PE20040998A1 - Nuevas pirazolopirimidinas como inhibidores de cinasas dependientes de ciclinas - Google Patents

Nuevas pirazolopirimidinas como inhibidores de cinasas dependientes de ciclinas

Info

Publication number
PE20040998A1
PE20040998A1 PE2003000898A PE2003000898A PE20040998A1 PE 20040998 A1 PE20040998 A1 PE 20040998A1 PE 2003000898 A PE2003000898 A PE 2003000898A PE 2003000898 A PE2003000898 A PE 2003000898A PE 20040998 A1 PE20040998 A1 PE 20040998A1
Authority
PE
Peru
Prior art keywords
alkyl
inhibitors
cycline
dependent kinases
nr6r7
Prior art date
Application number
PE2003000898A
Other languages
English (en)
Spanish (es)
Inventor
Ronald J Doll
Viyyoor M Girijavallabhan
Kamil Paruch
Chad Knutson
Ray Anthony James
Lawrence W Dillard
Michael P Dwyer
Vinh D Tran
Haengsoon Park
Zhen Min He
Brian Mckittrick
Timothy J Guzi
Original Assignee
Schering Corp
Pharmacopeia Drug Discovery
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp, Pharmacopeia Drug Discovery filed Critical Schering Corp
Publication of PE20040998A1 publication Critical patent/PE20040998A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Pulmonology (AREA)
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  • Dermatology (AREA)
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  • Psychiatry (AREA)
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PE2003000898A 2002-09-04 2003-09-04 Nuevas pirazolopirimidinas como inhibidores de cinasas dependientes de ciclinas PE20040998A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40818202P 2002-09-04 2002-09-04

Publications (1)

Publication Number Publication Date
PE20040998A1 true PE20040998A1 (es) 2004-12-30

Family

ID=31978574

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000898A PE20040998A1 (es) 2002-09-04 2003-09-04 Nuevas pirazolopirimidinas como inhibidores de cinasas dependientes de ciclinas

Country Status (14)

Country Link
US (2) US7084271B2 (https=)
EP (1) EP1545533A1 (https=)
JP (2) JP2006500391A (https=)
KR (1) KR20050057072A (https=)
CN (1) CN1694705A (https=)
AR (1) AR041135A1 (https=)
AU (1) AU2003265901B2 (https=)
CA (1) CA2497539A1 (https=)
MX (1) MXPA05002574A (https=)
NZ (1) NZ539163A (https=)
PE (1) PE20040998A1 (https=)
TW (1) TW200412966A (https=)
WO (1) WO2004022062A1 (https=)
ZA (1) ZA200501854B (https=)

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US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
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US20080125404A1 (en) * 2004-08-27 2008-05-29 Cyclacel Limited Purine and Pyrimidine Cdk Inhitbitors and Their use for The Treatment of Autoimmune Diseases
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CN101103033B (zh) 2005-01-05 2010-08-04 尼科梅德有限责任公司 作为pde2抑制剂的三唑并酞嗪
CA2591991C (en) 2005-01-05 2013-11-19 Altana Pharma Ag Triazolophthalazines
WO2007005541A2 (en) * 2005-06-30 2007-01-11 Philadelphia Health & Education Corporation, D/B/A Drexel University College Of Medicine Small molecule inhibitors against west nile virus replication
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US10953012B2 (en) 2011-04-26 2021-03-23 Bioenergenix Llc Heterocyclic compounds for the inhibition of pask
WO2014066743A1 (en) 2012-10-25 2014-05-01 Bioenergenix Heterocyclic compounds for the inhibition of pask
US10392389B2 (en) 2012-10-25 2019-08-27 Bioenergenix Llc Heterocyclic compounds for the inhibition of PASK
KR20150130491A (ko) 2013-03-13 2015-11-23 제넨테크, 인크. 피라졸로 화합물 및 그것의 용도
SG11201607895PA (en) * 2014-05-28 2016-12-29 Novartis Ag Novel pyrazolo pyrimidine derivatives and their use as malt1 inhibitors
MX2018006250A (es) 2015-11-18 2018-09-05 Genzyme Corp Biomarcador de enfermedad poliquistica renal y usos del mismo.
SI3658557T1 (sl) 2017-07-28 2024-10-30 Takeda Pharmaceutical Company Limited Zaviralci TYK2 in njihova uporaba
CN113248500B (zh) * 2021-06-10 2021-10-19 中国药科大学 氮杂吲哚嘧啶胺杂环化合物及其制备方法和应用

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WO2004022062A1 (en) 2004-03-18
AU2003265901A1 (en) 2004-03-29
ZA200501854B (en) 2005-09-12
AR041135A1 (es) 2005-05-04
US7468372B2 (en) 2008-12-23
MXPA05002574A (es) 2005-09-08
US20060173017A1 (en) 2006-08-03
NZ539163A (en) 2007-03-30
EP1545533A1 (en) 2005-06-29
US20040102452A1 (en) 2004-05-27
JP2006500391A (ja) 2006-01-05
CN1694705A (zh) 2005-11-09
US7084271B2 (en) 2006-08-01
JP2011074088A (ja) 2011-04-14
CA2497539A1 (en) 2004-03-18
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