PE20060195A1 - Proceso para la preparacion de una forma de dosificacion solida a prueba de abuso - Google Patents

Proceso para la preparacion de una forma de dosificacion solida a prueba de abuso

Info

Publication number
PE20060195A1
PE20060195A1 PE2005000437A PE2005000437A PE20060195A1 PE 20060195 A1 PE20060195 A1 PE 20060195A1 PE 2005000437 A PE2005000437 A PE 2005000437A PE 2005000437 A PE2005000437 A PE 2005000437A PE 20060195 A1 PE20060195 A1 PE 20060195A1
Authority
PE
Peru
Prior art keywords
abuse
dosage form
solid dosage
preparing
proof solid
Prior art date
Application number
PE2005000437A
Other languages
English (en)
Inventor
Johannes Bartholomaus
Elisabeth Arkenau
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20060195A1 publication Critical patent/PE20060195A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C43/00—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor
    • B29C43/003—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor characterised by the choice of material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C43/00—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor
    • B29C43/006—Pressing and sintering powders, granules or fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2200/00—General characteristics or adaptations
    • A61J2200/20—Extrusion means, e.g. for producing pharmaceutical forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles

Abstract

SE REFIERE A UN PROCESO QUE CONSISTE EN LA EXPOSICION DE UNA MEZCLA, A ULTRASONIDO Y A UNA FUERZA. DICHA MEZCLA CONTIENE: A) PRINCIPIO ACTIVO SUCEPTIBLE DE ABUSO SELECCIONADO ENTRE OPIOIDES, TRANQUILIZANTES, ESTIMULANTES, BARBITURICOS, ENTRE OTROS; B) AGENTE AGLUTINANTE, TAL COMO POLIMERO SINTETICO O NATURAL SELECCIONADO ENTRE POLI(OXIDO DE ETILENO), POLI(OXIDO DE METILENO), POLIPROPILENO, ENTRE OTROS, CON UNA DUREZA IGUAL O MAYOR DE 500 N; C) OPCIONALMENTE UNA CERA NATURAL O SINTETICA CON UN OPUNTO DE ABLANDAMIENTO DE AL MENOS 6O°C. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA DE DOSIFICACION ORAL EN FORMA DE MULTIPLES PARTICULAS, DE PREFERENCIA MICROCOMPRIMIDOS, MICROPELLETS, GRANULADOS, ENTRE OTROS, QUE OPCIONALMENTE SE COMPACTAN EN COMPRIMIDOS O SE LLENAN EN CAPSULAS.DICHO PROCESO GARANTIZA EL EFECTO TERAPEUTICO DESEADO, IMPIDIENDO CONSIDERABLEMENTE LA PULVERIZACION DE LA FORMA DE DOSIFICACION POR MEDIOS CONVENCIONALES Y CON ELLO UN ABUSO SUBSECUENTE
PE2005000437A 2004-04-22 2005-04-20 Proceso para la preparacion de una forma de dosificacion solida a prueba de abuso PE20060195A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004020220A DE102004020220A1 (de) 2004-04-22 2004-04-22 Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
US10/890,703 US20050236741A1 (en) 2004-04-22 2004-07-14 Process for the production of an abuse-proofed solid dosage form

Publications (1)

Publication Number Publication Date
PE20060195A1 true PE20060195A1 (es) 2006-05-10

Family

ID=35140145

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000437A PE20060195A1 (es) 2004-04-22 2005-04-20 Proceso para la preparacion de una forma de dosificacion solida a prueba de abuso

Country Status (10)

Country Link
US (10) US20050236741A1 (es)
CN (1) CN1980643B (es)
AT (1) ATE517610T1 (es)
DE (1) DE102004020220A1 (es)
ES (1) ES2367907T3 (es)
HK (1) HK1100639A1 (es)
IL (1) IL178787A (es)
PE (1) PE20060195A1 (es)
PT (1) PT1740156E (es)
SI (1) SI1740156T1 (es)

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US20160367484A1 (en) 2016-12-22
PT1740156E (pt) 2011-08-18
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HK1100639A1 (en) 2007-09-28
US20160101022A1 (en) 2016-04-14
ATE517610T1 (de) 2011-08-15
US20140155489A1 (en) 2014-06-05
SI1740156T1 (sl) 2011-09-30
US20080317854A1 (en) 2008-12-25
IL178787A0 (en) 2007-03-08
US20150182465A1 (en) 2015-07-02
ES2367907T3 (es) 2011-11-10
US20050236741A1 (en) 2005-10-27
CN1980643A (zh) 2007-06-13
US20160367501A1 (en) 2016-12-22
DE102004020220A1 (de) 2005-11-10
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US20160058710A1 (en) 2016-03-03
IL178787A (en) 2014-01-30

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