PE20030519A1 - Forma de dosificacion, dispositivo y metodos de tratamiento - Google Patents

Forma de dosificacion, dispositivo y metodos de tratamiento

Info

Publication number
PE20030519A1
PE20030519A1 PE2002001028A PE2002001028A PE20030519A1 PE 20030519 A1 PE20030519 A1 PE 20030519A1 PE 2002001028 A PE2002001028 A PE 2002001028A PE 2002001028 A PE2002001028 A PE 2002001028A PE 20030519 A1 PE20030519 A1 PE 20030519A1
Authority
PE
Peru
Prior art keywords
formulation
quantities
rumen
agent
default
Prior art date
Application number
PE2002001028A
Other languages
English (en)
Spanish (es)
Inventor
Joseph Raymond Winkle
Lionel Barry Lowe
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3832213&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20030519(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20030519A1 publication Critical patent/PE20030519A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0068Rumen, e.g. rumen bolus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/04Sulfur, selenium or tellurium; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007Effervescent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/14Ectoparasiticides, e.g. scabicides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Inorganic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PE2002001028A 2001-10-19 2002-10-17 Forma de dosificacion, dispositivo y metodos de tratamiento PE20030519A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AUPR8390A AUPR839001A0 (en) 2001-10-19 2001-10-19 Dosage form, device and methods of treatment

Publications (1)

Publication Number Publication Date
PE20030519A1 true PE20030519A1 (es) 2003-06-13

Family

ID=3832213

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002001028A PE20030519A1 (es) 2001-10-19 2002-10-17 Forma de dosificacion, dispositivo y metodos de tratamiento

Country Status (22)

Country Link
US (1) US20050064032A1 (enExample)
EP (1) EP1448151A4 (enExample)
JP (1) JP2005510485A (enExample)
KR (1) KR20050037410A (enExample)
CN (1) CN1571663A (enExample)
AR (1) AR037116A1 (enExample)
AU (5) AUPR839001A0 (enExample)
BR (1) BR0212975A (enExample)
CA (1) CA2463674A1 (enExample)
CR (1) CR7312A (enExample)
EA (1) EA005778B1 (enExample)
EC (1) ECSP045063A (enExample)
HR (1) HRP20040231A2 (enExample)
HU (1) HUP0401808A3 (enExample)
IL (1) IL160754A0 (enExample)
MX (1) MXPA04003679A (enExample)
NO (1) NO20041941L (enExample)
NZ (1) NZ531672A (enExample)
PE (1) PE20030519A1 (enExample)
PL (1) PL368387A1 (enExample)
WO (1) WO2003033031A1 (enExample)
ZA (1) ZA200403743B (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRN20030021A1 (it) 2003-07-21 2005-01-22 Ascor Chimici Srl Composizione di materia comprendente particelle contenenti cloruro di colina da somministrare in forma ruminalmente protetta e post-ruminalmente efficace.
ITMI20041820A1 (it) * 2004-09-24 2004-12-24 Ascor Chimici Srl Composizione in micro-pellets a rilascio controllato di sostanze fisiologicamente attive, procedimento di preparazione e relativo impiego nel settore zootecnico.
EP1830886B1 (en) * 2004-12-27 2016-04-13 Eisai R&D Management Co., Ltd. Method for stabilizing anti-dementia drug
US20060246003A1 (en) * 2004-12-27 2006-11-02 Eisai Co. Ltd. Composition containing anti-dementia drug
US20060280789A1 (en) * 2004-12-27 2006-12-14 Eisai Research Institute Sustained release formulations
US20090208579A1 (en) * 2004-12-27 2009-08-20 Eisai R & D Management Co., Ltd. Matrix Type Sustained-Release Preparation Containing Basic Drug or Salt Thereof, and Method for Manufacturing the Same
NZ554260A (en) * 2007-09-30 2010-05-28 Agres Ltd Selenomethionine andor selenocysteine administration to non-human animals to increase selenium content in protein sources
WO2010126857A1 (en) * 2009-04-28 2010-11-04 Wyeth Llc Parasiticidal combinations of macrocyclic lactones and polyether antibiotics
AU2014203209B2 (en) * 2009-07-31 2015-11-26 Boehringer Ingelheim Animal Health USA Inc. Sustained release capsules
MX347258B (es) 2009-07-31 2017-04-20 Merial Ltd Capsulas de liberacion sostenida.
CA2784141C (en) * 2009-12-17 2017-10-24 Merial Limited Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles
FR2992219B1 (fr) * 2012-06-22 2014-07-11 Aditec Lab Composition pour le traitement de l'hypocalcemie chez les ruminants
HUE065006T2 (hu) * 2014-07-03 2024-04-28 SpecGx LLC Nem-cellulóz poliszacharidokat tartalmazó, visszaélés-gátló, azonnali felszabadulású készítmények
US11065246B2 (en) 2016-02-08 2021-07-20 SpecGx LLC Glucomannan containing pharmaceutical compositions with extended release and abuse deterrent properties
IL266377B2 (en) * 2016-12-02 2023-10-01 Clexio Biosciences Ltd Gastric residence system
WO2019005700A1 (en) * 2017-06-26 2019-01-03 Merial, Inc. DOUBLE-ACTING PARASITICIDE GRANULATE COMPOSITIONS, METHODS AND USES THEREOF
CA189878S (en) * 2017-08-25 2021-02-18 Argenta Mfg Limited Intraruminal device
US20220054809A1 (en) * 2018-09-10 2022-02-24 Argenta Innovation Limited Controlled release formulations in delivery devices
CA3112317A1 (en) * 2018-09-10 2020-03-19 Argenta Innovation Limited Sustained release formulations in delivery devices
WO2020068510A1 (en) 2018-09-25 2020-04-02 SpecGx LLC Abuse deterrent immediate release capsule dosage forms
JP7376691B2 (ja) * 2019-08-14 2023-11-08 エランコ ティーアゲズンタイト アーゲー ウィング付カプセルのための新しいウィングプロテクタとその使用方法
CA3166002A1 (en) * 2020-02-07 2021-08-12 Elke Wagner Winged capsule
AU2021278871A1 (en) * 2020-05-28 2023-01-19 Boehringer Ingelheim Animal Health USA Inc. Bi-modal release intra-ruminal capsule device and methods of use thereof
DK4037666T3 (da) 2020-12-08 2024-06-24 Ruminant Biotech Corp Ltd Forbedring af anordninger og fremgangsmåder til indgivelse af substanser til dyr
CN113398337A (zh) * 2021-06-23 2021-09-17 上海市肺科医院 包含抗结核药物缓释植入人工骨载体的脊柱内固定装置
CN118743817B (zh) * 2024-09-04 2025-01-21 中国农业大学 一种瘤胃持续给药系统
CN119454625A (zh) * 2024-10-29 2025-02-18 山东鲁西兽药股份有限公司 一种反刍动物用驱虫中药提取物微量元素维生素缓释丸

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU520409B2 (en) * 1977-05-25 1982-01-28 Commonwealth Scientific And Industrial Research Organisation Controlled release composition
GB2077586A (en) * 1980-06-12 1981-12-23 Standard Telephones Cables Ltd Sustained-release device
NZ197543A (en) * 1980-07-02 1984-12-14 Commw Scient Ind Res Org Controlled release compositions for inclusion in intraruminal devices
US4416659A (en) * 1981-11-09 1983-11-22 Eli Lilly And Company Sustained release capsule for ruminants
NZ203203A (en) * 1982-02-16 1985-09-13 Commw Scient Ind Res Org Controlled release device:gas diffusion limited
IE54171B1 (en) * 1982-06-22 1989-07-05 Univ Glasgow Device for introducing nutrients and/or therapeutic materials into ruminant animals
GB8328916D0 (en) * 1983-10-28 1983-11-30 Castex Prod Pharmaceutical pellet
US4777049A (en) * 1983-12-01 1988-10-11 Alza Corporation Constant release system with pulsed release
NZ212100A (en) * 1984-06-02 1988-07-28 Castex Prod Rumen bolus; outer casing sheds in segments
US4723958A (en) * 1986-05-23 1988-02-09 Merck & Co., Inc. Pulsatile drug delivery system
US4867980A (en) * 1986-10-10 1989-09-19 Coopers Animal Health Australia Limited Heavy density depot
US5391381A (en) * 1987-06-25 1995-02-21 Alza Corporation Dispenser capable of delivering plurality of drug units
US4874388A (en) * 1987-06-25 1989-10-17 Alza Corporation Multi-layer delivery system
US5938654A (en) * 1987-06-25 1999-08-17 Alza Corporation Osmotic device for delayed delivery of agent
US5110597A (en) * 1987-06-25 1992-05-05 Alza Corporation Multi-unit delivery system
US4957494A (en) * 1987-06-25 1990-09-18 Alza Corporation Multi-layer delivery system
US5023088A (en) * 1987-06-25 1991-06-11 Alza Corporation Multi-unit delivery system
US4915949A (en) * 1987-07-13 1990-04-10 Alza Corporation Dispenser with movable matrix comprising a plurality of tiny pills
GB8829089D0 (en) * 1988-12-13 1989-01-25 Coopers Animal Health Intra ruminal device
DK0386440T3 (da) * 1989-02-11 1992-09-14 Bayer Ag Lægemidler med kontrolleret afgivelse af virksomt stof
US5110598A (en) * 1989-06-30 1992-05-05 Smithkline Beecham Corp. Intermittent release dosage form
US5126142A (en) * 1989-07-18 1992-06-30 Alza Corporation Dispenser comprising ionophore
US5017381A (en) * 1990-05-02 1991-05-21 Alza Corporation Multi-unit pulsatile delivery system
MX9200339A (es) * 1991-01-28 1992-08-01 Hoechst Ag Preparado para la liberacion controlada de sustancias activas, que son apropiadas como terapeuticos o para mejorar el crecimiento y el aprovechamiento de los piensos en rumiantes
US5417682A (en) * 1991-01-30 1995-05-23 Alza Corporation Device for administering active agent to biological environment
AU650113B2 (en) * 1991-04-05 1994-06-09 Eli Lilly And Company Sustained release capsule and formulations
US5240713A (en) * 1991-09-27 1993-08-31 Alza Corporation Dual rate agent delivery device
US5221278A (en) * 1992-03-12 1993-06-22 Alza Corporation Osmotically driven delivery device with expandable orifice for pulsatile delivery effect
DK0739198T3 (da) * 1994-01-20 2004-01-26 Agres Ltd Anordning til indgivelse af gavnlige materialer til drøvtyggere
AUPM897594A0 (en) * 1994-10-25 1994-11-17 Daratech Pty Ltd Controlled release container
CA2348871C (en) * 1998-11-02 2009-04-14 John G. Devane Multiparticulate modified release composition
US6569857B1 (en) * 1999-05-03 2003-05-27 Drugtech Corporation Dietary supplement
DE19956486A1 (de) * 1999-11-24 2001-06-21 Lohmann Therapie Syst Lts Mehrschichtige Zubereitung zur gesteuerten, pulsartigen Abgabe von Wirkstoffen
US7326425B2 (en) * 1999-12-31 2008-02-05 Rutgers, The State University Pharmaceutical formulation composed of a polymer blend and an active compound for time-controlled release
WO2001064191A1 (de) * 2000-02-28 2001-09-07 Akzo Nobel N.V. Körper für die kontrollierte abgabe von wirkstoffen

