PE20050421A1 - COMPUESTOS DE PIRAZOLO[4,3-d]PIRIMIDINA Y PIRAZOLO[3,4-d]PIRIDINA COMO LIGANDOS DE RECEPTORES DE CANNABINOIDES - Google Patents

COMPUESTOS DE PIRAZOLO[4,3-d]PIRIMIDINA Y PIRAZOLO[3,4-d]PIRIDINA COMO LIGANDOS DE RECEPTORES DE CANNABINOIDES

Info

Publication number
PE20050421A1
PE20050421A1 PE2004000395A PE2004000395A PE20050421A1 PE 20050421 A1 PE20050421 A1 PE 20050421A1 PE 2004000395 A PE2004000395 A PE 2004000395A PE 2004000395 A PE2004000395 A PE 2004000395A PE 20050421 A1 PE20050421 A1 PE 20050421A1
Authority
PE
Peru
Prior art keywords
pyrazole
chlorophenyl
pyrimidine
pyrazolo
alkyl
Prior art date
Application number
PE2004000395A
Other languages
English (en)
Inventor
David Andrew Griffith
Marlys Hammond
Philip Albert Carpino
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20050421A1 publication Critical patent/PE20050421A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A COMPUESTOS DE PIRAZOLO[4,3-d]PIRIMIDINA Y PIRAZOLO[3,4-d]PIRIDINA DE FORMULA (I), DONDE A ES N O C(R2); R2 ES H, ALQUILO(C1-C4) OPCIONALMENTE SUSTITUIDO CON HALOGENO O ALCOXI(C1-C4); R0 Y R1 SON INDEPENDIENTEMENTE, ARILO O HETEROARILO OPCIONALMENTE SUSTITUIDOS; R3 ES H, ALQUILO(C1-C4) SUSTITUIDO O NO CON HALO O ALCOXI(C1-C4); R4 UN GRUPO DE LA FORMULA IA O IB, -O-C(R5R6R7) DONDE R4a ES H O ALQUILO(C1-C3); R4b y R4b' SON INDEPENDIENTEMENTE, H, CIANO, HIDROXI, AMINO, ENTRE OTROS, O TOMADOS CONJUNTAMENTE CON R4e, R4e', R4f, R4f' FORMAN UN ENLACE O PUENTE METILENO O ETILENO; X ES UN ENLACE, CH2-CH2 O -C(R4C)(R4C'); Y ES O, S, C(O), ENTRE OTROS; Z ES UN ENLACE, CH2CH2, ENTRE OTROS, R4f Y R4f´ SON, INDEPENDIENTEMENTE ENTRE SI, H, CIANO, HIDROXI, AMINO, H2NC(O), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: ACIDO 1-[3-(4-CLOROFENIL)-2-(2,4-DICLOROFENIL)-2H-PIRAZOLO[3,4-c]PIRIDIN-7-IL]-4-ETILAMINOPIPERIDIN-4-CARBOXILICO, 2-[3-(4-CLOROFENIL)-2-(2-CLOROFENIL)-2H-PIRAZOLO[4,3-d]PIRIMIDIN-7-IL]-5-METIL-2,5,7-TRIAZAESPIRO[3,4]OCTAN-8-ONA, 7-(1-BENZOHIDRILAZETIDIN-3-ILOXI)-3-(4-CLOROFENIL)-2-(2-CLOROFENIL)-2H-PIRAZOLO[4,3-d]PIRIMIDINA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON LIGANDOS DE LOS RECEPTORES DE CANNABINOIDES, EN PARTICULAR ANTAGONISTAS DEL RECEPTOR CB1
PE2004000395A 2003-04-23 2004-04-21 COMPUESTOS DE PIRAZOLO[4,3-d]PIRIMIDINA Y PIRAZOLO[3,4-d]PIRIDINA COMO LIGANDOS DE RECEPTORES DE CANNABINOIDES PE20050421A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46491803P 2003-04-23 2003-04-23
US54004804P 2004-01-29 2004-01-29

Publications (1)

Publication Number Publication Date
PE20050421A1 true PE20050421A1 (es) 2005-06-18

Family

ID=33423542

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2004000395A PE20050421A1 (es) 2003-04-23 2004-04-21 COMPUESTOS DE PIRAZOLO[4,3-d]PIRIMIDINA Y PIRAZOLO[3,4-d]PIRIDINA COMO LIGANDOS DE RECEPTORES DE CANNABINOIDES

Country Status (14)

Country Link
US (2) US7268133B2 (es)
EP (1) EP1622904A1 (es)
JP (1) JP3893141B2 (es)
AR (1) AR044539A1 (es)
BR (1) BRPI0409634A (es)
CA (1) CA2520842A1 (es)
CL (1) CL2004000830A1 (es)
MX (1) MXPA05010164A (es)
NL (1) NL1026030C2 (es)
PA (1) PA8601301A1 (es)
PE (1) PE20050421A1 (es)
TW (1) TW200503723A (es)
UY (1) UY28275A1 (es)
WO (1) WO2004096801A1 (es)

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CA2520842A1 (en) 2004-11-11
WO2004096801A1 (en) 2004-11-11
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US7268133B2 (en) 2007-09-11
NL1026030A1 (nl) 2004-11-01
US20040214837A1 (en) 2004-10-28
MXPA05010164A (es) 2005-11-16
US20070275964A1 (en) 2007-11-29
BRPI0409634A (pt) 2006-04-25
CL2004000830A1 (es) 2005-03-18
JP2006524226A (ja) 2006-10-26
UY28275A1 (es) 2004-11-30
AR044539A1 (es) 2005-09-21

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