EA005778B1 - Дозированная форма, устройство и способы лечения - Google Patents
Дозированная форма, устройство и способы лечения Download PDFInfo
- Publication number
- EA005778B1 EA005778B1 EA200400557A EA200400557A EA005778B1 EA 005778 B1 EA005778 B1 EA 005778B1 EA 200400557 A EA200400557 A EA 200400557A EA 200400557 A EA200400557 A EA 200400557A EA 005778 B1 EA005778 B1 EA 005778B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- release
- specified
- rumen
- controlled
- active agent
- Prior art date
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Classifications
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- A61K9/0012—Galenical forms characterised by the site of application
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- A61K9/0068—Rumen, e.g. rumen bolus
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
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- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
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- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physiology (AREA)
- Inorganic Chemistry (AREA)
- Nutrition Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPR8390A AUPR839001A0 (en) | 2001-10-19 | 2001-10-19 | Dosage form, device and methods of treatment |
| PCT/AU2002/001426 WO2003033031A1 (en) | 2001-10-19 | 2002-10-18 | Dosage form, device and methods of treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200400557A1 EA200400557A1 (ru) | 2005-02-24 |
| EA005778B1 true EA005778B1 (ru) | 2005-06-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200400557A EA005778B1 (ru) | 2001-10-19 | 2002-10-18 | Дозированная форма, устройство и способы лечения |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20050064032A1 (enExample) |
| EP (1) | EP1448151A4 (enExample) |
| JP (1) | JP2005510485A (enExample) |
| KR (1) | KR20050037410A (enExample) |
| CN (1) | CN1571663A (enExample) |
| AR (1) | AR037116A1 (enExample) |
| AU (5) | AUPR839001A0 (enExample) |
| BR (1) | BR0212975A (enExample) |
| CA (1) | CA2463674A1 (enExample) |
| CR (1) | CR7312A (enExample) |
| EA (1) | EA005778B1 (enExample) |
| EC (1) | ECSP045063A (enExample) |
| HR (1) | HRP20040231A2 (enExample) |
| HU (1) | HUP0401808A3 (enExample) |
| IL (1) | IL160754A0 (enExample) |
| MX (1) | MXPA04003679A (enExample) |
| NO (1) | NO20041941L (enExample) |
| NZ (1) | NZ531672A (enExample) |
| PE (1) | PE20030519A1 (enExample) |
| PL (1) | PL368387A1 (enExample) |
| WO (1) | WO2003033031A1 (enExample) |
| ZA (1) | ZA200403743B (enExample) |
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| ITRN20030021A1 (it) * | 2003-07-21 | 2005-01-22 | Ascor Chimici Srl | Composizione di materia comprendente particelle contenenti cloruro di colina da somministrare in forma ruminalmente protetta e post-ruminalmente efficace. |
| ITMI20041820A1 (it) * | 2004-09-24 | 2004-12-24 | Ascor Chimici Srl | Composizione in micro-pellets a rilascio controllato di sostanze fisiologicamente attive, procedimento di preparazione e relativo impiego nel settore zootecnico. |
| US20090208579A1 (en) * | 2004-12-27 | 2009-08-20 | Eisai R & D Management Co., Ltd. | Matrix Type Sustained-Release Preparation Containing Basic Drug or Salt Thereof, and Method for Manufacturing the Same |
| WO2006070930A1 (en) * | 2004-12-27 | 2006-07-06 | Eisai R & D Management Co., Ltd. | Method for stabilizing anti-dementia drug |