Also Published As

Publication number Publication date
EA005778B1 (ru) 2005-06-30
HRP20040231A2 (en) 2004-08-31
NZ531672A (en) 2006-08-31
AUPR839001A0 (en) 2001-11-15
AU2005227413A1 (en) 2005-11-17
AU2002332975C1 (en) 2009-01-29
NO20041941L (no) 2004-05-10
KR20050037410A (ko) 2005-04-21
AU2002332975B2 (en) 2005-02-03
ZA200403743B (en) 2005-05-16
HUP0401808A3 (en) 2005-11-28
AU2004210542A1 (en) 2004-09-30
AU2004210542B2 (en) 2005-07-28
CN1571663A (zh) 2005-01-26
AR037116A1 (es) 2004-10-20
IL160754A0 (en) 2004-08-31
EA200400557A1 (ru) 2005-02-24
AU2004210542C1 (en) 2009-01-08
WO2003033031A1 (en) 2003-04-24
AU2004210542B9 (en) 2005-09-01
BR0212975A (pt) 2004-10-13
CR7312A (es) 2004-10-27
EP1448151A4 (en) 2010-01-13
AU2009250987A1 (en) 2010-01-14
CA2463674A1 (en) 2003-04-24
MXPA04003679A (es) 2004-07-23
EP1448151A1 (en) 2004-08-25
ECSP045063A (es) 2004-05-28
JP2005510485A (ja) 2005-04-21
US20050064032A1 (en) 2005-03-24
HUP0401808A2 (hu) 2005-01-28
PL368387A1 (en) 2005-03-21
AU2002332975B9 (en) 2005-03-17

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