PE20050324A1 - Derivados de anilida substituida como ligandos del receptor de tiroides - Google Patents

Derivados de anilida substituida como ligandos del receptor de tiroides

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Publication number
PE20050324A1
PE20050324A1 PE2004000094A PE2004000094A PE20050324A1 PE 20050324 A1 PE20050324 A1 PE 20050324A1 PE 2004000094 A PE2004000094 A PE 2004000094A PE 2004000094 A PE2004000094 A PE 2004000094A PE 20050324 A1 PE20050324 A1 PE 20050324A1
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PE
Peru
Prior art keywords
alkyl
halogen
hydroxy
methylethyl
phenoxy
Prior art date
Application number
PE2004000094A
Other languages
English (en)
Inventor
William N Washburn
Wei Meng
Denis E Ryono
Thomas Ericsson
Neeraj Garg
Mahmoud Rahimi-Ghadim
Bruce A Ellsworth
Johan Malm
Original Assignee
Karobio Ab
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Karobio Ab, Bristol Myers Squibb Co filed Critical Karobio Ab
Publication of PE20050324A1 publication Critical patent/PE20050324A1/es

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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE ANILIDA SUBSTITUIDA DE FORMULA I EN DONDE, X ES O, Se, S, SULFONILO, ENTRE OTROS; R1 ES H, HALOGENO, CF3, ALQUILO C1-C6; R2 ES HALOGENO, CF3, ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS; R3 ES H, ALQUILO, BENCILO, AROILO o ALCANOILO; R4 ES HALOGENO o ALQUILO; R5 ES H, HALOGENO o ALQUILO; R6 Y R7 SON H, HALOGENO, CIANO, ALQUILO C1-C4 o CICLOALQUILO C3-C6, DONDE AL MENOS UNO DE R6 Y R7 NO ES H; R8 Y R9 SON H, HALOGENO, ALCOXI, HIDROXI, CIANO, ENTRE OTROS; CON TAL QUE NO MAS QUE UNO DE R6, R7, R8 Y R9 ES H; R10 ES H o ALQUILO; R11 ES CO2R14; R12 Y R13 SON H, HALOGENO o ALQUILO; R14 ES H, ALQUILO, CICLOALQUILO, ARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: ACIDO 3-[N-[3,5-DIBROMO-4-[4-HIDROXI-3-(1-METILETIL-5-METIL)-FENOXI]-2-METILFENIL]AMINO]-3-OXOPROPANOICO; ACIDO 3-[N-[2,3,5-TRICLORO-4-[4-HIDROXI-3-(1-METILETIL-5-METIL)-FENOXI]FENIL]AMINO]-3-OXOPROPANOICO; ACIDO 3-[N-[3,5-DICLORO-4-[4-HIDROXI-3-(1-METILETIL-5-METIL)-FENOXI]-2-METILFENIL]AMINO]-3-OXOPROPANOICO; ENTRE OTROS. TAMBIEN SE REFIERE A UNA FORMULACION FARMACEUTICA. ESTOS COMPUESTOS SON LIGANDOS DEL RECEPTOR DE LA HORMONA DE TIROIDES Y SON UTILES PARA PREVENIR, INHIBIR O TRATAR ENFERMEDADES O TRASTORNOS ASOCIADOS CON LA DISFUNCION METABOLICA, O LOS CUALES DEPENDEN DE LA EXPRESION DE UN GEN REGULADO POR (3,5,3'-TRIYODO-L-TIRONINA (T3)
PE2004000094A 2003-01-24 2004-01-26 Derivados de anilida substituida como ligandos del receptor de tiroides PE20050324A1 (es)

Applications Claiming Priority (1)

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US44242103P 2003-01-24 2003-01-24

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PE20050324A1 true PE20050324A1 (es) 2005-05-12

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ID=32825218

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PE2004000094A PE20050324A1 (es) 2003-01-24 2004-01-26 Derivados de anilida substituida como ligandos del receptor de tiroides

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US (1) US7342127B2 (es)
EP (1) EP1601641A4 (es)
JP (1) JP2006516623A (es)
AR (1) AR042909A1 (es)
CL (1) CL2004000102A1 (es)
PE (1) PE20050324A1 (es)
TW (1) TW200504021A (es)
WO (1) WO2004067482A2 (es)

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