PE20040705A1 - Polipeptido t20 pegilado - Google Patents

Polipeptido t20 pegilado

Info

Publication number
PE20040705A1
PE20040705A1 PE2003000729A PE2003000729A PE20040705A1 PE 20040705 A1 PE20040705 A1 PE 20040705A1 PE 2003000729 A PE2003000729 A PE 2003000729A PE 2003000729 A PE2003000729 A PE 2003000729A PE 20040705 A1 PE20040705 A1 PE 20040705A1
Authority
PE
Peru
Prior art keywords
sticked
polypeptide
refers
pharmackinetic
nht20
Prior art date
Application number
PE2003000729A
Other languages
English (en)
Inventor
Chee-Youb Won
Pascal Sebastian Bailon
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20040705A1 publication Critical patent/PE20040705A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
    • C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
    • C07K14/16—HIV-1 ; HIV-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DE POLIPEPTIDOS T20 PEGILADOS DE FORMULA I DONDE R1 ES UN GRUPO DE CABEZA; m ES 1-17; n ES 1-1000; p ES 1-3; NHT20 ES UN POLIPEPTIDO T20 UNIDO COVALENTEMENTE A TRAVES DE UN GRUPO a-AMINO TERMINAL. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE INCLUYE DICHOS POLIPEPTIDOS T20 PEGILADOS QUE POSEEN CARACTERISTICAS FARMACOCINETICAS MEJORADAS EN EL TRATAMIENTO DEL VIH
PE2003000729A 2002-07-24 2003-07-22 Polipeptido t20 pegilado PE20040705A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39819502P 2002-07-24 2002-07-24

Publications (1)

Publication Number Publication Date
PE20040705A1 true PE20040705A1 (es) 2004-10-14

Family

ID=31495720

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000729A PE20040705A1 (es) 2002-07-24 2003-07-22 Polipeptido t20 pegilado

Country Status (24)

Country Link
US (1) US7049415B2 (es)
EP (1) EP1527088B1 (es)
JP (1) JP4381301B2 (es)
KR (1) KR100637981B1 (es)
CN (1) CN100357317C (es)
AR (1) AR040651A1 (es)
AT (1) ATE489401T1 (es)
AU (1) AU2003257467B2 (es)
BR (1) BR0312889A (es)
CA (1) CA2493534C (es)
DE (1) DE60335111D1 (es)
ES (1) ES2354609T3 (es)
GT (1) GT200300155A (es)
HR (1) HRP20050024A2 (es)
IL (2) IL166038A0 (es)
MX (1) MXPA05000797A (es)
NO (1) NO20050066L (es)
PA (1) PA8577701A1 (es)
PE (1) PE20040705A1 (es)
PL (1) PL375254A1 (es)
RU (1) RU2296769C2 (es)
TW (1) TW200416225A (es)
WO (1) WO2004013164A1 (es)
ZA (1) ZA200500258B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
ATE477020T1 (de) 2002-06-07 2010-08-15 Dyax Corp Prevention und verringerung von ischemia
CA2536873C (en) * 2003-08-29 2019-09-10 Dyax Corp. Poly-pegylated protease inhibitors
WO2005021556A2 (en) * 2003-08-29 2005-03-10 Dyax Corp. Modified protease inhibitors
WO2005089805A2 (en) * 2004-03-15 2005-09-29 Nektar Therapeutics Al, Corporation Polymer-based compositions and conjugates of hiv entry inhibitors
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
ATE448240T1 (de) * 2005-04-08 2009-11-15 Lonza Ag Peptidsynthese von alpha-helices auf peg-harz
WO2009026334A2 (en) * 2007-08-21 2009-02-26 Genzyme Corporation Treatment with kallikrein inhibitors
AU2010203712A1 (en) 2009-01-06 2010-07-15 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
JP6037841B2 (ja) 2010-01-06 2016-12-07 ダイアックス コーポレーション 血漿カリクレイン結合タンパク質
AU2012204202A1 (en) 2011-01-06 2013-07-11 Dyax Corp. Plasma kallikrein binding proteins
US10428158B2 (en) 2014-03-27 2019-10-01 Dyax Corp. Compositions and methods for treatment of diabetic macular edema
US10046058B2 (en) 2014-12-02 2018-08-14 Rezolute, Inc. Use of hydrophobic organic acids to increase hydrophobicity of proteins and protein conjugates
CN108602893A (zh) 2015-12-11 2018-09-28 戴埃克斯有限公司 血浆激肽释放酶抑制剂及其治疗遗传性血管性水肿发作的用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US153694A (en) * 1874-08-04 Improvement in clothes-pounders
KR850004274A (ko) * 1983-12-13 1985-07-11 원본미기재 에리트로포이에틴의 제조방법
US5252714A (en) * 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
US5464933A (en) * 1993-06-07 1995-11-07 Duke University Synthetic peptide inhibitors of HIV transmission
US5795569A (en) * 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
CH690143A5 (de) * 1995-01-27 2000-05-15 Rieter Automotive Int Ag Lambda/4-Schallabsorber.
US5672662A (en) * 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
US5990237A (en) * 1997-05-21 1999-11-23 Shearwater Polymers, Inc. Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
US6281331B1 (en) * 1998-03-23 2001-08-28 Trimeris, Inc. Methods and compositions for peptide synthesis
JP4602547B2 (ja) * 1998-03-23 2010-12-22 トリメリス，インコーポレーテッド ペプチド合成のための方法および組成物
JP2002531089A (ja) * 1998-11-30 2002-09-24 イーライ・リリー・アンド・カンパニー 赤血球産生性化合物
JO2291B1 (en) * 1999-07-02 2005-09-12 اف . هوفمان لاروش ايه جي Erythropoietin derivatives
KR100488351B1 (ko) * 2001-12-11 2005-05-11 선바이오(주) 신규한 폴리에틸렌글리콜-프로피온알데히드 유도체

Also Published As

Publication number Publication date
PL375254A1 (en) 2005-11-28
TW200416225A (en) 2004-09-01
CA2493534A1 (en) 2004-02-12
GT200300155A (es) 2004-03-15
JP2006511455A (ja) 2006-04-06
CN100357317C (zh) 2007-12-26
JP4381301B2 (ja) 2009-12-09
US7049415B2 (en) 2006-05-23
EP1527088B1 (en) 2010-11-24
HRP20050024A2 (en) 2006-02-28
AU2003257467A1 (en) 2004-02-23
RU2296769C2 (ru) 2007-04-10
KR20050027257A (ko) 2005-03-18
KR100637981B1 (ko) 2006-10-23
BR0312889A (pt) 2005-06-14
MXPA05000797A (es) 2005-04-19
CN1671736A (zh) 2005-09-21
US20040049018A1 (en) 2004-03-11
WO2004013164A1 (en) 2004-02-12
NO20050066L (no) 2005-04-22
ZA200500258B (en) 2006-01-25
CA2493534C (en) 2010-01-26
ES2354609T3 (es) 2011-03-16
DE60335111D1 (de) 2011-01-05
AU2003257467B2 (en) 2008-02-28
PA8577701A1 (es) 2004-02-07
IL166038A0 (en) 2006-01-15
RU2005105577A (ru) 2005-10-27
AR040651A1 (es) 2005-04-13
IL166038A (en) 2010-11-30
EP1527088A1 (en) 2005-05-04
ATE489401T1 (de) 2010-12-15

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