PE20030618A1 - Derivados de c-ciclohexilmetilamina sustituidos, procedimiento para su preparacion, medicamentos que contienen estos compuestos y el uso de derivados de c-ciclohexilmetilamina sustituidos para la preparacion de medicamentos - Google Patents

Derivados de c-ciclohexilmetilamina sustituidos, procedimiento para su preparacion, medicamentos que contienen estos compuestos y el uso de derivados de c-ciclohexilmetilamina sustituidos para la preparacion de medicamentos

Info

Publication number
PE20030618A1
PE20030618A1 PE2001000972A PE2001000972A PE20030618A1 PE 20030618 A1 PE20030618 A1 PE 20030618A1 PE 2001000972 A PE2001000972 A PE 2001000972A PE 2001000972 A PE2001000972 A PE 2001000972A PE 20030618 A1 PE20030618 A1 PE 20030618A1
Authority
PE
Peru
Prior art keywords
derivatives
cyclohexylmetilamine
substitute
preparation
compounds
Prior art date
Application number
PE2001000972A
Other languages
English (en)
Inventor
Bernd Sundermann
Corinna Maul
Helmut Buschmann
Michael Finkam
Babette-Yvonne Kogel
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20030618A1 publication Critical patent/PE20030618A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/52—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/24—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/41—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/79—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/14—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/54—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)

Abstract

SE REFIERE A DERIVADOS DE C-CICLOHEXILMETILAMINA SUSTITUIDOS DE FORMULA I DONDE, A ES H, ARILO O HETEROARILO; R1 ES ALQUILO C1-C1O, CICLOALQUILO C3-C10, ARILO O HETEROARILO LIGADO; R2 Y R3 SON H, ALQUILO C1-C10 , CICLOALQUILO C3-C10, ARILO O HETEROARILO NO SUSTITUIDOS O SUSTITUIDOS; X ES UN ATOMO DE C SUSTITUIDO CON OH, H, F Cl, ENTRE OTROS; Z E Y PUEDEN SER ATOMOS DE C ENLAZADOS CON SIMPLE O DOBLE ENLACE. SON COMPUESTOS PREFERIDOS 4-BENCILOXI-1-(4-BROMOFENIL)-2-DIMETILAMINOMETIL-CICLOHEXANOL, 4-BENCILOXI-2-DIMETILAMINOMETIL-1-(4-TRIFLUOROMETILFENIL)-CICLOHEXANOL, 4-BENCILOXI-1-(3,4-DIFLOUROFENIL)-2-DIMETILAMINOMETIL-CICLOHEXANOL, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS TIENEN EFECTO ANALGESICO UTIL PARA EL TRATAMIENTO DE DOLORES CRONICOS Y NEUROPATICOS
PE2001000972A 2000-09-29 2001-09-28 Derivados de c-ciclohexilmetilamina sustituidos, procedimiento para su preparacion, medicamentos que contienen estos compuestos y el uso de derivados de c-ciclohexilmetilamina sustituidos para la preparacion de medicamentos PE20030618A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10049481A DE10049481A1 (de) 2000-09-29 2000-09-29 Substituierte C-Cyclohexylmethylamin-Derivate

Publications (1)

Publication Number Publication Date
PE20030618A1 true PE20030618A1 (es) 2003-09-27

Family

ID=7658870

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000972A PE20030618A1 (es) 2000-09-29 2001-09-28 Derivados de c-ciclohexilmetilamina sustituidos, procedimiento para su preparacion, medicamentos que contienen estos compuestos y el uso de derivados de c-ciclohexilmetilamina sustituidos para la preparacion de medicamentos

Country Status (30)

Country Link
US (1) US7273952B2 (es)
EP (2) EP1368299B1 (es)
JP (1) JP2004524274A (es)
KR (1) KR100893672B1 (es)
CN (1) CN1547570A (es)
AR (1) AR035062A1 (es)
AT (2) ATE414056T1 (es)
AU (2) AU2002213978B2 (es)
BR (1) BR0114379A (es)
CA (1) CA2423935A1 (es)
CY (2) CY1105247T1 (es)
CZ (1) CZ2003906A3 (es)
DE (3) DE10049481A1 (es)
DK (2) DK1571140T3 (es)
EC (1) ECSP034531A (es)
ES (2) ES2317103T3 (es)
HK (2) HK1080071A1 (es)
HU (1) HUP0303184A3 (es)
IL (1) IL155103A0 (es)
MX (1) MXPA03002348A (es)
NO (1) NO20031386L (es)
NZ (2) NZ545879A (es)
PE (1) PE20030618A1 (es)
PL (1) PL366057A1 (es)
PT (2) PT1571140E (es)
RU (1) RU2295515C2 (es)
SI (2) SI1571140T1 (es)
SK (1) SK3412003A3 (es)
WO (1) WO2002030870A2 (es)
ZA (1) ZA200303224B (es)

