es) | 2006-10-13 |
| TWI357412B (en) | 2012-02-01 |
| US20080200473A1 (en) | 2008-08-21 |
| NO20072831L (no) | 2007-08-01 |
| ATE421962T1 (de) | 2009-02-15 |
| EP1814880B1 (en) | 2009-01-28 |
| AU2005303811A1 (en) | 2006-05-18 |
| WO2006051063A1 (en) | 2006-05-18 |
| CA2585315A1 (en) | 2006-05-18 |
| RU2007121864A (ru) | 2008-12-20 |
| IL182963A0 (en) | 2007-08-19 |
| AR051626A1 (es) | 2007-01-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |