PE20040946A1 - Compuestos de pirazolotriazina como ligandos del receptor cannabinoide - Google Patents
Compuestos de pirazolotriazina como ligandos del receptor cannabinoideInfo
- Publication number
- PE20040946A1 PE20040946A1 PE2004000124A PE2004000124A PE20040946A1 PE 20040946 A1 PE20040946 A1 PE 20040946A1 PE 2004000124 A PE2004000124 A PE 2004000124A PE 2004000124 A PE2004000124 A PE 2004000124A PE 20040946 A1 PE20040946 A1 PE 20040946A1
- Authority
- PE
- Peru
- Prior art keywords
- link
- cannabinoid receptor
- bridge
- methylpyrazole
- triazin
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Abstract
SE REFIERE A DERIVADOS DE PIRAZOLOTRIAZINA DE FORMULA I, INCLUYENDO SUS SALES, SOLVATOS E HIDRATOS FARMACEUTICAMENTE ACEPTABLES, DONDE R1 Y R2 SON ARILO O HETEROARILO OPCIONALMENTE SUSTITUIDOS; R3 ES H, ALCOXI C1-C4, ALQUILO C1-C4 OPCIONALMENTE SUSTITUIDO CON HALO; R4 ES UN GRUPO DE FORMULA IA, IB, ENTRE OTROS; EN DONDE R4a ES H o ALQUILO C1-C3; R4b Y R4b` SON H, CN, HIDROXI, AMINO, ENTRE OTROS; o R4b Y R4b` JUNTO CON R4f O R4f` FORMAN UN ENLACE, PUENTE METILENO O PUENTE ETILENO; X ES UN ENLACE CH2-CH2 o C(R4c)(R4c`); R4c Y R4c` SON H, CN, HIDROXI, AMINO, ENTRE OTROS; o R4c Y R4c` JUNTO CON R4f O R4f` FORMAN UN ENLACE, PUENTE METILENO O PUENTE ETILENO; Y ES O, S, ENTRE OTROS; Z ES UN ENLACE, CH2-CH2, ENTRE OTROS; CON LA CONDICION DE QUE R4 NO ES n-BUTILAMINA O DIETILAMINA CUANDO R1 SEA FENILO. SON CUMPUESTOS PREFERIDOS: AMIDA DEL ACIDO 1-[7-(2-CLOROFENIL)-8-(2,4-DICLOROFENIL)-2-METILPIRAZOLO[1,5-a][1,3,5]TRIAZIN-4-IL]-3-ETILAMINOAZETIDIN-3-CARBOXILICO; AMIDA DEL ACIDO 1-[7,8-BIS-(2-CLOROFENIL)-2-METILPIRAZOLO[1,5-a][1,3,5]TRIAZIN-4-IL]-3-ETILAMINOAZETIDIN-3-CARBOXILICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS ACTUAN COMO LIGANDOS DEL RECEPTOR DE CANNABINOIDES, EN PARTICULAR ANTAGONISTAS DEL RECEPTOR CB1
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44572803P | 2003-02-06 | 2003-02-06 |
Publications (1)
Publication Number | Publication Date |
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PE20040946A1 true PE20040946A1 (es) | 2005-01-01 |
Family
ID=32851000
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2004000124A PE20040946A1 (es) | 2003-02-06 | 2004-02-03 | Compuestos de pirazolotriazina como ligandos del receptor cannabinoide |
Country Status (29)
Country | Link |
---|---|
US (1) | US7329658B2 (es) |
EP (1) | EP1592691A1 (es) |
JP (1) | JP4018736B2 (es) |
KR (1) | KR20050099531A (es) |
CN (1) | CN1768061A (es) |
AP (1) | AP2005003368A0 (es) |
AR (1) | AR043038A1 (es) |
AU (1) | AU2004209447A1 (es) |
BR (1) | BRPI0406957A (es) |
CA (1) | CA2513409A1 (es) |
CL (1) | CL2004000182A1 (es) |
CR (1) | CR7932A (es) |
EA (1) | EA200501253A1 (es) |
EC (1) | ECSP055945A (es) |
GT (1) | GT200400013A (es) |
HR (1) | HRP20050659A2 (es) |
IS (1) | IS7936A (es) |
MA (1) | MA27652A1 (es) |
MX (1) | MXPA05007562A (es) |
NL (1) | NL1025404C2 (es) |
NO (1) | NO20054082L (es) |
OA (1) | OA12980A (es) |
PE (1) | PE20040946A1 (es) |
PL (1) | PL379009A1 (es) |
TN (1) | TNSN05190A1 (es) |
TW (1) | TWI260223B (es) |
UY (1) | UY28178A1 (es) |
WO (1) | WO2004069837A1 (es) |
ZA (1) | ZA200506255B (es) |
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BRPI0410289A (pt) * | 2003-05-07 | 2006-05-16 | Pfizer Prod Inc | ligantes do receptor de canabinóides e suas utilizações |
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TWI419889B (zh) * | 2006-07-05 | 2013-12-21 | Mitsubishi Tanabe Pharma Corp | 吡唑并〔1,5-a〕嘧啶化合物 |
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KR100808241B1 (ko) * | 2006-11-21 | 2008-03-03 | 윤성화 | Cb1에 길항 활성을 갖는 1h-파이라졸-3-옥심카바메이트화합물 유도체 |
JP5498168B2 (ja) | 2006-12-01 | 2014-05-21 | ブリストル−マイヤーズ スクイブ カンパニー | アテローム性動脈硬化および循環器疾患の治療のためのcetp阻害剤としてのn−((3−ベンジル)−2,2−(ビス−フェニル)−プロパン−1−アミン誘導体 |
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WO2014078802A1 (en) | 2012-11-19 | 2014-05-22 | Irm Llc | Compounds and compositions for the treatment of parasitic diseases |
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JP2021512959A (ja) * | 2018-02-06 | 2021-05-20 | 江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司Jiangsu Hengrui Medicine Co., Ltd. | ピラゾロ[1,5−a][1,3,5]トリアジン−2−アミン誘導体、その製造法、およびその医薬用途 |
CN110551133A (zh) * | 2019-07-23 | 2019-12-10 | 上海合全药业股份有限公司 | 叔丁基-5-(羟甲基)-7-氧杂-2-氮杂螺[3.5]壬烷-2-甲酸基酯的制法 |
CN112574214B (zh) * | 2019-07-30 | 2021-09-28 | 杭州阿诺生物医药科技有限公司 | 腺苷受体拮抗剂的制备方法 |
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- 2004-01-26 WO PCT/IB2004/000269 patent/WO2004069837A1/en active Application Filing
- 2004-01-26 CN CNA2004800091255A patent/CN1768061A/zh active Pending
- 2004-01-26 EP EP04705138A patent/EP1592691A1/en not_active Withdrawn
- 2004-01-26 JP JP2006500314A patent/JP4018736B2/ja not_active Expired - Fee Related
- 2004-01-26 EA EA200501253A patent/EA200501253A1/ru unknown
- 2004-01-26 CA CA002513409A patent/CA2513409A1/en not_active Abandoned
- 2004-01-26 AP AP2005003368A patent/AP2005003368A0/xx unknown
- 2004-01-26 KR KR1020057014432A patent/KR20050099531A/ko active IP Right Grant
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- 2004-01-26 AU AU2004209447A patent/AU2004209447A1/en not_active Abandoned
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