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DE10153347A1 (de) * 2001-10-29 2003-05-08 Gruenenthal Gmbh Substituierte 1H-Chinolin-2-on-Verbindungen
DE10153346A1 (de) 2001-10-29 2004-04-22 Grünenthal GmbH Substituierte Indole
DE10161644A1 (de) * 2001-12-14 2003-06-26 Gruenenthal Gmbh N,N'-disubstituierte Piperazin-Verbindungen
DE10261091A1 (de) * 2002-12-20 2004-07-01 Grünenthal GmbH Gesättigte und ungesättigte Heteroarylcycloalkylmethyl-Amine
DE102004039382A1 (de) * 2004-08-13 2006-02-23 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102005061428A1 (de) * 2005-12-22 2007-08-16 Grünenthal GmbH Substituierte Cyclohexylmethyl-Derivate
TWI496762B (zh) 2006-07-24 2015-08-21 製備（１ｒ，２ｒ）-３-（３-二甲胺基-１-乙基-２-甲基-丙基）-酚之方法
RU2470011C2 (ru) * 2007-05-31 2012-12-20 Сепракор Инк. Циклоалкиламины, содержащие в качестве заместителя фенил, как ингибиторы обратного захвата моноаминов
CN101906056B (zh) * 2009-06-04 2013-10-30 中国科学院广州生物医药与健康研究院 作为m2抑制剂的环烷胺类化合物及其应用
WO2012100423A1 (en) 2011-01-27 2012-08-02 Eli Lilly And Company Analgesic compounds, methods, and formulations
CN105837454B (zh) * 2016-04-21 2018-06-08 河南师范大学 一种3,3-二氟环己基甲胺的合成方法
CN112759545B (zh) * 2019-11-06 2022-12-13 复旦大学 3-(二甲氨基甲基)哌啶-4-醇类衍生物及其制备方法和药物用途
CN112759546B (zh) * 2019-11-06 2022-08-26 复旦大学 3-(二甲氨基甲基)哌啶-4-醇衍生物及其制备方法和药物用途
CN112759544B (zh) * 2019-11-06 2022-08-26 复旦大学 3-(二甲氨基甲基)哌啶-4-醇衍生物制备方法和药物用途
US20230027752A1 (en) * 2019-11-06 2023-01-26 Fudan University Opioid receptor agonist, preparation method therefor and pharmaceutical use thereof
CN112759587B (zh) * 2019-11-06 2022-12-30 复旦大学 3-(二甲氨基甲基)哌啶-4-醇类衍生物及其制备方法和药物用途
CN112759538B (zh) * 2019-11-06 2022-01-18 复旦大学 3-(二甲氨基甲基)环己-4-醇衍生物及其制备方法和药物用途

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Also Published As

Publication number Publication date
DK1571140T3 (da) 2009-03-09
PL366057A1 (en) 2005-01-24
AU2002213978B2 (en) 2007-10-18
JP2004524274A (ja) 2004-08-12
EP1368299A2 (de) 2003-12-10
IL155103A0 (en) 2003-10-31
SI1368299T1 (sl) 2006-12-31
ATE414056T1 (de) 2008-11-15
WO2002030870A3 (de) 2003-10-02
HK1080071A1 (en) 2006-04-21
DE10049481A1 (de) 2002-05-02
ES2317103T3 (es) 2009-04-16
WO2002030870A2 (de) 2002-04-18
KR20030059165A (ko) 2003-07-07
DK1368299T3 (da) 2006-11-27
EP1368299B1 (de) 2006-07-26
DE50110569D1 (en) 2006-09-07
ES2267833T3 (es) 2007-03-16
SI1571140T1 (sl) 2009-04-30
CA2423935A1 (en) 2003-03-27
CY1110258T1 (el) 2015-01-14
ECSP034531A (es) 2003-05-26
BR0114379A (pt) 2004-12-14
MXPA03002348A (es) 2003-06-30
EP1571140A1 (de) 2005-09-07
CN1547570A (zh) 2004-11-17
PT1368299E (pt) 2006-11-30
EP1571140B1 (de) 2008-11-12
AR035062A1 (es) 2004-04-14
US7273952B2 (en) 2007-09-25
NO20031386L (no) 2003-05-26
KR100893672B1 (ko) 2009-04-20
PT1571140E (pt) 2009-02-16
DE50114491D1 (de) 2008-12-24
RU2295515C2 (ru) 2007-03-20
ATE334114T1 (de) 2006-08-15
HUP0303184A3 (en) 2008-03-28
NZ545879A (en) 2007-08-31
NO20031386D0 (no) 2003-03-26
HUP0303184A2 (hu) 2003-12-29
CY1105247T1 (el) 2010-03-03
HK1061018A1 (en) 2004-09-03
CZ2003906A3 (cs) 2003-06-18
AU1397802A (en) 2002-04-22
NZ525170A (en) 2006-08-31
US20030232891A1 (en) 2003-12-18
ZA200303224B (en) 2004-08-13
SK3412003A3 (en) 2003-08-05

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