| US20060246003A1 (en) * | 2004-12-27 | 2006-11-02 | Eisai Co. Ltd. | Composition containing anti-dementia drug |
| US20060280789A1 (en) * | 2004-12-27 | 2006-12-14 | Eisai Research Institute | Sustained release formulations |
| NZ554260A (en) * | 2007-09-30 | 2010-05-28 | Agres Ltd | Selenomethionine andor selenocysteine administration to non-human animals to increase selenium content in protein sources |
| WO2010126857A1 (en) * | 2009-04-28 | 2010-11-04 | Wyeth Llc | Parasiticidal combinations of macrocyclic lactones and polyether antibiotics |
| AU2014203209B2 (en) * | 2009-07-31 | 2015-11-26 | Boehringer Ingelheim Animal Health USA Inc. | Sustained release capsules |
| AU2010277872C1 (en) * | 2009-07-31 | 2017-01-19 | Boehringer Ingelheim Animal Health USA Inc. | Sustained release capsules |
| MX2012006921A (es) * | 2009-12-17 | 2012-07-10 | Merial Ltd | Composiciones que comprenden compuestos de lactona macrociclica y espirodioxepinoindoles. |
| FR2992219B1 (fr) * | 2012-06-22 | 2014-07-11 | Aditec Lab | Composition pour le traitement de l'hypocalcemie chez les ruminants |
| EP3164117B1 (en) | 2014-07-03 | 2023-09-06 | SpecGx LLC | Abuse deterrent immediate release formulations comprising non-cellulose polysaccharides |
| JP2019504072A (ja) | 2016-02-08 | 2019-02-14 | スペックジーエックス エルエルシー | 徐放性及び濫用抑止特性を有するグルコマンナン含有医薬組成物 |
| US10737079B2 (en) * | 2016-12-02 | 2020-08-11 | Clexio Biosciences Ltd. | Gastric residence system |
| WO2019005700A1 (en) * | 2017-06-26 | 2019-01-03 | Merial, Inc. | DOUBLE-ACTING PARASITICIDE GRANULATE COMPOSITIONS, METHODS AND USES THEREOF |
| USD909604S1 (en) | 2017-08-25 | 2021-02-02 | Argenta Manufacturing Limited | Barrel of an intraruminal device |
| BR112021004523A2 (pt) * | 2018-09-10 | 2021-06-08 | Argenta Innovation Limited | formulações para liberação sustentada em dispositivos de administração |
| AU2019338076B2 (en) * | 2018-09-10 | 2025-07-31 | Argenta Innovation Limited | Controlled release formulations in delivery devices |
| EP3856160A4 (en) | 2018-09-25 | 2022-07-06 | SpecGx LLC | ANTI-ABUSE IMMEDIATE RELEASE CAPSULES DOSAGE FORMS |
| US11612471B2 (en) * | 2019-08-14 | 2023-03-28 | Elanco Us Inc. | Wing protector for winged capsule and method of using same |
| CN115135279A (zh) * | 2020-02-07 | 2022-09-30 | 礼蓝动物保健公司 | 带翼胶囊 |
| AU2021278871A1 (en) * | 2020-05-28 | 2023-01-19 | Boehringer Ingelheim Animal Health USA Inc. | Bi-modal release intra-ruminal capsule device and methods of use thereof |
| MA59413B1 (fr) | 2020-12-08 | 2024-07-31 | Ruminant Biotech Corp Limited | Améliorations apportées à des dispositifs et des méthodes d'administration de substances aux animaux |
| CN113398337A (zh) * | 2021-06-23 | 2021-09-17 | 上海市肺科医院 | 包含抗结核药物缓释植入人工骨载体的脊柱内固定装置 |
| CN118743817B (zh) * | 2024-09-04 | 2025-01-21 | 中国农业大学 | 一种瘤胃持续给药系统 |
| CN119454625A (zh) * | 2024-10-29 | 2025-02-18 | 山东鲁西兽药股份有限公司 | 一种反刍动物用驱虫中药提取物微量元素维生素缓释丸 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU520409B2 (en) * | 1977-05-25 | 1982-01-28 | Commonwealth Scientific And Industrial Research Organisation | Controlled release composition |
| GB2077586A (en) * | 1980-06-12 | 1981-12-23 | Standard Telephones Cables Ltd | Sustained-release device |
| NZ197543A (en) * | 1980-07-02 | 1984-12-14 | Commw Scient Ind Res Org | Controlled release compositions for inclusion in intraruminal devices |
| US4416659A (en) * | 1981-11-09 | 1983-11-22 | Eli Lilly And Company | Sustained release capsule for ruminants |
