KR20050057072A - 사이클린 의존성 키나제 억제제로서의 피라졸로피리미딘 - Google Patents

Info

Publication number

KR20050057072A

KR20050057072A KR1020057003548A KR20057003548A KR20050057072A KR 20050057072 A KR20050057072 A KR 20050057072A KR 1020057003548 A KR1020057003548 A KR 1020057003548A KR 20057003548 A KR20057003548 A KR 20057003548A KR 20050057072 A KR20050057072 A KR 20050057072A

Authority

KR

South Korea

Prior art keywords

aryl

compound

alkyl

group

heteroaryl

Prior art date

2002-09-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

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• 229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 title description 7
• 239000002875 cyclin dependent kinase inhibitor Substances 0.000 title description 4
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• 230000002401 inhibitory effect Effects 0.000 claims abstract description 7
• 125000000217 alkyl group Chemical group 0.000 claims description 93
• 125000003118 aryl group Chemical group 0.000 claims description 74
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• 125000000753 cycloalkyl group Chemical group 0.000 claims description 52
• 125000001072 heteroaryl group Chemical group 0.000 claims description 46
• 150000003839 salts Chemical class 0.000 claims description 38
• 229910052736 halogen Inorganic materials 0.000 claims description 32
• 125000000623 heterocyclic group Chemical group 0.000 claims description 29
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 28
• 150000002367 halogens Chemical class 0.000 claims description 25
• 239000012453 solvate Substances 0.000 claims description 24
• UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims description 22
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• 125000005038 alkynylalkyl group Chemical group 0.000 claims description 6
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• 125000003545 alkoxy group Chemical group 0.000 claims description 5
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 5
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 5
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• 125000005842 heteroatom Chemical group 0.000 claims description 5
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• 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims description 4
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• 150000001412 amines Chemical class 0.000 claims description 4
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• DHMTURDWPRKSOA-RUZDIDTESA-N lonafarnib Chemical class C1CN(C(=O)N)CCC1CC(=O)N1CCC([C@@H]2C3=C(Br)C=C(Cl)C=C3CCC3=CC(Br)=CN=C32)CC1 DHMTURDWPRKSOA-RUZDIDTESA-N 0.000 claims description 4
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