| NZ203203A (en) * | 1982-02-16 | 1985-09-13 | Commw Scient Ind Res Org | Controlled release device:gas diffusion limited |
| IE54171B1 (en) * | 1982-06-22 | 1989-07-05 | Univ Glasgow | Device for introducing nutrients and/or therapeutic materials into ruminant animals |
| GB8328916D0 (en) * | 1983-10-28 | 1983-11-30 | Castex Prod | Pharmaceutical pellet |
| US4777049A (en) * | 1983-12-01 | 1988-10-11 | Alza Corporation | Constant release system with pulsed release |
| GR851195B (enExample) * | 1984-06-02 | 1985-11-25 | Castex Prod | |
| US4723958A (en) * | 1986-05-23 | 1988-02-09 | Merck & Co., Inc. | Pulsatile drug delivery system |
| US4867980A (en) * | 1986-10-10 | 1989-09-19 | Coopers Animal Health Australia Limited | Heavy density depot |
| US5110597A (en) * | 1987-06-25 | 1992-05-05 | Alza Corporation | Multi-unit delivery system |
| US5023088A (en) * | 1987-06-25 | 1991-06-11 | Alza Corporation | Multi-unit delivery system |
| US5391381A (en) * | 1987-06-25 | 1995-02-21 | Alza Corporation | Dispenser capable of delivering plurality of drug units |
| US5938654A (en) * | 1987-06-25 | 1999-08-17 | Alza Corporation | Osmotic device for delayed delivery of agent |
| US4874388A (en) * | 1987-06-25 | 1989-10-17 | Alza Corporation | Multi-layer delivery system |
| US4957494A (en) * | 1987-06-25 | 1990-09-18 | Alza Corporation | Multi-layer delivery system |
| US4915949A (en) * | 1987-07-13 | 1990-04-10 | Alza Corporation | Dispenser with movable matrix comprising a plurality of tiny pills |
| GB8829089D0 (en) * | 1988-12-13 | 1989-01-25 | Coopers Animal Health | Intra ruminal device |
| EP0386440B1 (de) * | 1989-02-11 | 1992-08-05 | Bayer Ag | Arzneimittel mit kontrollierter Wirkstoffabgabe |
| US5110598A (en) * | 1989-06-30 | 1992-05-05 | Smithkline Beecham Corp. | Intermittent release dosage form |
| US5126142A (en) * | 1989-07-18 | 1992-06-30 | Alza Corporation | Dispenser comprising ionophore |
| US5017381A (en) * | 1990-05-02 | 1991-05-21 | Alza Corporation | Multi-unit pulsatile delivery system |
| MX9200339A (es) * | 1991-01-28 | 1992-08-01 | Hoechst Ag | Preparado para la liberacion controlada de sustancias activas, que son apropiadas como terapeuticos o para mejorar el crecimiento y el aprovechamiento de los piensos en rumiantes |
| US5417682A (en) * | 1991-01-30 | 1995-05-23 | Alza Corporation | Device for administering active agent to biological environment |
| AU650113B2 (en) * | 1991-04-05 | 1994-06-09 | Eli Lilly And Company | Sustained release capsule and formulations |
| US5240713A (en) * | 1991-09-27 | 1993-08-31 | Alza Corporation | Dual rate agent delivery device |
| US5221278A (en) * | 1992-03-12 | 1993-06-22 | Alza Corporation | Osmotically driven delivery device with expandable orifice for pulsatile delivery effect |
| AU697144B2 (en) * | 1994-01-20 | 1998-10-01 | Agresearch Limited | Device for administration of beneficial materials to ruminants |
| AUPM897594A0 (en) * | 1994-10-25 | 1994-11-17 | Daratech Pty Ltd | Controlled release container |
| KR20070051953A (ko) * | 1998-11-02 | 2007-05-18 | 엘란 코포레이션, 피엘씨 | 다입자 변형 방출 조성물 |
| US6569857B1 (en) * | 1999-05-03 | 2003-05-27 | Drugtech Corporation | Dietary supplement |
| DE19956486A1 (de) * | 1999-11-24 | 2001-06-21 | Lohmann Therapie Syst Lts | Mehrschichtige Zubereitung zur gesteuerten, pulsartigen Abgabe von Wirkstoffen |
| EP1251864A4 (en) * | 1999-12-31 | 2006-02-22 | Univ Rutgers | PHARMACEUTICAL FORMULATION COMPRISING A POLYMERIC MIXTURE AND AN ACTIVE COMPOUND FOR TIME-RELEASED RELEASE |
| WO2001064191A1 (de) * | 2000-02-28 | 2001-09-07 | Akzo Nobel N.V. | Körper für die kontrollierte abgabe von wirkstoffen |
-
2001
- 2001-10-19 AU AUPR8390A patent/AUPR839001A0/en not_active Abandoned
-
2002
- 2002-10-17 PE PE2002001028A patent/PE20030519A1/es not_active Application Discontinuation
- 2002-10-18 AR ARP020103936A patent/AR037116A1/es unknown
- 2002-10-18 BR BR0212975-2A patent/BR0212975A/pt not_active IP Right Cessation
- 2002-10-18 EP EP02801251A patent/EP1448151A4/en not_active Withdrawn
- 2002-10-18 HU HU0401808A patent/HUP0401808A3/hu unknown
- 2002-10-18 PL PL02368387A patent/PL368387A1/xx not_active Application Discontinuation
- 2002-10-18 WO PCT/AU2002/001426 patent/WO2003033031A1/en not_active Ceased
- 2002-10-18 AU AU2002332975A patent/AU2002332975C1/en not_active Expired
- 2002-10-18 CA CA002463674A patent/CA2463674A1/en not_active Abandoned
- 2002-10-18 MX MXPA04003679A patent/MXPA04003679A/es active IP Right Grant
- 2002-10-18 US US10/490,975 patent/US20050064032A1/en not_active Abandoned
- 2002-10-18 KR KR1020047005590A patent/KR20050037410A/ko not_active Ceased
- 2002-10-18 HR HR20040231A patent/HRP20040231A2/hr not_active Application Discontinuation
- 2002-10-18 CN CNA028207009A patent/CN1571663A/zh active Pending
- 2002-10-18 IL IL16075402A patent/IL160754A0/xx unknown
- 2002-10-18 JP JP2003535833A patent/JP2005510485A/ja active Pending
- 2002-10-18 EA EA200400557A patent/EA005778B1/ru not_active IP Right Cessation
- 2002-10-18 NZ NZ531672A patent/NZ531672A/en not_active IP Right Cessation
-
2004
- 2004-04-15 EC EC2004005063A patent/ECSP045063A/es unknown
- 2004-04-16 CR CR7312A patent/CR7312A/es unknown
- 2004-05-10 NO NO20041941A patent/NO20041941L/no not_active Application Discontinuation
- 2004-05-14 ZA ZA200403743A patent/ZA200403743B/en unknown
- 2004-09-09 AU AU2004210542A patent/AU2004210542C1/en not_active Expired
-
2005
- 2005-10-28 AU AU2005227413A patent/AU2005227413A1/en not_active Abandoned
-
2009
- 2009-12-16 AU AU2009250987A patent/AU2009250987A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AUPR839001A0 (en) | 2001-11-15 |
| AR037116A1 (es) | 2004-10-20 |
| CN1571663A (zh) | 2005-01-26 |
| NZ531672A (en) | 2006-08-31 |
| AU2002332975B9 (en) | 2005-03-17 |
| HUP0401808A3 (en) | 2005-11-28 |
| WO2003033031A1 (en) | 2003-04-24 |
| HUP0401808A2 (hu) | 2005-01-28 |
| ZA200403743B (en) | 2005-05-16 |
| CR7312A (es) | 2004-10-27 |
| AU2005227413A1 (en) | 2005-11-17 |
| KR20050037410A (ko) | 2005-04-21 |
| EP1448151A1 (en) | 2004-08-25 |
| AU2004210542A1 (en) | 2004-09-30 |
| IL160754A0 (en) | 2004-08-31 |
| PE20030519A1 (es) | 2003-06-13 |
| MXPA04003679A (es) | 2004-07-23 |
| BR0212975A (pt) | 2004-10-13 |
| EA200400557A1 (ru) | 2005-02-24 |
| NO20041941L (no) | 2004-05-10 |
| ECSP045063A (es) | 2004-05-28 |
| AU2002332975B2 (en) | 2005-02-03 |
| AU2004210542B2 (en) | 2005-07-28 |
| PL368387A1 (en) | 2005-03-21 |
| AU2009250987A1 (en) | 2010-01-14 |
| CA2463674A1 (en) | 2003-04-24 |
| HRP20040231A2 (en) | 2004-08-31 |
| EP1448151A4 (en) | 2010-01-13 |
| AU2004210542B9 (en) | 2005-09-01 |
| US20050064032A1 (en) | 2005-03-24 |
| AU2002332975C1 (en) | 2009-01-29 |
| JP2005510485A (ja) | 2005-04-21 |
| AU2004210542C1 (en) | 2009-01-08 |
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Legal Events
| Date | Code | Title | Description |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |